Association between plasma Vitamin B5 levels and all‐cause mortality: A nested case‐control study

We aimed to evaluate the prospective association of vitamin B5 with all‐cause mortality and explore its potential modifiers in Chinese adults with hypertension. A nested, case‐control study was conducted in the China Stroke Primary Prevention Trial, including 505 deaths of all causes and 505 matched controls. The median follow‐up duration was 4.5 years. The primary outcome measure in this investigation was all‐cause mortality, which encompassed deaths for any reason. The mean plasma vitamin B5 concentration for cases (43.7 ng/mL) was higher than that in controls (40.9 ng/mL) (p = .001). When vitamin B5 was further assessed as quintiles, compared with the reference group (Q1: < 33.0 ng/mL), the risk of all‐cause mortality increased by 29% (OR = 1.29, 95% CI: 0.83‐2.01) in Q2, 22% (OR = 1.22, 95% CI: 0.77‐1.94) in Q3, 62% (OR = 1.62, 95% CI: 1.00‐2.62) in Q4, and 77% (OR = 1.77, 95% CI: 1.06‐2.95) in Q5. The trend test was significant (p = .022). When Q4‐Q5 were combined, a significant 41% increment (OR = 1.41, 95% CI: 1.03‐1.95) in all‐cause death risk was found compared with Q1‐Q3. The adverse effects were more pronounced in those with normal folate levels (p‐interaction = .019) and older people (p‐interaction = .037). This study suggests that higher baseline levels of plasma vitamin B5 are a risk factor for all‐cause mortality among Chinese patients with hypertension, especially among older adults and those with adequate folate levels. The findings, if confirmed, may inform novel clinical and nutritional guidelines and interventions to optimize vitamin B5 levels.     

兔高胆固醇-动脉粥样硬化模型心肌血管紧张素Ⅱ的表达及阿托伐他汀的干预效果

目的:建立兔高胆固醇-动脉粥样硬化模型,观察心肌组织血管紧张素Ⅱ(AngⅡ)的表达,探讨阿托伐他汀对心肌组织AngⅡ表达的影响。方法:22只健康雄性新西兰白兔随机分为3组:正常对照组(n=6),高胆固醇饲养组(n=8),高胆固醇饲养加阿托伐他汀(2.5mg&#183;kg-1.d-1)组(n=8)。喂饲8周后,经兔中央动脉取空腹血标本测定血清总胆固醇(TC)及低密度脂蛋白胆固醇(LDL-C)的浓度。取主动脉组织肉眼观察形态学改变;取心肌组织用免疫组化方法测定各组AngⅡ的阳性表达,结果采用阳性单位(PU)表示。结果:高胆固醇饲养组心肌组织AngⅡ的阳性表达显著高于对照组[(21.65&#177;4.20)PU对(4.58&#177;1.20)PU,P&lt;0.05],高胆固醇饲养加阿托伐他汀组AngⅡ的阳性表达(16.50&#177;1.53)PU较高胆固醇饲养组明显降低,但仍显著高于对照组,P&lt;0.05。结论:高胆固醇血症时心肌组织肾素-血管紧张素醛固酮系统(RAAS)处于高度激活状态,阿托伐他汀具有明显的抑制心肌组织RAAS激活的作用。     

细胞周期蛋白G_1参与孕激素对子宫内膜基质细胞增殖作用的研究

目的在体外培养条件下,研究孕激素(P)对子宫内膜基质细胞(ESC)的增殖作用和细胞周期分布的影响及细胞周期蛋白G1(cyclin G1)的表达情况。方法分离小鼠ESC进行原代培养,采用四甲基氨唑蓝法(MTT)检测P处理后ESC的增殖情况,用流式细胞仪检测细胞周期各时相的分布,用细胞免疫化学技术检测cyclin G1蛋白的表达情况。结果孕激素对ESC起增殖作用,在一定范围内呈时间依赖性。孕激素作用12 h后,S期细胞百分数明显上调。雌激素(E)、孕激素(P)、雌激素+孕激素(EP)联合分别刺激ESC 24 h,P组和EP组的ESC增殖,S期的细胞百分数升高,且cyclin G1蛋白表达阳性。E组与空白对照组(C组)的ESC增殖抑制,S期的细胞百分数维持低水平,且cyclin G1蛋白表达阴性。结论孕激素对ESC起增殖作用,引起细胞周期重新分布可能是孕激素促ESC增殖的机制之一。cyclin G1呈孕激素依赖性表达,可能参与孕激素对ESC的促增殖作用。     

皮肤结核一例

患者,女,64岁.颈部斑块结节8年,逐渐增大.患者8年前患乳腺癌,手术切除治疗.曾诊断为毛囊炎、孢子丝菌病、乳腺癌皮肤转移等,给予相应治疗未愈.组织病理学检查:真皮内结核性肉芽肿,结节中央可见干酪样坏死,抗酸染色阳性,PAS染色阴性,真菌培养阴性,PPD(+++).抗结核治疗后皮疹明显消退.     

