全文获取类型
收费全文 | 5076篇 |
免费 | 260篇 |
国内免费 | 40篇 |
专业分类
耳鼻咽喉 | 39篇 |
儿科学 | 82篇 |
妇产科学 | 60篇 |
基础医学 | 615篇 |
口腔科学 | 61篇 |
临床医学 | 300篇 |
内科学 | 1291篇 |
皮肤病学 | 120篇 |
神经病学 | 473篇 |
特种医学 | 372篇 |
外科学 | 882篇 |
综合类 | 28篇 |
一般理论 | 1篇 |
预防医学 | 135篇 |
眼科学 | 59篇 |
药学 | 300篇 |
中国医学 | 12篇 |
肿瘤学 | 546篇 |
出版年
2023年 | 23篇 |
2022年 | 68篇 |
2021年 | 136篇 |
2020年 | 76篇 |
2019年 | 90篇 |
2018年 | 120篇 |
2017年 | 117篇 |
2016年 | 129篇 |
2015年 | 116篇 |
2014年 | 150篇 |
2013年 | 193篇 |
2012年 | 318篇 |
2011年 | 371篇 |
2010年 | 224篇 |
2009年 | 189篇 |
2008年 | 342篇 |
2007年 | 342篇 |
2006年 | 377篇 |
2005年 | 377篇 |
2004年 | 323篇 |
2003年 | 297篇 |
2002年 | 281篇 |
2001年 | 38篇 |
2000年 | 35篇 |
1999年 | 60篇 |
1998年 | 67篇 |
1997年 | 46篇 |
1996年 | 53篇 |
1995年 | 48篇 |
1994年 | 40篇 |
1993年 | 46篇 |
1992年 | 35篇 |
1991年 | 31篇 |
1990年 | 26篇 |
1989年 | 28篇 |
1988年 | 15篇 |
1987年 | 18篇 |
1986年 | 7篇 |
1985年 | 15篇 |
1984年 | 15篇 |
1983年 | 11篇 |
1982年 | 14篇 |
1981年 | 12篇 |
1980年 | 9篇 |
1979年 | 7篇 |
1978年 | 8篇 |
1977年 | 5篇 |
1975年 | 3篇 |
1972年 | 3篇 |
1966年 | 3篇 |
排序方式: 共有5376条查询结果,搜索用时 31 毫秒
71.
72.
Satoshi Kutsuna Yasuyuki Kato Meng Ling Moi Akira Kotaki Masayuki Ota Koh Shinohara Tetsuro Kobayashi Kei Yamamoto Yoshihiro Fujiya Momoko Mawatari Tastuya Sato Junwa Kunimatsu Nozomi Takeshita Kayoko Hayakawa Shuzo Kanagawa Tomohiko Takasaki Norio Ohmagari 《Emerging infectious diseases》2015,21(3):517-520
After 70 years with no confirmed autochthonous cases of dengue fever in Japan, 19 cases were reported during August–September 2014. Dengue virus serotype 1 was detected in 18 patients. Phylogenetic analysis of the envelope protein genome sequence from 3 patients revealed 100% identity with the strain from the first patient (2014) in Japan. 相似文献
73.
Yosuke Takeuchi Shuei Murahashi Yasuyuki Hara Mitsuharu Ueda 《Internal medicine (Tokyo, Japan)》2021,60(6):935
Cerebral rheumatoid vasculitis (CRV) is a rare, fatal, and diagnostically challenging disorder. We herein report an 81-year-old woman with a 4-year history of rheumatoid arthritis who presented with a fever, progressive disturbance of consciousness, high level of rheumatoid factor, and hypocomplementemia. The enhancement of the perforating branches in the left middle cerebral artery led us to suspect CRV. A brain biopsy could not be performed. After we intensified steroid therapy, the size of the cerebral lesions temporarily decreased. However, recurrence in the left frontal lobe occurred one month later, and the patient subsequently died. Early intensive treatments may be needed for CRV. 相似文献
74.
Yasuharu Matsunaga-Lee MD Yasuyuki Egami MD Kohei Ukita MD Akito Kawamura MD Hitoshi Nakamura MD Yutaka Matsuhiro MD Koji Yasumoto MD Masaki Tsuda MD Akihiro Tanaka MD Naotaka Okamoto MD Masamichi Yano MD PhD Ryu Shutta MD Yasushi Sakata MD PhD FACC FESC Masami Nishino MD PhD FACC FESC Jun Tanouchi MD PhD 《Journal of cardiovascular electrophysiology》2021,32(1):58-66
75.
