全文获取类型
收费全文 | 2973篇 |
免费 | 381篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 44篇 |
儿科学 | 94篇 |
妇产科学 | 66篇 |
基础医学 | 517篇 |
口腔科学 | 68篇 |
临床医学 | 367篇 |
内科学 | 526篇 |
皮肤病学 | 26篇 |
神经病学 | 364篇 |
特种医学 | 93篇 |
外科学 | 352篇 |
综合类 | 64篇 |
一般理论 | 3篇 |
预防医学 | 277篇 |
眼科学 | 82篇 |
药学 | 262篇 |
中国医学 | 1篇 |
肿瘤学 | 159篇 |
出版年
2021年 | 41篇 |
2020年 | 29篇 |
2019年 | 48篇 |
2018年 | 48篇 |
2017年 | 29篇 |
2016年 | 41篇 |
2015年 | 40篇 |
2014年 | 64篇 |
2013年 | 106篇 |
2012年 | 153篇 |
2011年 | 160篇 |
2010年 | 73篇 |
2009年 | 66篇 |
2008年 | 122篇 |
2007年 | 141篇 |
2006年 | 128篇 |
2005年 | 104篇 |
2004年 | 110篇 |
2003年 | 84篇 |
2002年 | 109篇 |
2001年 | 98篇 |
2000年 | 88篇 |
1999年 | 92篇 |
1998年 | 65篇 |
1997年 | 44篇 |
1996年 | 22篇 |
1995年 | 49篇 |
1994年 | 27篇 |
1993年 | 50篇 |
1992年 | 66篇 |
1991年 | 65篇 |
1990年 | 59篇 |
1989年 | 69篇 |
1988年 | 71篇 |
1987年 | 72篇 |
1986年 | 62篇 |
1985年 | 66篇 |
1984年 | 35篇 |
1983年 | 47篇 |
1981年 | 31篇 |
1980年 | 32篇 |
1979年 | 56篇 |
1978年 | 31篇 |
1977年 | 27篇 |
1976年 | 26篇 |
1975年 | 28篇 |
1974年 | 31篇 |
1973年 | 35篇 |
1972年 | 32篇 |
1970年 | 21篇 |
排序方式: 共有3365条查询结果,搜索用时 62 毫秒
71.
Global profiling of Shewanella oneidensis MR-1: expression of hypothetical genes and improved functional annotations 总被引:1,自引:0,他引:1 下载免费PDF全文
Kolker E Picone AF Galperin MY Romine MF Higdon R Makarova KS Kolker N Anderson GA Qiu X Auberry KJ Babnigg G Beliaev AS Edlefsen P Elias DA Gorby YA Holzman T Klappenbach JA Konstantinidis KT Land ML Lipton MS McCue LA Monroe M Pasa-Tolic L Pinchuk G Purvine S Serres MH Tsapin S Zakrajsek BA Zhu W Zhou J Larimer FW Lawrence CE Riley M Collart FR Yates JR Smith RD Giometti CS Nealson KH Fredrickson JK Tiedje JM 《Proceedings of the National Academy of Sciences of the United States of America》2005,102(6):2099-2104
72.
