脑缺血实验模型的制作及头针治疗

以恒河猴为实验动物，采用介入方法行大脑中动脉栓塞术，建立局部脑缺血病理变化，并模拟国际标准化头穴方案取穴治疗，发现头针治疗有利于实验性脑缺血病的恢复。     

番泻叶浸剂灌肠在腹部手术后应用的临床与实验研究

目的：探讨番泻叶侵剂治疗腹部手术后胃肠道功能紊乱的疗效及其机理。方法：患者腹部手术后灌肠给番泻叶侵剂，观察术后腹部功能恢复情况，并进行了动物实验。结果：经治疗１３０例患者腹部手术后在加快肠鸣音出现和恢复，缩短排气、排便时间，减少切口感染等方面疗效显著。动物实验结果表明：该药对大鼠在体肠管运动有明显的增强作用（Ｐ〈０．０１）；有显著的增强离体大鼠回肠蠕动和增大收缩振幅的作用（Ｐ〈０．０５）；对在体小     

血清MIA检测在恶性黑素瘤诊断中的临床价值

探讨血清黑素抑制蛋白（ｍｅｌｏｎｏｍａ－ｉｎｈｉｂｉｔｉｎｇ ａｃｔｉｖｉｔｙ ｐｒｏｔｅｉｎ,ＭＩＡ）在恶性黑素瘤诊断中的价值。方法：采用ＥＬＩＳＡ方法,检测不同临床分期的黑素瘤及其他恶性肿瘤患者,以及正常人血清ＭＩＡ浓度。结果正常成人（ｎ＝２０）和肺癌（ｎ＝１０）、肝癌、（ｎ＝１２）结肠癌（ｎ＝１２）患者血清ＭＩＡ浓度全部低于正常（６．５ｎｇ／ｍｌ）水平,黑素瘤患者血清ＭＩＡ浓度明显升高,阳性     

儿童功能性消化不良与幽门螺杆菌感染的关系

目的探讨儿童功能性消化不良与幽门螺杆菌（HP）感染的关系。方法用ELISA法和胃液尿素酶试验检测163例功能性消化不良和54例健康儿童的HP感染情况。结果血清HP-IgG阳性申功能性消化不良组高于对照组（43．6％:14.8％，X2＝14．7，ｐ＜0.01），尿素酶试验阳性率功能性消化不良组也高于对照组（15．3％:3．7％，x2＝5．07，p＜o．05）。内镜检查15例患儿中，慢性胃炎12例（占80％）。经抗HP治疗功能性消化不良症状消失。结论儿童功能性消化不良与HP感染相关，HP是该疾病的主要病因之一。     

Expression of c-erbB-2 and PCNA in cervical adenocarcinoma and its signification

Objective: To investigate the significance of c-erbB-2 and PCNA expression in adenocarcinoma. Methods: Expression of c-erbB-2 and PCNA in 74 cases of adenocarcinoma of the uterine cervix was examined by immunohistochemistry. Results: The expression of c-erbB-2 was detected in 34 cases. The positive staining of c-erbB-2 was associated with increased lymph node metastasis (57.1% Vs 24.0%, P=0.041) and lower 5-year survival rate (32.4% Vs 58.9%, P=0.008). The average PCNA labeling index (PCNA LI) was 40.6% (0.1%–91.4%). High PCNA LI was associated with lymph node metastasis (56.4% Vs 38.5%, P=0.016) and lower 5-year survival rate (28.7% Vs 64.4%, P=0.005). Positive staining of c-erbB-2 were associated with high PCNA LI (44.7% Vs 34.6% P=0.003). Conclusions: c-erbB-2 and PCNA LI were associated with malignant biological behavior and poor prognosis of patients with cervical adenocarcinoma.     

Intravenous Leiomyomatosis of the Uterus

Three cases of intravenous leiomyomatosis (IVL) of the uterus, a rare benign smooth-muscle tumor, are described. A preoperative diagnosis of IVL was not made in any of the patients, all of which presented with a pelvic mass with the presumptive diagnosis of leiomyoma. Surgical exploration confirmed the presence of uterine mass and two of the three cases showed extra-uterine extension into the ovarian or uterine veins. Histological examination demonstrated a fascicular pattern of bland spindle-shaped smooth-muscle cells, which extended to veins inside the myometrium or to extrauterine veins. This was confirmed by immunohistochemical stain for desmin and factor VIII. Despite their histological benignity, these lesions have a tendency to metastasize and are closely related to the conditions called “benign metastasizing leiomyoma” and “intracaval mass and cardiac extension”. The primary treatment of IVL is hysterectomy and excision of any extrauterine tumor, when technically feasible. Anti-estrogenic therapy has been suggested as potentially useful in controlling of unresectable tumor. According to the literature, the follow-up must be long and periodic postoperative ultrasonic or magnetic nuclear resonance imaging studies may be useful in detecting growth of residual intravascular tumor.     

Chemical constituents of Conyza blinii Lévl.]

Five compounds were isolated from the aerial part of Conyza blinii. On the basis of physicochemical properties and spectroscopic analysis, they were identified as alpha-spinasterol, 5, 8-dihydroxy-7, 3', 4'-trimethoxyflavone, caffeic acid, quercetin and syringic acid. All these compounds were isolated from the plant of C. blinii for the first time.     

几种癌细胞的胞质桥粒及其形成的电镜观察

目的探讨癌细胞胞质桥粒及其形成的机制和意义。方法应用透射电子显微镜观察人体卵巢癌细胞、外阴癌细胞、子宫内膜癌细胞和子宫颈癌细胞的超微结构。结果发现这些癌细胞不仅有表面的桥粒，而且都有胞质桥粒。大多数胞质桥粒存在于胞膜内面或核膜外周附近的胞质内，有形成完好的，也有正在形成中的。胞质桥粒周围见有较多的多聚核糖体、张力微丝和粗面内质网。结论胞质桥粒广泛存在于人体卵巢癌细胞、外阴癌细胞、子宫内膜癌细胞和子宫颈癌细胞。我们推测胞质桥粒的形成是在癌细胞完全分裂之后根据细胞自身机能的需要而产生的。     

睾丸精原细胞瘤的疗效及预后因素分析

作者分析了５０例睾丸精原细胞瘤的疗效及预后因素。术后单纯放疗２４例，放疗加化疗１３例，两组的５年、１０年生存率分别为９１．７％及８４．３％，Ｐ＞０．０５，单纯化疗１３例，５年生存率为９０．９％，与放疗、化疗组相比，Ｐ＞０．０５。年龄＜４０岁和≥４０岁的病例的５年、１０年生存率分别为９５．７％和６８．８％，Ｐ＜０．０５。结果表明，Ⅰ期睾丸精原细胞瘤病例手术后宜行单纯放疗，若复发，可行放疗加化疗；年龄较轻的病例生存率较高；β－绒毛膜促性腺激素水平、隐睾及隐睾部位与生存率关系不大。     

复方益智汤对小鼠学习和记忆能力的影响

采用跳台实验和水迷宫实验方法，观察复方益智汤对由樟柳碱、环已酰亚胺和３０％乙醇造成的小鼠记忆障碍病理模型的影响。结果表明，复方益智汤可不同程度地改善小鼠学习和记忆的获得、巩固和再现能力。