Influence of inhaled corticosteroids on community-acquired pneumonia in patients with bronchial asthma 总被引:1,自引:0,他引:1
To M To Y Yamada H Ogawa C Otomo M Suzuki N Sano Y 《Internal medicine (Tokyo, Japan)》2004,43(8):674-678
OBJECTIVE: The aim of the present study was to evaluate the influence of inhaled corticosteroids (ICS) on community-acquired pneumonia (CAP) in patients with asthma. PATIENTS AND METHODS: All asthmatic patients who required hospitalization for CAP from the beginning of 1989 through December 2001 were enrolled in this retrospective study. Patients who used oral corticosteroids daily were excluded. Patients were divided into two groups based on whether or not they used ICS, and we analyzed clinical characteristics of the pneumonia. Sixty-two patients (28 males, 34 females; mean age, 54.5 years) were enrolled in this study. Thirty-seven of 62 patients used ICS, with the mean dosage being 777.9 microg/day. RESULTS: We found no significant differences between the two groups with regard to mean age, serum albumin level, duration of asthma, pulmonary function and frequency of intravenous infusion of corticosteroids in the outpatient department. There were no significant differences in body temperature, white blood cell count, and CRP value upon admission between the two groups. Differences were not significant in the period of resolution of the pneumonia or in the frequency of pathogens identified between the two groups. CONCLUSION: ICS therapy appears to have no influence on CAP in patients with asthma. We recommend that ICS should be continued to control asthma with adequate antibiotic therapy when asthmatic patients have CAP. 相似文献
76.
Shigemoto Yoko Matsuda Hiroshi Kimura Yukio Chiba Emiko Ohnishi Masahiro Nakaya Moto Maikusa Norihide Ogawa Masayo Mukai Yohei Takahashi Yuji Sako Kazuya Toyama Hiroshi Inui Yoshitaka Taki Yasuyuki Nagayama Hiroshi Ono Kenjiro Kono Atsushi Sekiguchi Kenji Hirano Shigeki Sato Noriko 《Annals of nuclear medicine》2022,36(5):460-467
Annals of Nuclear Medicine - Although previous studies have investigated age and gender effects on striatal subregional dopamine transporter (DaT) binding, these studies were mostly based on a... 相似文献
77.
Vascular endothelial growth factor (VEGF) is a survival factor in endothelial cells and a promoter of angiogenesis that reportedly plays a pivotal role protecting against injury. In aged humans and animals, lung injuries are generally more serious and cause higher mortality. We thus hypothesized that the expression of VEGF and its related molecules in the lung declines with age. In this study, we first examined the expression of VEGF family (VEGF-A, -B, -C and -D), VEGF-A isoforms (VEGF120, 164, 188), and VEGF-specific receptors (VEGFR-1: Flt-1; VEGFR-2: Flk-1 and VEGFR-3: Flt-4) by quantitative RT-PCR in lungs from young and old mice. Expression of all these except for VEGF-D was significantly lower in old mice than in young mice. We then subjected young and old mice to lipopolysaccaride (LPS)-induced lung injury. Old animals demonstrated poor survival and prolonged lung inflammation when compared with young counterparts. At 24 and 72 h after intratracheal LPS administration, expression of the examined factors was down-regulated in the lungs irrespective of age. In conclusion, pulmonary expression of the VEGF family and their receptors declines with age, and is further down-regulated in LPS-induced lung injury, although the mechanism of age- and/or injury-related down-regulation of VEGF remains unknown. 相似文献
78.
A giant retention cyst of the pancreas (cystic dilatation of dorsal pancreatic duct) associated with pancreas divisum 总被引:1,自引:0,他引:1
Morise Z Yamafuji K Tsuji T Asami A Takeshima K Hayashi N Baba H Yoshida F Abe Y Tokura Y 《Journal of gastroenterology》2002,37(12):1079-1082
We describe a rare case of pancreas divisum associated with a giant retention cyst (cystic dilatation of the dorsal pancreatic
duct), presumably formed following obstruction of the minor papilla. The patient was treated by pancreatico(cysto)jejunostomy.
