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81.
Yoshitaka Maeda Sayaka Yoshida Toshiyuki Hirai Tomoki Kawasaki Tamaki Kuyama 《Journal of Rural Medicine》2013,8(1):171-175
Objective: The usefulness of estimated glomerular filtration rate may not be
restricted to pre-dialysis patients, since we reported that estimated glomerular
filtration rate was well correlated with measured total creatinine clearance in peritoneal
dialysis patients. To clarify the clinical usefulness of estimated glomerular filtration
rate as a parameter for peritoneal dialysis adequacy, we retrospectively surveyed
estimated glomerular filtration rate and total creatinine clearance in peritoneal dialysis
patients treated at JA Toride Medical Center.Patients and Methods: A total of 114 data sets of estimated glomerular
filtration rate and total creatinine clearance from 21 PD patients treated at JA Toride
Medical Center were collected from November 2010 to October 2011. The patients consisted
of 15 men and six women with an average age of 66.6 ± 12.6 years (46–95 years old). The
average number of samples was 5.4 ± 1.5 (2 to 7) per patient.Results: The collected data showed less correlation of estimated glomerular
filtration rate and total creatinine clearance (r. = 0.435) than that of a previous
cross-sectional study (r. = 0.836). As reported in pre-dialysis patients, the differences
between estimated glomerular filtration rate and total creatinine clearance were
correlated with total creatinine excretion in urine and PD effluent (r. = 0.821). The
differences were also correlated with normalized protein catabolic rate, which was one of
the main determinant factors for total creatinine excretion (r. = 0.636). A similar
tendency was apparently observed in one patient with poor compliance to diet therapy and
fluctuating dietary intake. From the analysis of these data, serum creatinine seemed to
fluctuate less possibly due to compensatory capacity of the residual renal function in
small solute clearance.Conclusions: Consequently, estimated glomerular filtration rate was turned
out to be a more stable parameter than total creatinine clearance, which might be a
desirable feature in long-term follow-up of peritoneal dialysis patients. 相似文献
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Sherri Dudal Daniel Baltrukonis Rebecca Crisino M. Jaya Goyal Alison Joyce Karolina Österlund John Smeraglia Yoshitaka Taniguchi Jihong Yang 《The AAPS journal》2014,16(2):194-205
As part of the GBC (Global Bioanalysis Consortium), the L3 assay format team has focused on reviewing common platforms used to support ligand binding assays in the detection of biotherapeutics. The following review is an overview of discussions and presentations from around the globe with a group of experts from different companies to allow an international harmonization of common practices and suggestions for different platforms. Some of the major platforms include Gyrolab, Erenna, RIA, AlphaLISA, Delfia, Immuno-PCR, Luminex, BIAcore, and ELISAs. The review is meant to support bioanalysts in taking decisions between different platforms depending on the needs of the analyte with a number of recommendations to help integration of platforms into a GLP environment. 相似文献
86.
Takashi Uchiyama Hirokazu Takahashi Hiroki Endo Shingo Kato Eiji Sakai Kunihiro Hosono Masato Yoneda Masahiko Inamori Yoshitaka Hippo Hitoshi Nakagama Atsushi Nakajima 《Digestive endoscopy》2012,24(5):353-357
Aim: Endoscopic screening and removal of colorectal adenomas can reduce the incidence of colorectal cancer. However, given the possibility of adenoma recurrence, surveillance colonoscopy is currently recommended after the initial screening and removal of colorectal adenomas. Aberrant crypt foci (ACF) have been shown to serve as a reliable surrogate marker of colorectal carcinogenesis. In this study, the relationship between the number of ACF at the initial endoscopic polypectomy and the likelihood of colorectal adenoma recurrence after polypectomy were investigated. Methods: High‐magnification chromoscopic colonoscopy was performed in 82 subjects who underwent endoscopic polypectomy to identify ACF in the lower rectum. Surveillance colonoscopy was then performed 3 years after the baseline polypectomy at Yokohama City University Hospital. Results: The number of ACF was greater in patients who showed adenoma recurrence (7.88 ± 6.35) than in those who did not (2.19 ± 2.95) (P < 0.001). Receiver–operating curve analysis showed that the number of ACF was a highly specific predictor of the risk of adenoma recurrence. Conclusions: This is the first study conducted to investigate the relationship between the number of ACF after endoscopic polypectomy and the likelihood of recurrence of colorectal adenomas. These results suggest that the number of ACF is a useful predictor of the likelihood of colorectal adenoma recurrence. 相似文献
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Yozo Sato Yoshitaka Inaba Hidekazu Yamaura Haruyuki Takaki Yasuaki Arai 《Journal of vascular and interventional radiology : JVIR》2012,23(10):1377-1380
A 65-year-old woman with liver metastases from colon cancer and tumor thrombus extending from the right hepatic vein (HV) to the right atrium (RA) presented with marked lower-extremity edema and massive ascites. Computed tomography showed tumor thrombus completely occluding the inferior vena cava (IVC) and HV ostia. Recanalization of the IVC and HVs was performed. Metallic stents were placed in tandem from the superior vena cava to the IVC through the RA, and additional metallic stents were placed in the left HV. The patient's symptoms were relieved, and there was no recurrence of these symptoms for 19.5 months until death. 相似文献
90.
Hiyama T Tanaka S Yoshihara M Sasao S Kose K Shima H Tuncel H Ueno Y Ito M Kitadai Y Yasui W Haruma K Chayama K 《Journal of gastroenterology and hepatology》2004,19(7):756-760
BACKGROUND: Gastric cancer can progress through two pathways of genomic instability: chromosomal (CIN) and microsatellite instability (MSI). It is hypothesized that these two pathways are not always independent and that some tumors show overlap between these two mechanisms. METHODS: A total of 98 sporadic gastric cancers were classified based on their MSI status, using microsatellite assay with BAT26. Evidence for CIN was investigated by identifying loss of heterozygosity (LOH) events on chromosome arms, 5q, 10p, 17p, 17q, and 18q, which are regions harboring tumor suppressor genes that are significant in gastric cancer development. RESULTS: Twelve tumors (12%) showed high-frequency MSI (MSI-H). Overall, 43 of the tumors (44%) had at least one LOH event, with most frequent chromosomal losses observed on 10p and 18q (30%, respectively), followed by 5q (21%), 17p (14%), and 17q (12%). Interestingly, overlap was observed between CIN and MSI pathways. Of 43 cancers with LOH events, four (9%) were also MSI-H. It was also found that 48% of cancers without MSI-H had no LOH events identified, comprising a subgroup of tumors that were not representative of either of these two pathways of genomic instability. CONCLUSION: These results suggest that molecular mechanisms of genomic instability are not necessarily independent and may not be fully defined by either the MSI or CIN pathways in sporadic gastric cancers. 相似文献