五倍南星膏外敷治疗颌下淋巴结炎26例

自1998年2月-2004年12月共应用五倍南星膏治疗颌下淋巴结炎病人26例，收到良好的临床效果，现报告如下：     

中医治疗胆汁反流性胃炎的研究近况

近年来由于胃镜的普及,胆汁反流性胃炎的检出率大大增加,该病逐渐受到人们的重视,已成为消化系的常见多发病。西医目前尚无特效药物治疗。中医药治疗本病无论基础方加减,还是辨证论治,均取得较好疗效,具有一定优势。现对近2年来中医药治疗胆汁反流性胃炎的进展作一综述。     

肝细胞癌合并胆管癌栓患者术中癌栓的处理

目的 探讨肝细胞癌（HCC）合并胆管癌栓患者术中癌栓的处理方式和术后恢复过程。方法 对1995年1月-2002年12月手术治疗的27例HCC合并胆管癌栓情况进行回顾性总结和分析。结果 只有59．3％（16／27）患者行肝切除、胆管取癌栓及胆管引流术。全组术后并发症发生率为55．6％（15／27），术后30d病死率为22．2％（6／27）。结论 HCC合并胆管癌栓的预后差，早期诊断和外科手术治疗是改善此病预后的关键。     

T-2 toxin induces apoptosis, and selenium partly blocks, T-2 toxin induced apoptosis in chondrocytes through modulation of the Bax/Bcl-2 ratio.

T-2 toxin is one of the mycotoxins, a group of type A trichothecenes produced by several fungal genera including Fusarium species. In the present study, we have investigated the apoptotic effects of T-2 toxin on chondrocytes and the relationship between T-2 toxin induced chondrocyte apoptosis and its influence on Bcl-2/Bax protein and mRNA expression. We have also examined the inhibitory effects of selenium on chondrocyte apoptosis induced by T-2 toxin. We have combined morphological and biological techniques to establish the relevance of apoptosis in human chondrocyte death induced by T-2 toxin. Treatment with T-2 toxin caused accelerated apoptosis in a concentration dependent manner. The apoptosis induced by T-2 toxin involved an increased Bax/Bcl-2 ratio. Bcl-2 mRNA expression remained unchanged in chondrocyte apoptosis induced by T-2 toxin treatment, while Bax mRNA expression increased following treatment with T-2 toxin. Selenium could partly block the apoptosis of chondrocytes induced by T-2 toxin through decreasing the Bax/Bcl-2 ratio. These results suggest that, under our experimental conditions, apoptosis of chondrocytes can be induced by T-2 toxin (1-20ng/mL) via the Bcl-2 and Bax proteins, and the Bax/Bcl-2 ratio may play a critical role in governing the susceptibility to apoptosis induced by T-2 toxin in human chondrocytes.     

Kindergarten children's representation and understanding of written number symbols

Two samples of kindergarten children's representation and understanding of written number symbols were examined in two time points in one academic year. About 85% of Chinese five year olds (mean = 5 years 10 months) were able to use conventional number symbols to represent the quantity of 30 or larger. At the end of the kindergarten year, 94% of Chinese six year olds (mean = 6 years 4 months) were able to use conventional number symbols to represent the quantity of 100 or larger. Some Chinese six year olds had problems in representing written addition and subtraction tasks. Children's ability to represent written number symbols, ability to represent written addition and subtraction formula and their performance on written addition and subtraction were closely related. The performance of children in a university-affiliated childcare center was better than that of the center serving working-class families in Time 1, but the performance reversed at the end of the kindergarten year.     

分步延期切开复位内固定治疗胫骨Pilon骨折29例

目的 :介绍采用分步延期切开复位内固定治疗 Pilon骨折的经验 ,并进行评估。方法 :采用分步延期切开复位内固定治疗 2 9例 Pilon骨折 ,先用跨踝关节外固定支架临时固定 ,若同时有腓骨骨折一期行切开复位内固定腓骨 ,软组织肿胀消退后 ,再行切开复位内固定胫骨 ,采用影像学与 Helfet标准来评定疗效。结果 :术后 2 5例获得优良关节面复位 ( 86.2 % ) ,2 6例下肢力线恢复良好 ( 89.7% ) ,所有病例均获得随访 ,随访时间 1 2～ 40个月。采用Helfet标准评定疗效 :优 9例 ( 31 % ) ,良 1 3例 ( 4 4.8% ) ,差 7例 ( 2 4 .1 % ) ;优良率 75 .9% ;切口感染 3例 ,切口边缘皮肤坏死 1例 ,通过换药创口愈合 ;关节退行性变 1 1例 ;关节强直 1例。结论 :采用分步延期切开复位内固定治疗胫骨 Pilon骨折能有效降低并发症的发生率 ,获得良好的踝关节功能 ,是治疗胫骨 Pilon骨折一种有效的方法。     

CD44v7/8基因表达与宫颈癌关系的探讨

目的探讨宫颈癌组织中CD44v7/8基因的异常表达及临床意义。方法1986～2000年沈阳医学院附属中心医院采用免疫组化的方法随机测定59例宫颈癌、18例尖锐湿疣和18例慢性宫颈炎组织中CD44v7/8基因的表达情况。结果宫颈癌、尖锐湿疣及慢性宫颈炎3种疾病中CD44v7/8表达阳性率分别为76.27%、11.11%和11.11%,宫颈癌组的CD44v7/8表达分别高于慢性宫颈炎组及尖锐湿疣组,且差异非常显著(P<0.01)。慢性宫颈炎组及尖锐湿疣组比较差异无显著性(P>0.05)。结论CD44v7/8蛋白的表达增强与宫颈癌的发生、发展及和局部浸润转移有关。