全文获取类型
收费全文 | 6297篇 |
免费 | 292篇 |
国内免费 | 69篇 |
专业分类
耳鼻咽喉 | 33篇 |
儿科学 | 122篇 |
妇产科学 | 63篇 |
基础医学 | 705篇 |
口腔科学 | 149篇 |
临床医学 | 467篇 |
内科学 | 1570篇 |
皮肤病学 | 226篇 |
神经病学 | 345篇 |
特种医学 | 231篇 |
外科学 | 1108篇 |
综合类 | 25篇 |
预防医学 | 217篇 |
眼科学 | 36篇 |
药学 | 355篇 |
中国医学 | 14篇 |
肿瘤学 | 992篇 |
出版年
2023年 | 76篇 |
2022年 | 148篇 |
2021年 | 249篇 |
2020年 | 121篇 |
2019年 | 192篇 |
2018年 | 205篇 |
2017年 | 142篇 |
2016年 | 186篇 |
2015年 | 181篇 |
2014年 | 201篇 |
2013年 | 233篇 |
2012年 | 355篇 |
2011年 | 393篇 |
2010年 | 252篇 |
2009年 | 158篇 |
2008年 | 284篇 |
2007年 | 326篇 |
2006年 | 278篇 |
2005年 | 281篇 |
2004年 | 270篇 |
2003年 | 248篇 |
2002年 | 234篇 |
2001年 | 153篇 |
2000年 | 143篇 |
1999年 | 161篇 |
1998年 | 67篇 |
1997年 | 64篇 |
1996年 | 48篇 |
1995年 | 42篇 |
1994年 | 40篇 |
1993年 | 29篇 |
1992年 | 83篇 |
1991年 | 66篇 |
1990年 | 73篇 |
1989年 | 68篇 |
1988年 | 64篇 |
1987年 | 59篇 |
1986年 | 59篇 |
1985年 | 59篇 |
1984年 | 52篇 |
1983年 | 34篇 |
1982年 | 18篇 |
1979年 | 26篇 |
1974年 | 14篇 |
1973年 | 16篇 |
1971年 | 26篇 |
1970年 | 24篇 |
1969年 | 16篇 |
1967年 | 19篇 |
1966年 | 20篇 |
排序方式: 共有6658条查询结果,搜索用时 15 毫秒
41.
Hiroyuki Hisada Yoshiki Sakaguchi Kaori Oshio Satoru Mizutani Hideki Nakagawa Junichi Sato Dai Kubota Miho Obata Rina Cho Sayaka Nagao Yuko Miura Hiroya Mizutani Daisuke Ohki Seiichi Yakabi Yu Takahashi Naomi Kakushima Yosuke Tsuji Nobutake Yamamichi Mitsuhiro Fujishiro 《Current oncology (Toronto, Ont.)》2022,29(7):4678
Although the mortality rates of gastric cancer (GC) are gradually declining, gastric cancer is still the fourth leading cause of cancer-related death worldwide. This may be due to the high rate of patients who are diagnosed with GC at advanced stages. However, in countries such as Japan with endoscopic screening systems, more than half of GCs are discovered at an early stage, enabling endoscopic resection (ER). Especially after the introduction of endoscopic submucosal dissection (ESD) in Japan around 2000, a high en bloc resection rate allowing pathological assessment of margin and depth has become possible. While ER is a diagnostic method of treatment and may not always be curative, it is widely accepted as standard treatment because it is less invasive than surgery and can provide an accurate diagnosis for deciding whether additional surgery is necessary. The curability of ER is currently assessed by the completeness of primary tumor removal and the possibility of lymph node metastasis. This review introduces methods, indications, and curability criteria for ER of EGC. Despite recent advances, several problems remain unsolved. This review will also outline the latest evidence concerning future issues. 相似文献
42.
43.
