全文获取类型
收费全文 | 4240篇 |
免费 | 201篇 |
国内免费 | 29篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 112篇 |
妇产科学 | 16篇 |
基础医学 | 476篇 |
口腔科学 | 55篇 |
临床医学 | 310篇 |
内科学 | 1215篇 |
皮肤病学 | 95篇 |
神经病学 | 257篇 |
特种医学 | 110篇 |
外科学 | 784篇 |
综合类 | 7篇 |
预防医学 | 96篇 |
眼科学 | 117篇 |
药学 | 248篇 |
中国医学 | 13篇 |
肿瘤学 | 546篇 |
出版年
2023年 | 15篇 |
2022年 | 32篇 |
2021年 | 60篇 |
2020年 | 39篇 |
2019年 | 67篇 |
2018年 | 95篇 |
2017年 | 67篇 |
2016年 | 87篇 |
2015年 | 100篇 |
2014年 | 121篇 |
2013年 | 166篇 |
2012年 | 260篇 |
2011年 | 286篇 |
2010年 | 174篇 |
2009年 | 139篇 |
2008年 | 276篇 |
2007年 | 313篇 |
2006年 | 294篇 |
2005年 | 327篇 |
2004年 | 321篇 |
2003年 | 265篇 |
2002年 | 269篇 |
2001年 | 45篇 |
2000年 | 46篇 |
1999年 | 60篇 |
1998年 | 79篇 |
1997年 | 50篇 |
1996年 | 52篇 |
1995年 | 35篇 |
1994年 | 44篇 |
1993年 | 44篇 |
1992年 | 23篇 |
1991年 | 21篇 |
1990年 | 21篇 |
1989年 | 30篇 |
1988年 | 21篇 |
1987年 | 10篇 |
1986年 | 7篇 |
1985年 | 12篇 |
1984年 | 16篇 |
1983年 | 9篇 |
1982年 | 12篇 |
1981年 | 10篇 |
1980年 | 11篇 |
1979年 | 7篇 |
1978年 | 5篇 |
1977年 | 4篇 |
1975年 | 3篇 |
1965年 | 2篇 |
1964年 | 2篇 |
排序方式: 共有4470条查询结果,搜索用时 46 毫秒
81.
Kensaku Yamaga Eisuke Kobayashi Daisuke Kubota Nokitaka Setsu Yuya Tanaka Yusuke Minami Yoshikazu Tanzawa Fumihiko Nakatani Akira Kawai Hirokazu Chuman 《Pediatrics international》2015,57(5):996-999
Myositis ossificans (MO) is a rare benign cause of heterotopic bone formation in soft tissue that most commonly affects young adults, typically following trauma. We report the case of an 11‐year‐old girl who developed MO mimicking osteosarcoma in her right shoulder. Plain radiography and computed tomography showed poorly defined flocculated densities in the soft tissue and a periosteal reaction along the proximal humerus. On magnetic resonance imaging, the mass displayed an ill‐defined margin and inhomogeneous signal change. Histologically, the mass had a pseudosarcomatous appearance. Based on these findings, the patient was initially misdiagnosed with osteosarcoma at another hospital. The diagnosis was difficult because the patient was 11 years old and had no trauma history, with atypical radiographic changes and a predilection for the site of origin for osteosarcomas. We finally made the correct diagnosis of MO by carefully reviewing and reflecting on the pathological differences between stages. 相似文献
82.
83.
Yukihiro Tsuchiya Fumitake Ishihara Goro Kajiyama Saburo Nakazawa Masao Otho Hiroshi Tanimura Yoshikazu Akura Minoru Harada Masabumi Hihara Yukio Kawai Yukihiro Kono Hajime Koshiyama Masahiro Morita Michiko Nakajima Kyoichiro Nishina Hiroshi Sagawa Terufumi Sakai Mitsuo Shoji Kayoko Sone Yoshihiro Sugimoto Keiichi Sugiyama Osamu Takahara Tomoo Takamura Susumu Tazuma Hideki Wakamatsu 《Journal of gastroenterology》1995,30(6):768-774
The use of bile acid dissolution therapy in extracorporeal shockwave lithotripsy of gallstones, remains controversial. Our
study examined whether chemolitholysis after sufficient disintegration enhanced stone clearance within 6 months of the first
lithotripsy. A total of 143 patients who developed one to three radiolucent stones measuring⪯30 mm in diameter were randomly
separated into two treatment groups: 47% were given lithotripsy alone, and 53% lithotripsy plus ursodeoxycholic acid (UDCA).