Alison M. Dines David M. Wood Miguel Galicia Christopher M. Yates Fridtjof Heyerdahl Knut Erik Hovda Isabelle Giraudon Roumen Sedefov Paul I. Dargan Euro-DEN Research Group 《Journal of medical toxicology》2015,11(4):415-421
Cannabis is the most commonly used illicit drug in Europe, and is generally regarded
as having low acute toxicity. We present the findings of the first 6 months of data collection from
the Euro-DEN project on presentations related to cannabis use to further understand the acute
toxicity related to the use of cannabis. Data was extracted on clinical features, treatment and
outcome from the Euro-DEN minimum dataset for all cases of acute recreational drug toxicity reported
1st October 2013 to 31st March 2014 for all cannabis-related presentations. Of 2198 presentations
reported by 14 of the 16 Euro-DEN centres, 356 (16.2 %) involved cannabis either alone or together
with other drugs/alcohol. There were 36 that involved lone use of cannabis (1.6 % of all
presentations). Of the 35 non-fatal lone cannabis presentations, the most commonly reported features
were neuro-behavioural (agitation/aggression 8 (22.9 %), psychosis 7 (20.0 %), anxiety 7 (20.0 %))
and vomiting 6 (17.1 %). Most patients (25, 71.4 %) received no treatment and 30 (85.7 %) were
discharged/self-discharged from the ED. There was one fatality amongst these lone-cannabis cases: an
18-year-old male collapsed with an asystolic cardiac arrest whilst smoking cannabis and suffered
hypoxic brain injury related to prolonged cardiac arrest. THC was detected in a urine sample taken
at ED arrival; no other drugs were detected. Lone acute cannabis toxicity was typically associated
with neuro-behavioural symptoms and vomiting. Although uncommon, severe toxicity including
cardiovascular toxicity and death may be under-recognised, and it is important that Emergency
Physicians are aware of this. 相似文献
73.
Gabriele C. DeLuca Richard L. Yates Harry Beale Sarah A. Morrow 《Brain pathology (Zurich, Switzerland)》2015,25(1):79-98
Cognitive impairment is a common and debilitating feature of multiple sclerosis (MS) that has only recent gained considerable attention. Clinical neuropsychological studies have made apparent the multifaceted nature of cognitive troubles often encountered in MS and continue to broaden our understanding of its complexity. Radiographic studies have started to decipher the neuroanatomic substrate of MS‐related cognitive impairment and have shed light onto its pathogenesis. Where radiographic studies have been limited by inadequate resolution or non‐specificity, pathological studies have come to the fore. This review aims to provide an overview of the nature of cognitive impairment typically seen in MS and to explore the literature on imaging and pathological studies relevant to its evolution. In particular, the relative contributions of gray (ie, cerebral cortex, hippocampus, thalamus and basal ganglia) and white matter to MS‐related cognitive impairment will be discussed and the importance of interconnectivity between structures highlighted. The pressing need for longitudinal studies combining standardized neuropsychometric, paraclinical and radiographic outcomes obtained during life with post‐mortem tissue analysis after death is presented. 相似文献
74.
A J Yates G E Gutierrez I R Garrett J J Mencel G W Nuss A B Schreiber G R Mundy 《Endocrinology》1990,126(6):2845-2849
A new analog of salmon calcitonin (N alpha-propionyl Di-Ala1,7,des-Leu19 sCT; RG-12851; here termed CTR), which lacks the ring structure of native calcitonin, was tested for biological activity in several in vitro and in vivo assay systems. The analog (CTR) and salmon calcitonin (sCT) stimulated kidney cell adenylate cyclase activity and inhibited bone resorption in organ cultures of fetal rat long bones with similar potencies and efficacies. Furthermore, CTR and sCT, at similar doses, induced comparable hypocalcemic responses in mice following sc injection or infusions. However, unlike sCT, CTR did not induce anorexia and weight loss in rats following sc injection. These data suggest that the ring structure of sCT may be important for the anorexigenic effect but is not required for effect on bone resorption or calcium homeostasis. Clinical studies appear warranted as, potentially, CTR might induce fewer side effects than does sCT. 相似文献
75.
Clint Douglas Diana Schmalkuche Debra Nizette Patsy Yates Ann Bonner 《Collegian (Royal College of Nursing, Australia)》2018,25(4):363-370
Background
Nurse-led services are expanding in Australia, yet current information about the scope and nature of these services is lacking. The need for more coordinated service planning and systematic evaluation prompted a scoping study to inform future development.Aim
To provide a comprehensive profile of nurse-led services in the Queensland public health system.Methods
A scoping study of 257 nurse-led services was conducted using an online survey distributed through each Hospital and Health Service in Queensland. Service level data were collected on structure, process and outcome evaluation, as well as enablers and barriers to sustainability of care delivery models.Findings
There is a diverse and growing range of nurse-led services across the state that have evolved to meet the dynamic needs of their communities. Increasingly, registered nurses are rising to the challenge of providing equitable and accessible healthcare in ways that transcend traditional professional or care setting boundaries. The major challenges for sustainability were funding and resource limitations, particularly for developing service capacity to meet growing demands. There were also tensions around the need for ongoing negotiation and review of nurse-led services with medical and administrative stakeholders.Discussion
Findings underscore the need for a modernised regulatory and policy framework to support sustainable nurse-led services and allow nurses to work to their full potential to optimise outcomes for the community.Conclusion
Nurse-led services are the sleeping giant of healthcare reform in Australia. Now is the time for policy and practice changes that will realise the transformative potential of nurse-led care. 相似文献76.