Colorectal cancer screening for the natural population of Beijing with sequential fecal occult blood test: a multicenter study

Objective To assess the prevalence of colorectal cancer(CRC)in Beijing and the reliability or the sequential fecal occult blood test(SFOBT)for CRC screening.Methods Of the natural population(48 100 persons)in several Beijing communities,we screened 26 827 persone with age over 30 using the SFOBT screening program,Guaiacum Fecal Occult Blood Test(GFOBT),lmmuno Fecal Occult Blood Test(IFOBT),and colonoscopies.Results The screening rate of the population was 74%.The positive rate of SFOBT was 5.6%.The prevalence of CRC in the entire population of Beijing was therefore calculated to be 36.57/10^5.Of 12 CRC detected patients,4 cases were in stage DukesA (33.33%),7 cases in stage Dukes B(58.33%),only 1 case(8.34%)in stage Dukes C.Conclusions The prevalence of CRC in Beijing is one of the highest in China,Individuals at high risk for CRC or those over 50 years of age should be considered as primary candidates for screening,SFOBT screening is a cost-effective and reliable method for early detection of CRC.     

三维能量多普勒超声预测子痫前期的临床应用研究

目的 探讨三维能量多普勒超声（3D-PDU）及其定量参数对预测子痫前期的应用价值。方法 应用三维能量多普勒超声成像对328例11～14周进行常规超声检查的孕妇胎盘血流灌注情况进行前瞻性观察分析,应用三维多普勒直方图计算胎盘血管指数（VI）、血流指数（FI）、血管和血流指数（VFI）。所有患者在16～20周之间再进行一次检查。孕妇随访至分娩结束,按有无发生子痫前期分为正常妊娠组和子痫前期组。结果 16～20周子痫前期组胎盘血管指数（VI）、血流指数（FI）、血管和血流指数（VFI）等胎盘血管指数明显低于对照组。11～14周子痫前期组胎盘血管指数与对照组差异无统计学意义。结论 三维能量多普勒超声可定量分析胎盘血流灌注情况,可以预测及诊断子痫前期。     

罗比卡因与布匹卡因在小儿骶管部麻醉的临床观察

目的探讨0．8％利多卡因加0．25％罗比卡因合剂用于小儿骶管麻醉的临床效果，并与0．8％利多卡因加0．2％布匹卡因合剂进行对照观察。方法选择60例男性小儿骶管麻醉的临床资料进行分析，60例患儿随机分成罗比卡因——利多卡因组（A组）和布匹卡因——利多卡因组（B组）各30例。结果两组患儿麻醉镇痛均完善，但A组患儿的麻醉阻滞完善时间明显短于B组，而麻醉维持时间长于B组p〈0．01；A组患儿术后第一次排尿时间明显短于B组P〈0．01（t=24．305）。结论小儿骶管阻滞适宜于小儿下腹部及会阴部手术，局麻药以0．8％利多卡因加0．25％罗比卡因较佳。     

中西医结合治疗肝硬化腹水疗效观察

[目的]探讨中西医结合方法治疗肝硬化（LC）腹水的疗效。[方法]LC腹水患者62例,对照组28例,采用西医治疗;治疗组34例,西医治疗联合中医药治疗,比较两组患者的腹水消退情况。[结果]治疗组与对照组腹水消退率比较无统计学差异（P〉0.05）;治疗组腹水消退时间明显短于对照组,差异具有统计学意义（P〈0.05）。[结论]中医药在LC腹水的患者治疗中,对腹水的消退疗效显著。     

CIPP多元评价下高职高专内科护理案例教学法的研究

在高职高专内科护理教学中,利用CIPP多元评价体系,研究探讨案例教学法提高教学质量的可行性和效果。     

“一带一路”沿线国家登革热流行情况及变化趋势研究

目的分析2019年"一带一路"沿线国家登革热流行现状及2013-2019年登革热发病率变化趋势。方法利用2019年全球疾病负担研究(GBD)登革热年龄标准化发病率(ASR)数据, 描述2019年"一带一路"区域登革热流行现状, 并计算2013-2019年ASR的年估计百分比变化(EAPC)评估流行趋势。结果 2019年GBD登革热数据显示145个"一带一路"沿线国家中93个(64.14%)国家有登革热流行。2019年登革热发病率>3 000.00/10万的国家共有11个, 9个国家在大洋洲;其次16个国家发病率在1 000.00/10万～2 999.99/10万, 10个国家在亚洲。非洲(58.14%, 25/43)、北美洲(72.73%, 8/11)及南美洲(66.67%, 4/6)等区域的多数国家发病率在500.00/10万～999.99/10万。大洋洲90.00%(9/10)的国家登革热发病率为上升趋势, 斐济上升趋势最明显(EAPC=18.22, 95%CI:12.91～23.77);其次亚洲18.18%(4/22)的国家登革热发病率呈上升趋势, 菲律宾上升趋势最明显(E...