宁夏角叶蚤属一新记录(蚤目,角叶蚤科)

目的发现并记录宁夏跳蚤种类,丰富医学昆虫资源。方法采用媒介生物学调查方法与形态学镜检分类法,将采集的标本常规保存与制片,鉴定蚤种。结果发现角叶蚤属Ceratophyllus Curtis,1832一新记录,即冥河角叶蚤灰沙燕亚种Ceratophyllus styx riparius Jordan et Rothschild,1920。结论宁夏蚤类不断被发现,对预防控制鼠疫等自然疫源性疾病具有重要意义。     

Osteopontin facilitates invasion in human trophoblastic cells via promoting matrix metalloproteinase-9 in vitro

Successful implantation of embryo and placentation depend on proper trophoblast proliferation and differentiated into specialized invasive trophoblast. However, little is known about the regulatory factors and mechanisms in trophoblast proliferation and differentiation. Osteopontin (OPN) is a member of the small integrin-binding ligand N-linked glycoprotein family and participates in cell adhesion and invasion. It has been identified that OPN is highly expressed in invasive trophoblasts in human placenta. In this study, we demonstrated that OPN is constitutively expressed in highly invasive phenotype of human choriocarcinoma cell lines of JAR and JEG-3 cells, and OPN could promote trophoblast proliferation and invasion, partly through promoting MMP-9 secretion. Inhibition of OPN will compromise the abilities of proliferation and invasion in JAR and JEG-3 cell lines. Our data showed that the expression of OPN in trophoblast may participate in placentation, OPN expression defects may be involved in gestational trophoblastic diseases.     

血必净对梗阻肾间质炎性损害的干预实验

目的动态观察单侧输尿管梗阻大鼠（UUO）模型肾间质炎性损害病理改变及核因子-κB（NF～κB）、转化生长因子一β1（TGF-β1）在肾间质的表达,探讨血必净对肾间质炎性损害的干预机制。方法Sprague—Dawley（简称SD）清洁级健康大鼠雌雄各半共60只,随机分为三组：假手术组（SOR组）、模型组（MOD组）、血必净治疗组（XBJ组）。每组20只;建立UUO模型,分别于手术后第7d、第14d各组随机选取10只大鼠,取梗阻侧肾组织,行HE、MASSON染色及免疫组化染色。观察肾脏间质病理变化以及NF—κBp65和TGF一β1在肾间质的表达。结果血必净能减轻UUO大鼠肾间质炎性损害（第7d、第14d肾小管间质损伤指数、肾间质胶原面积P〈0．05）;血必净能下调肾组织间质NF—κBp65及TGF-β1的的表达（P〈0．05）有统计学意义。结论血必净减轻肾间质炎性损害,其机制可能通过抑制肾组织间质NF-κBp65及TGF-β1的的表达,并对早期肾间质纤维化有抑制作用。     

症状性椎基底动脉供血不足老年患者的临床干预研究

目的探讨症状性椎基底动脉供血不足老年患者的支架成形术或（和）药物治疗的可行性、安全性和短期疗效。方法选择我院2001年4月至2006年6月诊治的有后循环缺血症状且经血管造影证实有相关椎基底动脉狭窄（狭窄I〉50％）的老年患者（年龄≥60岁）,所有患者均行内科药物治疗,部分患者还给予椎基底动脉支架成形术治疗,分析其临床、影像学、治疗和随访观察资料。结果共有81例入选本研究,其中男68例,女13例;年龄60～87岁,平均70岁;平均随访28．1个月,81．5％（66／81）的患者临床症状改善或消失;住院及随访期间总卒中发生率为4．9％（4／81）,卒中相关死亡率为2．5％（2／81）。本组中有48例（59．3％）患者行支架成形术治疗,52例次,技术成功率为98．1％,动脉狭窄率由术前（82．4±13．1）％降至（6．4±3．2）％（t=22．4,P=0．00）。结论症状性椎基底动脉狭窄老年患者的支架成形术或（和）内科药物治疗的短期疗效良好。     