Ly Thuy Nguyen Kimberly Alexander Patsy Yates 《Journal of pain and symptom management》2018,55(6):1459-1472
Objectives
To assess the feasibility of conducting a trial of a psychoeducational intervention involving the provision of tailored information and coaching to improve management of a cancer-related symptom cluster (fatigue, pain, and sleep disturbance) and reduce symptom cluster impacts on patient health outcomes in the Vietnamese context and to undertake a preliminary evaluation of the intervention.Methods
A parallel-group single-blind pilot quasi-experimental trial was conducted with 102 cancer patients in one Vietnamese hospital. The intervention group received one face-to-face session and two phone sessions delivered by a nurse one week apart, and the comparison group received usual care. Patient outcomes were measured at baseline before the chemotherapy cycle and immediately preceding the next chemotherapy cycle. Separate linear mixed models were used to evaluate the impact of the intervention on total symptom cluster severity, symptom scores, functional status, depressive symptoms, and health-related quality of life.Results
The study design was feasible with a recruitment rate of 22.6% and attrition rate of 9.8%. Compared to the control group, the intervention group showed a significant reduction in symptom cluster severity, fatigue severity, fatigue interference, sleep disturbance, depression, and anxiety. Significant differences were not observed for pain severity, pain interference, functional status, and health-related quality of life. The intervention was acceptable to the study population, with a high attendance rate of 78% and adherence rate of 95.7%.Conclusion
On the basis of the present study findings, future randomized controlled trials are needed to test the effectiveness of a symptom cluster psychoeducational intervention in Vietnam. 相似文献77.
78.
William R. Yates Maureen Martin Douglas LaBrecque Don Hillebrand Michael Voigt Debra Pfab 《Alcoholism, clinical and experimental research》1998,22(2):513-517
Six months of abstinence from alcohol is a commonly used criterion for liver transplantation eligibility for patients with alcoholic cirrhosis. There is limited evidence to document the validity of this criterion with regard to risk of alcoholism relapse. Ninety-one patients with alcoholic cirrhosis were interviewed for relapse risk using the High Risk Alcoholism Relapse (HRAR) Scale. The HRAR model can be used to predict relapse risk independent of duration of sobriety and therefore can be used to examine the validity of the 6 months of abstinence criteria in this clinical population. The two methods demonstrated poor to fair agreement. Agreement was highest with a cutoff allowing a 5% 6-month relapse risk when 79% agreement ( k = 0.56) was demonstrated between the two methods. Using the 6-month abstinence criterion alone disallows a significant number of candidates who have a low relapse risk based on their HRAR score. The validity of the 6-month abstinence criterion is supported somewhat by comparison with the HRAR model. However, use of the 6-month abstinence criterion alone forces a significant number of patients with a low relapse risk by HRAR to wait for transplant listing. A relapse risk model based on an estimate of alcoholism severity in addition to duration of sobriety may more accurately select patients who are most likely to benefit from liver transplantation. 相似文献
79.
80.
Tandem quadrupole Fourier-transform mass spectrometry of oligopeptides and small proteins. 总被引:2,自引:7,他引:2
D F Hunt J Shabanowitz J R Yates rd N Z Zhu D H Russell M E Castro 《Proceedings of the National Academy of Sciences of the United States of America》1987,84(3):620-623
Modifications to the newly developed tandem quadrupole Fourier-transform mass spectrometer have made it possible to record mass spectra on oligopeptides and small proteins in the mass range between 2 and 13 kDa. 相似文献