全文获取类型
收费全文 | 435713篇 |
免费 | 30220篇 |
国内免费 | 6920篇 |
专业分类
耳鼻咽喉 | 5864篇 |
儿科学 | 8948篇 |
妇产科学 | 10701篇 |
基础医学 | 58257篇 |
口腔科学 | 13078篇 |
临床医学 | 37179篇 |
内科学 | 85188篇 |
皮肤病学 | 9048篇 |
神经病学 | 29377篇 |
特种医学 | 16109篇 |
外国民族医学 | 102篇 |
外科学 | 65951篇 |
综合类 | 22691篇 |
现状与发展 | 13篇 |
一般理论 | 66篇 |
预防医学 | 22359篇 |
眼科学 | 10639篇 |
药学 | 37832篇 |
88篇 | |
中国医学 | 6585篇 |
肿瘤学 | 32778篇 |
出版年
2022年 | 3868篇 |
2021年 | 5909篇 |
2020年 | 4200篇 |
2019年 | 4554篇 |
2018年 | 6419篇 |
2017年 | 5353篇 |
2016年 | 5241篇 |
2015年 | 6845篇 |
2014年 | 9098篇 |
2013年 | 10874篇 |
2012年 | 14952篇 |
2011年 | 15317篇 |
2010年 | 10174篇 |
2009年 | 9196篇 |
2008年 | 12998篇 |
2007年 | 13780篇 |
2006年 | 13338篇 |
2005年 | 11823篇 |
2004年 | 10826篇 |
2003年 | 10366篇 |
2002年 | 9790篇 |
2001年 | 29412篇 |
2000年 | 29616篇 |
1999年 | 24184篇 |
1998年 | 5467篇 |
1997年 | 4546篇 |
1996年 | 4046篇 |
1995年 | 3660篇 |
1994年 | 3274篇 |
1993年 | 2941篇 |
1992年 | 16126篇 |
1991年 | 14876篇 |
1990年 | 14234篇 |
1989年 | 14005篇 |
1988年 | 12615篇 |
1987年 | 12086篇 |
1986年 | 11122篇 |
1985年 | 10330篇 |
1984年 | 6920篇 |
1983年 | 5604篇 |
1982年 | 2718篇 |
1979年 | 5477篇 |
1978年 | 3347篇 |
1977年 | 2971篇 |
1975年 | 2641篇 |
1974年 | 3064篇 |
1973年 | 2865篇 |
1972年 | 2828篇 |
1971年 | 2773篇 |
1969年 | 2543篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
目的:直肠腺瘤和其他疑似为良性的病变应用经肛门内镜切除术并未普及。该项研究旨在评估经肛门内镜切除术的效能和安全性。方法:回顾性研究分析在1993-2004年之间3所斯德哥尔摩医院中经肛门内镜切除术的患,内容包括患自身及病变特性、并发症、随访时间和复发率。结果:180例中共131例行经肛门内镜切除术。160例经组织学诊断为腺瘤,12例为癌瘤,其余8例分别为增生、纤维化或正常黏膜。直肠腺瘤患中,77例仅行单次经肛门内镜切除术,16例因巨大腺瘤而多次行该手术,27例因复发而需另行经肛门内镜切除术或其他手术。中位复发时间为7个月,但未出现直肠癌。16例手术患出现并发症。2例患必须行Hartman手术,1例因肠穿孔,另1例因出血。手术期间无死亡。未复发的中位随访期为32个月(极差0—67)。[编按] 相似文献
62.
L Laforest E Van Ganse G Devouassoux S Chretin L Osman G Bauguil Y Pacheco G Chamba 《The European respiratory journal》2006,27(1):42-50
French asthma patients may be supervised by general practitioners (GPs) and/or specialists. Therefore, this study examined asthma management in patients exclusively supervised by specialists (SPE), GPs, (GP) and both (GP+SPE group), and compared the findings. Asthma patients were consecutively recruited in 348 pharmacies. Each patient completed a questionnaire providing data on personal characteristics, asthma management, perception of disease and asthma supervision. Asthma control was measured using the Asthma Control Test. Questionnaires were linked to computerised records of medications which had been dispensed before inclusion in the study. From the 1,256 patients (mean age = 36.1 yrs, 54.3% females), 11.4, 36.6, and 52.0% were placed in the SPE, GP, and GP+SPE groups, respectively. During the previous 4 weeks, most patients in the SPE group were properly controlled (52.2 versus 26.4 and 21.5% in GP and GP+SPE groups, respectively). The SPE group made more use of fixed combinations of long-acting beta agonist and inhaled corticosteroid, while receiving less short-acting beta agonists, antitussives and antibiotics. Striking differences in symptoms and asthma management were observed according to the type of asthma supervision. The current results strongly support the need to improve the management of asthma in primary care, and the coordination of care between general practitioners and specialists. 相似文献
63.
64.
65.
