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161.
Anaesthetic management for caesarean section in a case of peripartum cardiomyopathy is reported. Various anaesthetic problems in such a case are discussed.KEY WORDS: General anaesthesia, Peripartum cardiomyopathy, Lower segment caesarean section 相似文献
162.
Colonial and other unsustainable oral health strategies exported to Africa have failed to improve oral health in the region. An alternative way of interpreting and responding to the problems of oral health in Africa is presented. It begins with a systematic interpretation of the health information available, using the application of the basic epidemiological principle of defining a specific health problem by describing its prevalence, severity (morbidity, mortality) and age adjusted distribution in the population. African oral disease priorities determined in this way are shown to be fundamentally different from those perceived previously. It is recommended that this new approach be used in customising a viable set of oral health policies and intervention strategies for each individual African community. 相似文献
163.
Alterations in the phenotype of hairy cells during culture in the presence of PHA: requirement for T cells 总被引:2,自引:1,他引:1
Culture studies of peripheral blood mononuclear cells from 7 entirely typical cases of hairy cell leukemia showed that after culture in the presence of PHA for 2--5 days, the predominant cell type changed from E- SIg+ CIg+ gamma FcR+ muFcR+ hairy cells to an E+ SIg- CIg- gamma FcR- muFcR- population of transformed cells derived from hairy cells. Depletion and readdition experiments demonstrated that cell-to-cell contact with T cells was necessary for the phenotypic change, while several observations indicated that the E+ population was not derived from T cells present before culture. The E positivity of the cultured cells was shown to be due to the possession of E receptor not acquired from the culture fluid, but the cells differed from true T cells in lacking both mature and immature T-cell antigens. The relevance of these in vitro observations to the continuing controversy concerning the nature of the hairy cell and to the in vivo fluctuations in immunologic phenotype not infrequently observed in hairy cell leukemia is briefly discussed. 相似文献
164.
165.
Assessment of the proliferative,apoptotic and cellular renovation indices of the human mammary epithelium during the follicular and luteal phases of the menstrual cycle 总被引:1,自引:0,他引:1 下载免费PDF全文
Navarrete MA Maier CM Falzoni R Quadros LG Lima GR Baracat EC Nazário AC 《Breast cancer research : BCR》2005,7(3):R306-R313
Introduction
During the menstrual cycle, the mammary gland goes through sequential waves of proliferation and apoptosis. In mammary epithelial cells, hormonal and non-hormonal factors regulate apoptosis. To determine the cyclical effects of gonadal steroids on breast homeostasis, we evaluated the apoptotic index (AI) determined by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining in human mammary epithelial cells during the spontaneous menstrual cycle and correlated it with cellular proliferation as determined by the expression of Ki-67 during the same period. 相似文献166.
Pregnancy with concomitant chorangioma and placental vascular malformation with mesenchymal hyperplasia 总被引:2,自引:1,他引:2
Chen CP; Chern SR; Wang TY; Huang ZD; Huang MC; Chuang CY 《Human reproduction (Oxford, England)》1997,12(11):2553-2556
We present two pregnancies associated with normal live births and the
unusual concomitance of chorangioma and placental vascular malformation
with mesenchymal hyperplasia. The enlarged placenta had the characteristic
findings of chorangioma, dilated and varicose chorionic vessels and
multiple vesicle-like villi containing hyaluronic acid. The vesicle-like
villi showed diploid cellular DNA contents. Molecular genetic analysis
using the polymerase chain reaction amplification of polymorphic
microsatellite markers confirmed genetic identity among the chorangioma,
the vesicle-like villi and the fetus. Both pregnancies were complicated by
polyhydramnios, pre-term labour and prematurity. One neonate suffered from
anaemia and thrombocytopenia. Another neonate suffered from
haemangiomatosis. Our cases demonstrate that concomitant chorangioma and
placental mesenchymal hyperplasia are genetically identical to the fetus
and can coexist with a normal viable fetus. Since haemangiomas,
chorangiomas, chorionic vessels and villi mesenchymal cells are all derived
from the mesoderm, a combination of fetal haemangiomas, placental vascular
malformation, chorangiomas and placental mesenchymal hyperplasia may
represent a mixed form of congenital malformation of the mesoderm.
相似文献
167.
Medroxyprogesterone acetate with Zoladex for long-term treatment of fibroids: effects on bone density and patient acceptability 总被引:1,自引:0,他引:1
Caird LE; West CP; Lumsden MA; Hannan WJ; Gow SM 《Human reproduction (Oxford, England)》1997,12(3):436-440
A randomized trial was carried out to investigate the effect of 12 months
administration of the gonadotrophin-releasing hormone agonist (GnRHa)
Zoladex in combination with either placebo or medroxyprogesterone acetate
(MPA) from the third month. Bone density, markers of bone resorption,
symptoms and uterine volume were monitored in 24 women with symptomatic
fibroids or menstrual problems. A total of 21 women were recruited to act
as controls for the assessment of bone parameters. Vasomotor side-effects
were reduced significantly in the MPA-treated group. The reduction in
uterine volume in women with fibroids was not impaired by the addition of
MPA. The bone markers osteocalcin and alkaline phosphatase were assessed in
plasma, and the cross-links pyridinoline and deoxypyridinoline measured in
urine. Changes in these markers are reported which suggest increases in
bone resorption during the period of observation. Bone mineral density
(BMD) was assessed by dual energy X-ray absorptiometry at the spine and
forearm. The net reduction in BMD at the spine in the treated groups was
4.30 +/- 0.59% at 6 months and 7.50 +/- 0.78% at 1 year, with no change in
the control group. No change was seen in forearm BMD. No protective effect
was observed when MPA was added. At 1 year after the completion of
treatment, BMD remained significantly below baseline, and this has
implications for the prolonged use of GnRHa.
相似文献
168.
ES Petherick S O'Meara K Spilsbury CP Iglesias EA Nelson DJ Torgerson 《BMC medical research methodology》2006,6(1):43-4
Background
A trial was commissioned to evaluate the effectiveness of larval therapy to debride and heal sloughy and necrotic venous leg ulcers. Larval therapy in the trial was to be delivered in either loose or bagged form. Researchers were concerned that resistance to larval therapy may threaten the feasibility of the trial. Additionally there was concern that the use of larval therapy may require a larger effect size in time to healing than originally proposed by the investigators. 相似文献169.
Talbot K; Ponting CP; Theodosiou AM; Rodrigues NR; Surtees R; Mountford R; Davies KE 《Human molecular genetics》1997,6(3):497-500
The Survival Motor Neuron (SMN) gene shows deletions in the majority of
patients with Spinal Muscular Atrophy (SMA), a disease of motor neuron
degeneration. To date only two missense mutations have been reported in SMN
in patients with SMA. The fact that no SMN-homologues have been forthcoming
from data-base searching has resulted in a lack of hypotheses concerning
the structural and functional consequences of these mutations. Recently SMN
has been shown to interact with heterogeneous nuclear ribonucleoproteins
(hnRNPs) suggesting a role in mRNA metabolism. We describe a novel missense
mutation and the subsequent identification of a triplicated
tyrosine-glycine (Y-G) peptide sequence at the C-terminal of SMN which
encompasses each of the three predicted amino acid sequence substitutions.
We have identified apparent orthologues of SMN in Caenorhabditis elegans
and Schizosaccharomyces pombe. These sequences retain the highly conserved
Y-G motif and provide additional support for a role of SMN in mRNA
metabolism.
相似文献
170.