A 50-year-old man was admitted with complaints of increasing upper abdominal distension and body weight loss. There was no
previous history of pancreatitis, gallstones, drinking, or abdominal injury. An elastic-hard tumor-like resistance was palpable
in the upper abdomen. Computed tomography and ultrasound (US) examinations revealed a giant cystic lesion expanding from the
pancreas head to the tail. Endoscopic retrograde cholangiopancreatography findings showed a looping pancreatic duct which
drained only the head and uncinate process of the pancreas to the main papilla. A US-guided puncture to the cystic lesion
revealed that the lesion continued to the main pancreatic duct in the tail of pancreas. The lesion was connected to a small
cystic lesion, which was located inside the minor papilla, and ended there. The amylase level in liquid aspirated from the
cyst was 37 869 IU/l, and the result of cytological examination of the liquid showed class II. A pancreatico(cysto)jejunostomy
was performed, with the diagnosis being pancreas divisum associated with a retention cyst following obstruction of the minor
papilla. The histological findings of a specimen from the cyst wall revealed that the wall was a pancreatic duct covered with
mildly inflammatory duct epithelium; there was no evidence of neoplasm. The patient is currently well, and a CT examination
2 years after the operation showed disappearance of the cyst and normal appearance of the whole pancreas.
Received: April 24, 2001 / Accepted: September 14, 2001 相似文献
79.
Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves 总被引:7,自引:0,他引:7
Amoh Y Li L Campillo R Kawahara K Katsuoka K Penman S Hoffman RM 《Proceedings of the National Academy of Sciences of the United States of America》2005,102(49):17734-17738
The hair follicle bulge area is an abundant, easily accessible source of actively growing, pluripotent adult stem cells. Nestin, a protein marker for neural stem cells, also is expressed in follicle stem cells and their immediate, differentiated progeny. The fluorescent protein GFP, whose expression is driven by the nestin regulatory element in transgenic mice, served to mark the follicle cell fate. The pluripotent nestin-driven GFP stem cells are positive for the stem cell marker CD34 but negative for keratinocyte marker keratin 15, suggesting their relatively undifferentiated state. These cells can differentiate into neurons, glia, keratinocytes, smooth muscle cells, and melanocytes in vitro. In vivo studies show the nestin-driven GFP hair follicle stem cells can differentiate into blood vessels and neural tissue after transplantation to the subcutis of nude mice. Equivalent hair follicle stem cells derived from transgenic mice with beta-actin-driven GFP implanted into the gap region of a severed sciatic nerve greatly enhance the rate of nerve regeneration and the restoration of nerve function. The follicle cells transdifferentiate largely into Schwann cells, which are known to support neuron regrowth. Function of the rejoined sciatic nerve was measured by contraction of the gastrocnemius muscle upon electrical stimulation. After severing the tibial nerve and subsequent transplantation of hair follicle stem cells, walking print length and intermediate toe spread significantly recovered, indicating that the transplanted mice recovered the ability to walk normally. These results suggest that hair follicle stem cells provide an important, accessible, autologous source of adult stem cells for regenerative medicine. 相似文献
80.
Yasuyuki Saito Chandra Sekhar Boddupalli Chiara Borsotti Markus G. Manz 《European journal of immunology》2013,43(6):1651-1658
Lymphoid‐tissue dendritic cells (DCs) are short‐lived and need to be continuously replenished from bone marrow‐derived DC progenitor cells. Fms‐related tyrosine kinase 3 is expressed during cellular development from hematopoietic progenitors to lymphoid‐tissue DCs. Fms‐related tyrosine kinase 3 ligand (Flt3L) is an essential, nonredundant cytokine for DC progenitor to lymphoid tissue DC differentiation and maintenance. However, which cells contribute to Flt3L production and how Flt3L cytokine levels are regulated in steady state and during immune reactions remains to be determined. Here we demonstrate that besides nonhematopoietic cells, WT T cells produce Flt3L and contribute to the generation of both classical DCs (cDCs) and plasmacytoid DCs in Flt3L?/? mice. Upon stimulation in vitro, CD4+ T cells produce more Flt3L than CD8+ T cells. Moreover, in vivo stimulation of naïve OT‐II CD4+ T cells with OVA leads to increase of pre‐cDCs and cDCs in draining lymph nodes of Flt3L?/? mice in a partially Flt3L‐dependent manner. Thus, Flt3L‐mediated lymphoid tissue DC homeostasis is regulated by steady‐state T cells as well as by proliferative T cells, fostering local development of lymphoid organ resident DCs. 相似文献