H Ishihara M Bjeljac D Straumann Y Kaku P Roth Y Yonekawa 《Minimally invasive neurosurgery》2006,49(3):168-172
OBJECTIVE: A safe entry zone to tegmental lesions was identified based on intraoperative electrophysiological findings, the compound muscle action potentials (CMAP) from the extraocular muscles, and anatomic considerations. This entry zone is bordered caudally by the intramesencephalic path of the trochlear, laterally by the spinothalamic tract, and rostrally by the caudal margin of the brachium of the superior colliculus. METHODS: Four intrinsic midbrain lesions were operated upon via the safe entry zone using the infratentorial paramedian supracerebellar approach. All lesions involved the tegmentum and included an anaplastic astrocytoma, a metastatic brain tumor, a radiation necrosis, and a cavernous angioma. CMAP were bilaterally monitored from the inferior recti (for oculomotor function) and superior oblique (for trochlear nerve function) muscles. RESULTS: In three of four cases, CMAP related to the oculomotor nerve were obtained upon stimulation at the cavity wall after removal of the tumor. Stimulation at the surface of the quadrigeminal plate, however, did not cause any CMAP response. Using this monitoring as an indicator, the lesions were totally removed. CONCLUSIONS: In the surgery of tegmental lesions, CMAP monitoring from extraocular muscles is particularly helpful to prevent damage to crucial neural structures during removal of intrinsic lesions, but less so to select the site of the medullary incision. The approach via the lateral part of the colliculi is considered to be a safe route to approach the tegmental lesions. 相似文献
66.
Y Ohtsuka X-T Wang J Saito T Ishida M Munakata 《The European respiratory journal》2006,28(5):1013-1019
Inter-individual variations in the development of silicosis, even within the same environments, have been reported, which suggest the contribution of genetic factors in silicosis aetiology. The aim of the present study was to determine whether there is any significant genetic influence on the development of silicosis. Furthermore, which genetic loci are responsible for the pulmonary response to silica exposure? Eight strains of inbred mice were used to examine the genetic influence on the lung fibrotic response to silica exposure. After intercross-breeding between the most susceptible and most resistant strains, a genome-wide linkage analysis of quantitative trait loci (QTL) was performed. Hydroxyproline was applied as an index, and genotypes of 167 marker genes were analysed by fragment analysis using a capillary-type sequencer. There was significant inter-strain difference in the mean concentration of hydroxyproline contents among the eight strains of mice. Breeding studies were conducted between the most susceptible, C57BL/6J, and the most resistant strain, CBA/J. A genome-wide linkage analysis of silica-exposed intercrossed cohorts identified significant QTL on chromosome 4 and suggestive QTL on chromosomes 3 and 18. The present study demonstrates that genetic factors may play a significant role in fibrotic-lung responses to silica; one significant and two suggestive quantitative trait loci were identified. 相似文献
67.
AIMS: To establish all-cause and cause-specific death rates, and risk factors for mortality in insulin-treated diabetic individuals living in the province of Canterbury, New Zealand. METHODS: Insulin-treated diabetic subjects (n = 995) on the Canterbury Diabetes Registry were followed up over 15 years and vital status determined. Death rates were standardized and hazard regression was used to model the effects of demographic covariates on relative survival time. RESULTS: There were 419 deaths in 11 226.3 person-years of follow-up with a standardized mortality ratio (SMR) of 2.0 (95% confidence interval (CI) 1.8-2.2). Relative mortality was greatest for the group aged 0-29 years (SMR 3.0 (95% CI 2.4-3.7)). After controlling for diabetes duration and gender, a 10-year increment in age of onset was associated with a 33% decrease in relative hazard (95% CI 29-36%), indicating that excess mortality due to diabetes declines with rising age of onset. After controlling for age of onset and gender, each 10-year increment in duration of diabetes is associated with a 26% decrease in relative hazard (95% CI 24-29%), indicating that with longer survival the mortality hazard approaches the general population hazard. Relative mortalities were increased for cardiovascular, renal and respiratory disease, but not malignancy. Relative mortality from acute metabolic complications was increased in the subgroup with age of onset of diabetes < 30 years and requiring insulin within 1 year of diagnosis. CONCLUSIONS: Mortality rates are high for insulin-treated diabetic individuals relative to the general population. 相似文献
68.
69.
To examine the prevalence of Internet sex networking among men who have sex with men (MSM) in Hong Kong and risk behaviors associated with the behavior, a telephone survey of 15,230 Hong Kong Chinese men aged 18-60 was conducted. Of the 283 active MSM (having engaged in some MSM behaviors in the last 6 months) identified, 17.7% had networked for MSM partners via the Internet in the last 6 months. Younger age (odds ratio [OR] for age < or = 25 vs. age >25 = 4.67, 95% confidence interval [CI] = 2.35-9.28) and being an anal-sex MSM (OR = 4.72, 95% CI=2.36-9.44) were independent predictors of Internet sex networking. Being an Internet sex networker was associated with some risk behaviors such as having contracted a sexually transmitted disease (adjusted OR = 4.79, 95% CI = 1.34-17.11), having had > or = 3 MSM partners (adjusted OR = 4.74, 95% CI = 2.20-10.23), and having engaged in anal sex (adjusted OR = 3.95, 95% CI = 1.89-8.23). HIV prevention programs for MSM should thereby include Internet-based interventions. 相似文献
70.