Haruka Uezono Kayoko Tsujino Keno Moriki Fumiko Nagano Yosuke Ota Ryohei Sasaki Toshinori Soejima 《Journal of radiation research》2013,54(6):1102-1109
The purpose of this study is to determine the incidence, clinical characteristics and risk factors of postradiation pelvic insufficiency fracture (PIF) in women with uterine cervical cancer. We reviewed the medical records of 126 patients who received definitive radiotherapy (RT) for uterine cervical cancer between 2003 and 2009 at our institution. Among them, 99 patients who underwent at least one computed tomography (CT) or magnetic resonance imaging of the pelvis during their follow-up at more than 6 months were included in this analysis. The relationship between the incidence of PIF and several patient- and treatment-related factors was analyzed. The median follow-up period was 21 months. Of the 126 patients, 33 (with a total of 50 lesions) were diagnosed with PIF. The 2-year cumulative incidence was 32%. Univariate analysis showed that age ≥70 years (P= 0.0010), postmenopausal state (P = 0.0013), and lower CT density of bone and bone marrow (P= 0.020) significantly related to PIF. In a multivariate analysis, of the 59 patients whose CT densities were evaluable, lower CT density was the only significant factor associated with PIF (P = 0.0026). In conclusion, postradiation PIFs were detected in a considerable number of patients after definitive RT for cervical cancer. Predisposing factors were older age, postmenopausal state, and decreased density of bone and bone marrow on CT. 相似文献
44.
Keisuke Goto Naoya Tajima Etsuo Chosa Koji Totoribe Hiroshi Kuroki Yuichi Arizumi Takashi Arai 《Journal of orthopaedic science》2002,7(2):243-246
We established a three-dimensional finite element method (FEM) model of the 4th and 5th vertebrae, using computed tomography
(CT) images (2-mm slice thickness) of a healthy 29-year-old man. Because of the lack of specific data regarding the material
characteristics of the nucleus pulposus of intervertebral discs, we used intradiscal pressure in the nucleus pulposus to establish
the model. We referred to data from Nachemson and from Sato et al. regarding intradiscal pressure and to the methods of Shirazi-Adl
for data for other material characteristics (see text for these references). The mid-position model bears a load of 294 N
in the vertical direction, while the models of the flexed and extended positions bear loads of 15 N-m. In addition, a degenerative
disc model without intradiscal pressure was created for the standing model. The use of these models allowed the investigation
of von Mises stress on the vertebral endplates and the annulus fibrosus. We also examined von Mises stress on the facet joint
in normal and degenerative disc models. There was increased von Mises stress on the vertebral endplate in the anterior, center
portions. von Mises stress on the annulus fibrosus increased in the posterior portion, the entrance to the neural foramen,
and the exit of the neural foramen. von Mises stress was greater during flexion in the posterior portion; in particular, increasing
to about 1.6 times the level seen with other postures. No changes were observed in von Mises stress on the vertebral endplates
or annulus fibrosus in the degenerative disc model, but von Mises stress on the facet joints was about 2.5 times that seen
in the normal disc model.
Received: June 28, 2001 / Accepted: October 27, 2001 相似文献
45.
46.
Reiko Tajima Masahide Kondo Hirayasu Kai Chie Saito Masafumi Okada Hideto Takahashi Mariko Doi Shuichi Tsuruoka Kunihiro Yamagata 《Clinical and experimental nephrology》2010,14(4):340-348
Background
Chronic kidney disease (CKD) is a health-related quality-of-life (HRQOL) deteriorating disease which is not only a public health but also a socioeconomic problem. Interest in developing cost-effective interventions to control CKD has increased. The aim of this study was to measure HRQOL in terms of quality-adjustment weights for cost-effectiveness analysis using EQ-5D in patients with CKD. The relationships between the measured HRQOL and clinical indices/complications were also analyzed. 相似文献47.
Yosuke Fukunaga Masayuki Higashino Shinnya Tanimura Masashi Takemura Yushi Fujiwara 《Surgical endoscopy》2010,24(1):145-151
Background
The usefulness of laparoscopic low anterior resection for middle and lower rectal cancer remains controversial. 相似文献48.