成都市6～16岁儿童少年抑郁障碍的流行病学调查

目的:探讨成都市儿童少年抑郁障碍的患病率和共病情况。方法:采用量表填写和访谈同时进行的横断面研究方法。从成都市中小学校中随机抽取了5194名中小学生,应用长处和困难问卷及精神发育和健康状况评定量表对其进行调查。结果:儿童少年抑郁的总体患病率为1.2%。12岁以后女性的抑郁障碍患病率高于男性(2.56%vs.1.42%,P=0.040)。6～8岁、9～11岁、12～14岁和15岁以上年龄组的患病率分别为0.10%、0.51%、1.56%和2.59%。40%的患者至少合并1种其他精神疾病。儿童少年抑郁与焦虑障碍和各种行为障碍共病率分别为29.1%和25.5%。结论:儿童少年抑郁障碍的患病率存在性别和年龄差异。且随着年龄的增加,患病率有上升的趋势。共病在儿童少年抑郁患者中较常见。     

Dietary soy and increased risk of bladder cancer: a prospective cohort study of men in Shanghai, China

To verify our previous finding of a positive association between dietary soy and bladder cancer risk, we examined the association in a second, geographically distinct prospective cohort of Chinese subjects, the Shanghai Cohort Study. Briefly, 18,244 men aged 45-64 years were recruited between January 1986 and September 1989. As of December 31, 2002, 61 incident bladder cancer cases were identified. Information on soy consumption was obtained through in-person interviews at baseline using a food frequency questionnaire. Cox proportional hazard regression methods were used to estimate relative risks (RR) and their corresponding 95% confidence intervals (CI), with adjustment for age (years) at baseline interview, level of education and other potential confounders. Compared to men consuming soy less than once a week, the RR (95% CI) for those who consumed soy 1-<3 times per week, 3-<7 times a week and daily were 2.05 (0.80-5.29), 2.45 (0.89-6.76) and 4.61 (1.57-13.51), respectively (p for trend = 0.004), after adjustment for age, cigarette smoking and level of education. The soy-bladder cancer risk associations in smokers and non-smokers were comparable. The soy-bladder cancer relationship became stronger when the analysis was restricted to subjects with 2 or more years of follow-up.     

农村社区卫生服务对卫生服务公平性的影响

目的研究农村社区卫生服务对卫生服务公平性的影响。方法以现况调查资料作为调查组,既往调查数据为基线组。应用对比研究方法,从健康公平性、卫生服务利用公平性、卫生服务提供公平性3个方面对武陟县农村卫生服务公平性进行评价。结果调查组有关指标均好于基线组。结论农村社区卫生服务在改善健康公平性、卫生服务利用和提供公平性方面起到积极的作用。     

p53,ras,nm23在原发性胃癌中的联合表达研究

应用免疫组化ABC法，检测78例原发性胃癌组织P53、p21（ras基因表达产物）和nm23基因蛋白的表达，探讨其与肿瘤发展、分化程度、淋巴结转移等胄癌生物学行为的关系。结果p53在中晚期胄癌（57％）、低分化胃癌（76％）、伴淋巴结转移胃癌（62％）中的表达明显高于其在早期（1％）、高分化（4％）反不伴淋巴结转移胄癌（20％）中的表达率（P＜0．05）；p21蛋白表达与胃癌分期和有无淋巴结转移的关系也显示了类似趋势，但其与分化程度的关系无统计学意义；nm23表达主要与癌细胞侵袭程度和淋巴结转移呈负相关（P＜0．05），不同分化程度胄癌中的表达无显著差异。结果表明：胃癌的发生、发展可能与多基因异常有关，p53、p21高表达与nm23低表达在癌细胞增殖及肿瘤浸润中起重要作用，胃癌淋巴结转移是一个多基因作用且较为复杂的过程。     

A three-dimensional nanostructure of NiFe(OH)X nanoparticles/nickel foam as an efficient electrocatalyst for urea oxidation

Developing high-performance electrocatalysts for urea oxidation reaction (UOR) can not only solve the problem of environmental pollution, but also solve the problem of the energy crisis by producing hydrogen for electrodes. The preparation of porous three-dimensional nanostructures as efficient electrocatalysts has become important work. Here, we developed a novel three-dimensional (3D) nanostructure of NiFe(OH)_X nanoparticles/nickel foam with a high active area by a simple electroplating method and a subsequent treatment with ferric ion solution. This structure shows much greater UOR activity than the control sample (Ni/Ni foam) with the potential of 1.395 V (vs. RHE) (with an overpotential of 1.025 V) for driving the current density of 100 mA cm⁻² in 1.0 M KOH electrolyte with 0.33 M urea. This work not only provides rapid and large-scale preparation of a three-dimensional nanostructure, but also gives a new way to design and obtain high-performance electrocatalysts.

NiFe(OH)_X nanoparticles/Ni foam as a high-performance UOR electrocatalyst was prepared by a facile and large-scale method.