全文获取类型
收费全文 | 584064篇 |
免费 | 85251篇 |
国内免费 | 34849篇 |
专业分类
耳鼻咽喉 | 5777篇 |
儿科学 | 10782篇 |
妇产科学 | 5755篇 |
基础医学 | 66947篇 |
口腔科学 | 13443篇 |
临床医学 | 81097篇 |
内科学 | 87571篇 |
皮肤病学 | 12797篇 |
神经病学 | 35064篇 |
特种医学 | 21100篇 |
外国民族医学 | 263篇 |
外科学 | 59712篇 |
综合类 | 102459篇 |
现状与发展 | 123篇 |
一般理论 | 61篇 |
预防医学 | 44258篇 |
眼科学 | 14712篇 |
药学 | 60438篇 |
591篇 | |
中国医学 | 36618篇 |
肿瘤学 | 44596篇 |
出版年
2024年 | 1796篇 |
2023年 | 7208篇 |
2022年 | 18949篇 |
2021年 | 25262篇 |
2020年 | 23684篇 |
2019年 | 24807篇 |
2018年 | 25279篇 |
2017年 | 26372篇 |
2016年 | 25647篇 |
2015年 | 33779篇 |
2014年 | 39465篇 |
2013年 | 38642篇 |
2012年 | 43836篇 |
2011年 | 48281篇 |
2010年 | 39798篇 |
2009年 | 30831篇 |
2008年 | 32500篇 |
2007年 | 31131篇 |
2006年 | 29590篇 |
2005年 | 26981篇 |
2004年 | 18677篇 |
2003年 | 18068篇 |
2002年 | 15112篇 |
2001年 | 12767篇 |
2000年 | 11546篇 |
1999年 | 10464篇 |
1998年 | 6321篇 |
1997年 | 6055篇 |
1996年 | 4705篇 |
1995年 | 4397篇 |
1994年 | 3633篇 |
1993年 | 2359篇 |
1992年 | 2804篇 |
1991年 | 2415篇 |
1990年 | 2067篇 |
1989年 | 1769篇 |
1988年 | 1466篇 |
1987年 | 1363篇 |
1986年 | 1106篇 |
1985年 | 791篇 |
1984年 | 439篇 |
1983年 | 319篇 |
1982年 | 183篇 |
1981年 | 213篇 |
1980年 | 144篇 |
1979年 | 222篇 |
1978年 | 105篇 |
1977年 | 84篇 |
1974年 | 95篇 |
1973年 | 76篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
21.
22.
23.
The Transient Receptor Potential Vanilloid 1 Antagonist Capsazepine Improves the Impaired Lung Mechanics during Endotoxemia 下载免费PDF全文
Layla D. M. Cabral Alexandre Giusti‐Paiva 《Basic & clinical pharmacology & toxicology》2016,119(5):421-427
Acute lung injury (ALI) caused by systemic inflammatory response remains a leading cause of morbidity and mortality in critically ill patients. Management of patients with sepsis is largely limited to supportive therapies, reflecting an incomplete understanding of the underlying pathophysiology. Furthermore, there have been limited advances in the treatments for ALI. In this study, lung function and a histological analysis were performed to evaluate the impact of transient receptor potential vanilloid‐1 receptor (TRPV1) antagonist (capsazepine; CPZ) on the lipopolysaccharide (LPS)‐induced lung injury in mice. For this, adult mice pre‐treated with CPZ or vehicle received intraperitoneal injections of LPS or saline and 24 hr after, the mice were anaesthetized, and lung mechanics was evaluated. The LPS‐challenged mice exhibited substantial mechanical impairment, characterized by increases in respiratory system resistance, respiratory system elastance, tissue damping and tissue elastance. The pre‐treatment with CPZ prevented the increase in respiratory system resistance and decreased the increase in tissue damping during endotoxemia. In addition, mice pre‐treated with CPZ had an attenuated lung injury evidenced by reduction on collapsed area of the lung parenchyma induced by LPS. This suggests that the TRPV1 antagonist capsazepine has a protective effect on lung mechanics in ALI during endotoxemia and that it may be a target for enhanced therapeutic efficacy in ALI. 相似文献
24.
25.
Based on the physical randomization of completely randomized experiments, in a recent article in Statistics in Medicine, Rigdon and Hudgens propose two approaches to obtaining exact confidence intervals for the average causal effect on a binary outcome. They construct the first confidence interval by combining, with the Bonferroni adjustment, the prediction sets for treatment effects among treatment and control groups, and the second one by inverting a series of randomization tests. With sample size n, their second approach requires performing O(n4)randomization tests. We demonstrate that the physical randomization also justifies other ways to constructing exact confidence intervals that are more computationally efficient. By exploiting recent advances in hypergeometric confidence intervals and the stochastic order information of randomization tests, we propose approaches that either do not need to invoke Monte Carlo or require performing at most O(n2)randomization tests. We provide technical details and R code in the Supporting Information . Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
26.
27.
Xiujuan Tian Zhiying Chen Shaomin Shi Xianwen Wang Wanli Wang Ning Li Jing Wang 《Medicine》2015,94(37)
Oral cancer, predominantly oral squamous cell carcinoma (OSCC), is one of the most leading causes of cancers worldwide. Due to a low 5-year survival rate, highly effective methods for the early detection of OSCC are totally needed. MicroRNAs (miRNAs), as promising biomarkers, can bring insights into tumorigenesis of oral cancers. However, studies on the accuracy of miRNAs detection in OSCC have inconsistent conclusions, leading us to conduct this meta-analysis. The aim of this study was to systematically review the articles investigating the diagnostic value of miRNAs in OSCC.The PubMed, Embase, Chinese National Knowledge Infrastructure (CNKI), Web of Science were searched (updated to June 11th, 2015) to identify all articles evaluating the diagnostic yield of miRNAs for OSCC. The pooled sensitivity, specificity, and other diagnostic parameters were used to assess the performance of miRNAs assays on OSCC detection. Statistical analysis was conducted by employing the R software.The present meta-analysis comprised 23 studies from 10 articles, including 598 OSCC patients and 320 healthy individuals, available for analysis. The summary receiver operator characteristic (SROC) curve was plotted. Meanwhile, the pooled diagnostic parameters and the area under curve (AUC) were calculated based on all included studies. The pooled diagnostic parameters calculated from all 23 studies were as follows: pooled sensitivity of 0.759 (95% CI: 0.701–0.809), pooled specificity of 0.773 (95% CI: 0.713–0.823) and AUC of 0.832, which indicates a relatively high diagnostic accuracy of miRNAs in differentiating OSCC patients from healthy controls. Meanwhile, In addition, subgroup analyses were conducted to access the heterogeneity between studies, which is based on specimen (serum/plasma/blood/saliva/ tissue) and ethnicity (Asian/Caucasian).In summary, our meta-analysis suggests that miRNAs might be used in noninvasive screening tests for OSCC, which needs further large-scale studies to be validated. 相似文献
28.
29.
30.
A mixed‐method study of effects of a therapeutic play intervention for children on parental anxiety and parents' perceptions of the intervention 下载免费PDF全文