Etoh T Shiraishi N Tajima M Shiromizu A Yasuda K Inomata M Kitano S 《World journal of surgery》2007,31(5):1116-1121
Introduction The effect of laparoscopic surgery under CO2 pneumoperitoneum on liver function is not clear. The aim of this study was to clarify whether laparoscopy-assisted distal
gastrectomy (LADG) is associated with changes in liver function compared with open distal gastrectomy (ODG).
Methods A total of 205 patients who underwent LADG (n = 147) or ODG (n = 58) between January 1994 and April 2004 were included in
this study. Liver function tests—aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin, total bilirubin—were
examined before surgery and at 1, 3, and 7 days after surgery. The postoperative clinical course was compared between the
two groups.
Results AST levels on day 1 and ALT levels on days 1 and 3 were significantly higher in the LADG group. Albumin levels showed a marked
decrease after operation in both groups, but the level recovered more rapidly in the LADG group than in the ODG group, showing
significant differences on days 3 and 7. The total bilirubin levels remained unchanged from baseline. The postoperative complication
rate was similar in the two groups, although 3 LADG patients among the 27 patients with liver disease suffered severe enteritis.
Conclusions Transient liver dysfunction was documented in patients after laparoscopic gastrectomy under CO2 pneumoperitoneum. 相似文献
49.
Fukui T Shibata T Sasaki Y Hirai H Motoki M Takahashi Y Nakahira A Suehiro S 《General thoracic and cardiovascular surgery》2007,55(10):403-408
Objective Coronary artery bypass grafting (CABG) in patients with left ventricular dysfunction has been considered to be a challenging
operation. We assessed the early angiographic and long-term clinical and functional outcomes of patients with poor left ventricular
function who underwent isolated CABG.
Methods We retrospectively reviewed the records of 78 patients with a poor left ventricular ejection fraction (35% or less) who underwent
isolated CABG between January 1991 and November 2006. The mean age of the patients was 66.1 ± 9.4 years, and their mean New
York Heart Association functional class was 3.1 ± 0.8. Their mean end-diastolic left ventricular diameter was 57.4 ± 8.1 mm,
and their mean grade of mitral regurgitation was 0.7 ± 1.0. Early postoperative angiograms were performed at 32.5 ± 33.5 days
after the operation. Interval echocardiographic data were analyzed, and the long-term survival rate was evaluated.
Results The average number of distal anastomoses per patient was 3.2 ± 1.1. The operative mortality rate was 7.7%. Stroke occurred
in 1.3% of patients. The overall patency rates for arterial and venous grafts were 100% and 97.2%, respectively. The left
ventricular ejection fraction significantly improved from 28.2% ± 5.1% to 34.4% ± 8.4%. Both the end-diastolic and end-systolic
left ventricular dimensions significantly decreased from 57.4 ± 8.1 to 55.1 ± 8.8 mm and from 47.4 ± 8.4 to 45.1 ± 9.7 mm,
respectively. The actuarial patient survival rate at 10 years was 73.1%.
Conclusion CABG in patients with left ventricular dysfunction was effective, with favorable early graft patency rates. The long-term
outcome was also acceptable, with echocardiographic functional recovery. 相似文献
50.
Iwaki R Ozaki N Tanaka Y Wakita N 《Interactive Cardiovascular and Thoracic Surgery》2011,13(4):429-431
Popliteal artery entrapment syndrome is recognized as a cause of lower leg claudication in patients younger than 50 years of age. We report a rare case of a patient with bilateral popliteal artery entrapment who presented with the same symptom 11 years after his first experience of popliteal artery entrapment syndrome. On both occasions, the surgery was performed in a similar manner and the patient was free from symptoms after the surgery. Since the diagnosis of popliteal artery entrapment syndrome is difficult, early detection of popliteal artery entrapment syndrome is important to prevent its progression. 相似文献