Repeated piezoelectric lithotripsy was given, with no limit on the total number of treatment sessions, to pulverize or disintegrate
stones into fragments<3 mm. Stones were disintegrated in 97% of all patients, and the fragments were ⪯2 mm in 50% of these
patients. According to an intention-to-treat analysis, 52% in the lithotripsy alone group and 58% in the UDCA group were free
of stones 6 months after the first lithotripsy (P=0.61). Of the patients with fragments⪯2 mm, 71% in the former and 86% in the latter group were free of stones 6 months after
the first lithotripsy, with no significant difference between the groups. Biliary pain occurred in 25% of all patients, including
3 with acute cholecystitis. We concluded that the sufficient disintegration of gallstones achieved with repeated lithotripsy
enhanced the early clearance of fragments, regardless of whether chemolitholysis was employed. 相似文献
84.
Metachronous solitary mediastinal lymph node metastases of hepatocellular carcinoma treated by video‐assisted thoracic surgery twice: Report of a case 下载免费PDF全文
Masatake Taniguchi Masanobu Hyodo Kenji Tezuka Shoichi Shinohara Hirofumi Hayashi Yasuhiro Inoue Hirotake Satoh Munetoshi Tsukahara Alan Kawarai Lefor Masaki Okada Yoshikazu Yasuda 《Asian journal of endoscopic surgery》2018,11(1):64-67
Solitary mediastinal lymph node metastasis of hepatocellular carcinoma (HCC) is rare. We report a case of metachronically solitary mediastinal metastases of HCC treated by video‐assisted thoracic surgery (VATS) twice. A 66‐year‐old man underwent repeated laparoscopic radiofrequency ablation or trans‐arterial catheter chemo‐embolization against HCC for more than 10 years. The level of alpha fetoprotein protein was elevated, and radiological modalities including FDG‐PET revealed solitary mediastinal tumor metachronically. VATS was performed bilaterally twice. The postoperative course was uneventful and there had no recurrence of extra‐hepatic metastases and tumor markers are within normal limits at 18 months after second VATS. VATS is a minimally invasive and useful procedure for solitary mediastinal lymph node metastasis of HCC. If primary HCC was controlled and lymph node metastasis was solitary, mediastinum lymphadenectomy using VATS might give good short and long term results. 相似文献
85.
86.
Yoshikazu Murawaki M.D. Sciichi Kato Chisato Hirayama 《Journal of gastroenterology》1991,26(4):465-471
To examine the synthesis of hepatic collagen in patients with alcoholic and nonalcoholic liver disease, liver biopsy specimens
were incubated in vitro with14C-proline, and the radioactivity of the newly synthesized protein-bound14C-hydroxyproline was measured. Mean hepatic collagen synthesis was 0.82±0.19 pmole of14C-hydroxyproline/g liver/2 h in control subjects without histological liver fibrosis. Hepatic collagen synthesis was increased
in patients with alcoholic and nonalcoholic liver diseases, especially in those with alcoholic fibrosis, alcoholic cirrhosis
and chronic active hepatitis. The raised collagen synthesis in alcoholic liver disease rapidly decreased after withdrawal
of alcohol. When alcoholic liver disease were compared with nonalcoholic liver disease, there was no significant difference
in hepatic collagen synthesis.
This work was supported in part by a grant-in-aid for EncourageMent of Young Scientists (No.57770489) from the Ministry of
Education, Science and Culture of Japan. 相似文献
87.
88.
Dr. Felix W. Leung MD Kenny C. Su MD Yoshikazu Yonel MD Edward Passaro Jr MD Paul H. Guth MD 《Digestive diseases and sciences》1993,38(7):1220-1223
In rat colon damaged by 10% acetic acid and by dinitrochlorobenzene, we test the following hypotheses: (1) mucosal hemodynamic changes are significantly different at the ulcer base, the ulcer margin, and the inflamed non-ulcer-bearing mucosa; and (2) these mucosal hemodynamic changes also vary with time after induction of the colonic injury. Mucosal hemodynamic changes were documented by reflectance spectrophotometry, and variations in gross mucosal morphology were confirmed by hematoxylin and eosin histologic sections. Results revealed that in the acute stage, the ulcer base, which was covered by necrotic debris, showed ischemia without congestion. The ulcer margin at the edge of the ulcer base showed ischemia with congestion. The nonulcerated mucosa, which appeared erythematous, showed increased perfusion. In the convalescent stage, all the altered perfusion patterns returned to normal. These observations offer plausible explanations for the variability in colonic perfusion observed in experimentally damaged colons. 相似文献
89.
