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91.
上海社区老年人用药安全及影响因素分析 总被引:11,自引:0,他引:11
目的:了解上海社区老年人群的用药安全情况及其影响因素,方法:以整群抽样的方法抽取上海市黄浦区两个居民委员会2985名60岁以上的居民进行问卷调查,了解其疾病和用药情况,用药反应,对安全用药的知识,态度,行为,以及影响其用药行为的因素,结果:被调查中高血压、冠心病、消化系统疾病和呼吸系统疾病的患病率分别为35.93%、10.67%、5.70%和3.71%。抗高血压药,心脑血管病药,消化系统疾病和呼吸系统疾病的患病率分别为35.93%、10.67%、5.70%和3.71%,抗高血压药、心脑血管病药,消化系统药和抗生素的使用率分别为31.72%、16.20%、2.43%和2.11%,过去30天内,51.33%的被调查用过药物,用药不良反应发生率为2.06%,对用药安全的正确知识,态度,行为率分别为71.62%、69.39%及60.67%,影响药物选择的因素中医生占88.19%,结论:老年人的用药安全仍存在问题,有待改进,医生是影响老年人药选择的最主要因素。 相似文献
92.
T. V. Peker C. Pelin H. B. Turgut A. Anıl A. Sevim 《European archives of oto-rhino-laryngology》1998,255(8):391-395
Since it covers the lateral wall of the mastoid air system, the suprameatal triangle is of importance to otologic surgeons
during mastoidectomy. Because of this clinical importance, topographic anatomy of the suprameatal spine and depression was
studied on Anatolian skulls. In all, 363 male and 231 female skulls were studied. The most prevalent type of suprameatal spine
resembled a crest and was found in both sexes on the right (77.6%) and left (80%) sides. The absence of a suprameatal depression
was significantly higher in females (right 9.1%; left 8.7%) than in males (right 1.7%; left 2.5%). Suprameatal depressions
were mostly shallow in female subjects, but were mostly observed in males to be at a medium depth or deep.
Received: 5 January 1998 / Accepted: 19 March 1998 相似文献
93.
赵毅 《中国医疗器械杂志》2005,29(6):456-457
来用锁相环IC CD4046设计的心率显示报警电路,用于数台老式监护仪的改造中,获得成功. 相似文献
94.
A. C. Iplikçioğlu M. A. Bayar F. Kökeş B. Yildiz C. Gökçek Z. Buharali 《Neuroradiology》1994,36(1):31-32
We report a fluid level in an acute extradural haematoma developing after placement of a ventriculoperitoneal shunt for hydrocephalus. This fluid level was thought to be due to a mixture of blood and cerebrospinal fluid. 相似文献
95.
Jiang He Mary Rusckowski Yi Wang Shuping Dou Xinrong Liu Surong Zhang Guozheng Liu Donald J. Hnatowich 《Molecular imaging and biology》2007,9(1):17-23
Objective Pretargeting with radioactivity has significantly improved tumor to normal tissue radioactivity ratios over conventional antibody
imaging in both animal studies and clinical trials. This laboratory is investigating DNA analogues such as phosphorodiamidate
morpholinos (MORFs) for pretargeting using technetium-99m (99mTc) for detection. However, the unique properties of fluorescence activation and quenching combined with oligomers with their
unique properties of hybridization may be particularly useful when used together for pretargeting with optical detection.
The use of linear fluorophore-conjugated oligomer duplexes have been little used in animals, and to our knowledge, have not
previously been considered for pretargeting applications.
Methods A MORF/cDNA pair was selected such that when hybridized, the fluorescence of the Cy5.5-conjugated 25 mer MORF (Cy5.5–MORF25)
is inhibited with a BHQ3-conjugated 18 mer complementary DNA (BHQ3–cDNA18). The short BHQ3–cDNA18 was selected to dissociate
in the presence of a long cMORF25 in the pretargeted tumor, thus releasing the inhibitor from the Cy5.5 emitter. In this manner,
the Cy5.5 fluorescence will be inhibited everywhere but in the target. The dissociation was first examined in vitro by adding the duplex to the cMORF25 both in solution and immobilized on polystyrene microspheres and by surface plasmon resonance
(SPR). Thereafter, biotinylated cMORF25 immobilized on streptavidin polystyrene microspheres were administered intramuscularly
in one thigh of hairless SKH-1 mice as target while an identical weight of the identical microspheres but without the cMORF25
was administered in the contralateral thigh as control. The animals then received IV the Cy5.5–MORF25/BHQ3–cDNA18 duplex or
equal molar dosage of single-chain Cy5.5–MORF25 and were imaged.
Results The SPR studies showed that the immobilized cDNA18 rapidly captured the flowing MORF25 to provide a duplex with a slow dissociation
rate constant. Furthermore, when cMORF25 was next allowed to flow over the now immobilized duplex, the cDNA18 was unable to
prevent dissociation of the heteroduplex and the formation and release of the cMORF25-MORF25 homoduplex. Images of animals
obtained soon after receiving the Cy5.5–MORF25 singlet showed intense whole body fluorescence obscuring the target thigh.
However, only 5 minutes after receiving the Cy5.5–MORF25/BHQ3–cDNA18 duplex, the target thigh was clearly visible along with
only the kidneys.
Conclusions This first study of optical pretargeting provides a proof of concept that oligomer pretargeting found to be useful with radioactivity
detection is applicable with fluorescent detection as well. In addition, our results demonstrate that by using linear oligomers
for optical pretargeting, chain lengths (and base sequences) may be manipulated to provide duplexes with stabilities and fluorescence
inhibition optimized for pretargeting and other in vivo applications of optical imaging. 相似文献
96.
97.
江汉平原鼠间流行性出血热感染研究 总被引:4,自引:0,他引:4
为了解湖北省江汉平原流行性出血热(EHF)疫区鼠间感染状况,采用挖洞法捕鼠,鉴定鼠种、性别和年龄,检查有无皮肤破伤,检测EHFV抗原抗体。结果,黑线姬鼠和褐家鼠占所捕鼠的69.7%和23.6%,其EHFV感染率分别为21.8%和30.9%。鼠间EHFV感染,成年鼠显著高于亚成年鼠和幼年鼠,感染率分别为40.8%、17.0%和12.4%;皮肤破伤鼠感染率45.9%,显著高于非皮肤破伤鼠的13.9%。感染鼠以窝为单位具有明显的窝聚集性,而感染鼠窝在地理空间上则随机分布。感染鼠血清分型,黑线姬鼠以野鼠型为主,少数为未定型;褐家鼠以家鼠型为主,亦有少数未定型。这表明,江汉平原EHF疫区是以黑线姬鼠和褐家鼠为主要宿主动物的家野混合型疫区;年龄、皮肤破伤和密切接触是该疫区鼠间EHFV传播的重要因素。 相似文献
98.
99.
100.
脾动脉栓塞治疗外伤性脾破裂28例临床疗效观察 总被引:3,自引:0,他引:3
目的:探讨脾动脉栓塞术对外伤性脾破裂的疗效及并发症的处理。方法:采用Seldinger法行脾动脉栓塞术治疗外伤性脾破裂28例。结果:所有患者出血立即停止,其中4例行2次栓塞。28例均有脾区疼痛,22例发热。脾动脉栓塞5天后血小板、白细胞上升近1倍,7天后恢复至正常范围。28例随访6-36月,查免疫球蛋白、CT等结果满意,未有再出血及发生暴发性感染。结论:脾动脉栓塞不但有良好的止血作用,而且能保留脾脏的免疫功能,可在非手术治疗失败时选用,是外伤性脾破裂的一种有效治疗方法。 相似文献