全文获取类型
收费全文 | 12722篇 |
免费 | 562篇 |
国内免费 | 93篇 |
专业分类
耳鼻咽喉 | 204篇 |
儿科学 | 152篇 |
妇产科学 | 163篇 |
基础医学 | 1531篇 |
口腔科学 | 177篇 |
临床医学 | 722篇 |
内科学 | 3853篇 |
皮肤病学 | 276篇 |
神经病学 | 942篇 |
特种医学 | 460篇 |
外科学 | 1870篇 |
综合类 | 36篇 |
一般理论 | 3篇 |
预防医学 | 344篇 |
眼科学 | 170篇 |
药学 | 672篇 |
中国医学 | 19篇 |
肿瘤学 | 1783篇 |
出版年
2023年 | 89篇 |
2022年 | 180篇 |
2021年 | 299篇 |
2020年 | 163篇 |
2019年 | 199篇 |
2018年 | 257篇 |
2017年 | 216篇 |
2016年 | 250篇 |
2015年 | 271篇 |
2014年 | 337篇 |
2013年 | 411篇 |
2012年 | 751篇 |
2011年 | 777篇 |
2010年 | 473篇 |
2009年 | 424篇 |
2008年 | 769篇 |
2007年 | 807篇 |
2006年 | 820篇 |
2005年 | 821篇 |
2004年 | 849篇 |
2003年 | 795篇 |
2002年 | 760篇 |
2001年 | 218篇 |
2000年 | 179篇 |
1999年 | 196篇 |
1998年 | 196篇 |
1997年 | 139篇 |
1996年 | 122篇 |
1995年 | 103篇 |
1994年 | 84篇 |
1993年 | 85篇 |
1992年 | 114篇 |
1991年 | 114篇 |
1990年 | 101篇 |
1989年 | 91篇 |
1988年 | 105篇 |
1987年 | 87篇 |
1986年 | 95篇 |
1985年 | 96篇 |
1984年 | 68篇 |
1983年 | 50篇 |
1982年 | 35篇 |
1980年 | 29篇 |
1979年 | 26篇 |
1978年 | 27篇 |
1977年 | 26篇 |
1975年 | 25篇 |
1973年 | 26篇 |
1969年 | 24篇 |
1968年 | 36篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
221.
Normal motor learning during pharmacological prevention of Purkinje cell long-term depression 总被引:11,自引:0,他引:11
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Welsh JP Yamaguchi H Zeng XH Kojo M Nakada Y Takagi A Sugimori M Llinás RR 《Proceedings of the National Academy of Sciences of the United States of America》2005,102(47):17166-17171
Systemic delivery of (1R-1-benzo thiophen-5-yl-2[2-diethylamino)-ethoxy] ethanol hydrochloride (T-588) prevented long-term depression (LTD) of the parallel fiber (PF)-Purkinje cell (PC) synapse induced by conjunctive climbing fiber and PF stimulation in vivo. However, similar concentrations of T-588 in the brains of behaving mice and rats affected neither motor learning in the rotorod test nor the learning of motor timing during classical conditioning of the eyeblink reflex. Rats given doses of T-588 that prevented PF-PC LTD were as proficient as controls in learning to adapt the timing of their conditioned eyeblink response to a 150- or 350-ms change in the timing of the paradigm. The experiment indicates that PF-PC LTD under control of the climbing fibers is not required for general motor adaptation or the learning of response timing in two common models of motor learning for which the cerebellum has been implicated. Alternative mechanisms for motor timing and possible functions for LTD in protection from excitotoxicity are discussed. 相似文献
222.
Masato Maeda MD Dr Masaaki Kanayama MD Yasushi Hasumura MD Jugoro Takeuchi MD Toshikazu Uchida MD 《Digestive diseases and sciences》1988,33(11):1487-1490
Summary A 56-year-old female with mixed connective tissue disease (MCTD) who developed autoimmune hepatitis is described. Hepatitis was controlled effectively by the corticosteroid therapy. Biopsy of the liver revealed swelling and hydropic degeneration of hepatocytes, accompanied by Councilman's body formation and focal necrosis. These histological findings differ from those in three previously described cases. A relationship between MCTD and liver involvement appears possible. 相似文献
223.
224.
Mitsuhashi N Tanaka Y Kubo S Ogawa S Hayashi C Uchino H Shimizu T Watada H Kawasumi M Onuma T Kawamori R 《Endocrine journal》2004,51(6):545-550
The aim of this study was to investigate the effect of cilostazol, a cAMP phosphodiesterase inhibitor, on carotid artery intima-media thickness (IMT) and on the incidence of cardiovascular events in Japanese subjects with type 2 diabetes. A total of 62 type 2 diabetic subjects were allocated equally to the cilostazol treatment group (n = 31) and the control group (n = 31). Carotid IMT was evaluated before and after treatment using B-mode ultrasonography. After the study period (mean +/- SD: 2.6 +/- 0.17 years), carotid IMT showed a significantly greater increase in the control group than in the cilostazol group (0.12 +/- 0.14 mm vs. 0.04 +/- 0.02 mm, p < 0.05). In the control group, 1 out of 31 patients suffered from symptomatic cerebral infarction and 1 had angina pectoris during the observation period. On the other hand, no subject in the cilostazol group developed cardiovascular events during the study period. At baseline, the diabetic patients given cilostazol had a significantly lower HbA1c level than the control subjects, but the other atherosclerotic risk factors (BMI, blood pressure, and serum lipids) and the duration of diabetes did not differ between the two groups. These results indicate that cilostazol therapy can attenuate the increase of carotid artery IMT in Japanese subjects with type 2 diabetes. 相似文献
225.