A case of pulmonary embolic metastasis of choriocarcinoma presenting with multiple pulmonary infiltrative shadows] 总被引:1,自引:0,他引:1
Masaru Suzuki Tetsuya Kojima Hiroshi Saito Yoichi Nishiura Yoshikazu Kawakami 《Nihon Kokyūki Gakkai zasshi》2004,42(7):671-675
A 34-year-old woman visited our hospital complaining of dry cough. Chest radiography and computed tomography showed bilateral multiple infiltrative shadows over the lung field. After an initial diagnosis of pneumonia, antibiotics were administered, but the therapy failed to improve the symptoms and abnormalities observed on the chest radiograph. The patient was then admitted to our hospital. The bronchoalveolar lavage fluid (BALF) was slightly bloody, but we were not able to make any specific findings in BALF. In order to confirm the pathological diagnosis, video-assisted thoracoscopic lung biopsy was performed aiming at the right middle and lower lobes. There were bleeding pulmonary infarctions in a biopsy specimen from the right middle lobe. Atypical cells positive for human chorionic gonadotropin (hCG) proliferated in the pulmonary arteries, and so a diagnosis of pulmonary embolic metastasis of choriocarcinoma was made. After the diagnosis, it became clear that urine and serum hCG values were very high. The patient has since received systemic chemotherapy in the gynecology unit at our hospital. Pulmonary embolic metastasis of choriocarcinoma diagnosed by video-assisted thoracoscopic lung biopsy has never been reported in the literature. However, early hCG measurement may have detected this syndrome in the earlier stages, and pulmonary metastasis of choriocarcinoma should be considered in the differential diagnosis of women with past pregnancy presenting with intractable multiple pulmonary shadows. 相似文献
90.
Associations of hypertension and its complications with variations in the xanthine dehydrogenase gene 总被引:1,自引:0,他引:1
Jin Yang Kei Kamide Yoshihiro Kokubo Shin Takiuchi Takeshi Horio Tetsutaro Matayoshi Hisayo Yasuda Yoshikazu Miwa Masayoshi Yoshii Fumiki Yoshihara Satoko Nakamura Hajime Nakahama Hitonobu Tomoike Toshiyuki Miyata Yuhei Kawano 《Hypertension research》2008,31(5):931-940
Hyperuricemia and oxidative stress participate in the pathophysiology of hypertension and its complications. Xanthine dehydrogenase (XDH) produces urate and, in its oxidase isoform, reactive oxygen species. Here we have studied whether or not the genetic variations in XDH could be implicated in hypertension and its complications. By sequencing the promoter region and all exons of XDH in 48 subjects, we identified three missense mutations (G172R, A932T, N1109T) in a heterozygous state in addition to 34 variations, including 15 common single nucleotide polymorphisms (SNPs). The three missense mutations and eight common SNPs (11488C>G, 37387A>G, 44408A>G, 46774G>A, 47686C>T, 49245A>T, 66292C>G, and 69901A>C) were genotyped in 953 hypertensive Japanese subjects and in 1,818 subjects from a general Japanese population. Four hypertensive patients with rare missense mutations (G172R or N1109T) in homozygous form had severe hypertension. Multivariate logistic regression analysis showed a significant association of three SNPs with hypertension in men: 47686C>T (exon 22, odds ratio [OR]: 1.52, p = 0.047) and 69901A>C (intron 31, OR: 3.14, p = 0.039) in the recessive model, and 67873A>C (N1109T) (exon 31, OR: 1.84, p = 0.018) in the dominant model. After full adjustment for all confounding factors, only one polymorphism (69901A>C) was found to be associated with carotid atherosclerosis in the dominant model (p = 0.028). Multiple logistic regression analysis showed that one SNP (66292C>G) was significantly associated with chronic kidney disease (CKD: estimated creatinine clearance < 60 ml/min) in the recessive model (p = 0.0006). Our results suggest that genetic variations in XDH contribute partly to hypertension and its complications, including atherosclerosis and CKD. 相似文献