226.
227.
Takeshi Masaki Makoto Okazawa Ryotaro Asano Tadakatsu Inagaki Tomohiko Ishibashi Akiko Yamagishi Saori Umeki-Mizushima Manami Nishimura Yusuke Manabe Hatsue Ishibashi-Ueda Manabu Shirai Hirotsugu Tsuchimochi James T Pearson Atsushi Kumanogoh Yasushi Sakata Takeshi Ogo Tadamitsu Kishimoto Yoshikazu Nakaoka 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(11)
228.
Kaoru Otsuka Fumio Terasaki Yoshinobu Eishi Hiroaki Shimomura Yasuharu Ogura Taiko Horii Tadashi Isomura Hisayoshi Suma Yasushi Kitaura 《Circulation journal》2007,71(12):1937-1941
BACKGROUND: Cardiac sarcoidosis is frequently overlooked or misdiagnosed as idiopathic dilated cardiomyopathy (DCM), primarily because of difficulties in its diagnosis. This is a crucial issue because appropriate therapy with immunosuppressive agents can be initiated if early diagnosis is achieved. METHODS AND RESULTS: Thoracic computed tomography (CT) was retrospectively analyzed in detail with special reference to lymph node swelling (LNS) in the mediastinum of 8 patients diagnosed with idiopathic DCM who underwent left ventriculoplasty (LVP), and were later proven to have active cardiac sarcoidosis by histological evaluation of the resected myocardium. Twenty age-matched patients with idiopathic DCM who also underwent LVP served as controls. On conventional chest radiographs, none of the cardiac sarcoidosis patients exhibited lymph node involvement, including bilateral hilar lymphadenopathy. However, CT demonstrated significant mediastinal LNS in 7 (88%) of them and in only 1 (5%) of the 20 controls. There was a significant difference in the incidence of LNS in the 2 groups (p=0.00005). CONCLUSION: Evaluation of mediastinal lymphadenopathy by CT is an easy and valuable initial screening method for distinguishing cardiac sarcoidosis from idiopathic DCM. 相似文献
229.
Kuriyama M Kato J Kuwaki K Morimoto N Nawa T Fujimoto T Kono H Okano N Miyaike J Morita T Okada H Suzuki S Yoshioka T Shiode J Suwaki K Sakaguchi K Shiratori Y;Japan West Ulcerative Colitis Study Group 《European journal of gastroenterology & hepatology》2008,20(7):634-641
BACKGROUND AND AIM: The health-related quality of life (HRQOL) of patients with ulcerative colitis (UC) can be impaired because of the chronic symptoms. Although UC patients suffer from such symptoms over the long term, there have been few reports on the changes of HRQOL with disease duration. The aim of this study was to clarify these changes. METHODS: The HRQOL of 331 Japanese UC patients was examined using the validated Japanese version of the Inflammatory Bowel Disease Questionnaire (J-IBDQ). HRQOL and factors affecting HRQOL identified using multiple linear regression analysis were stratified by disease duration. RESULTS: Of the 15 clinical factors examined, the clinical activity index score was the strongest determinant (P<0.0001) of all the scores of IBDQ regardless of disease duration. HRQOL did not differ significantly among patients with different disease durations. The factors, however, that affected HRQOL varied according to disease duration. In patients with disease duration of less than 5 years, the clinical activity index score was the predominant factor affecting HRQOL. Being 'on sick leave or hospitalized' was a significant factor impairing HRQOL in patients with disease duration of 5-9 years. Moreover, complications due to corticosteroids significantly impaired all of the IBDQ scores in patients with disease duration of 10 years or more. CONCLUSION: Factors that affected the HRQOL of UC patients varied according to the patients' disease duration. Our findings should assist in the development of a long-term strategy for the treatment of UC patients. 相似文献
230.
Shiratori Y Kato N Yoshida H Nakata R Ihori M Imazeki F Yokosuka O Kawase T Katamoto T Unuma T Nakamura A Ikegami F Hirota K Omata M 《Digestive diseases and sciences》2000,45(3):565-574
Adequate dosing of interferon (IFN) and its cost-effectiveness for sustained virological response were evaluated in relation to viral load and subtype. Prospective analysis of IFN therapy on 326 patients with chronic hepatitis C free from cirrhosis was performed using 9 or 6 million unit (MU) of IFN for six months daily and/or three times a week. Sustained virological response was achieved in 50–94% of patients with 2 × 104 copies/ml (competitive RT-PCR) or <100 × 103 copies/ml (Amplicor monitor) of HCV RNA by 468–1206 MU of IFN, but response was only 0–25% of the patients with 2 × 105.5 copies/ml (competitive RT-PCR) or >200 × 103 copies/ml (Amplicor monitor), even with 468–1206 MU of IFN. A high sustained rate was demonstrated in patients with 100–200 × 103 copies/ml of HCV RNA by 901–1206 MU of IFN, in comparison to that with 900 MU of IFN. Multivariate analysis showed that IFN dose had a significant value for the efficacy of IFN therapy in patients presenting 100–200 × 103 copies/ml of HCV RNA. Cost efficacy analysis indicated that it cost approximately $10,000, $26,000, and $50,000–227,000 for one person-viral eradication in the patients with <100, 100–200, and >200 × 103 copies/ml, respectively. High-dose IFN is only cost effective in patients with intermediate viral loads, and IFN therapy could be recommended in patients with <200 × 103 copies/ml of HCV RNA. 相似文献