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951.
作者以ABEI-CoCl_2-H_2O_2作为化学发光指示系统,用固相竞争法检测58例白细胞减少症患者、41例无白细胞减少症患者及32例正常人等的粒细胞抗体IgG。判断标准采用正常人血清化学发光强度指数法。实验结果表明,白细胞减少症患者血清中粒细胞抗体阳性率明显高于无白细胞减少症患者(P<0.005)。本法敏感性为43.1%,特异性为90.2%,准确性为62.6%,是一种灵敏而准确的方法,能将粒细胞包被试管在室温下较长时间保存,以供临床监测粒细胞抗体,大大缩短检测时间。 相似文献
952.
1986~1992年我院共收治急性发作期慢性肺心病196例,其中因严重肺部感染发生多器官衰竭(MOF)者70例(35.7%),平均受损脏器2.5个,死亡26例,总病死率为37.1%。其中2和3个脏器受损者的病死率分别为20.1%和44.4%,而4和5个脏器受损者则均死亡。血气分析显示pH和PaO2值与受损脏器数目呈负相关,而PaCO2值与受损脏器数目呈正相关。本文讨论了肺心病因肺部感染并发MOF的发病机理,并提出防治的措施。 相似文献
953.
To evaluate the effect of interleukin-8 (IL8) on glomerular basement membrane (GBM) sulfated compounds and albuminuria, we
infused IL8 in 1% bovine serum albumin (BSA) for 5 days into the left renal artery of Holtzman male rats at the rate of 10
μl/h using an osmotic pump. Control rats received 1% BSA. A significant increase in urinary albumin/creatinine ratio was seen
on the last day of IL8 infusion (0.38±0.11, mean ± SEM) when compared with albumin/creatinine ratio prior to infusion (0.19±0.04,
P = 0.04). No significant differences in urinary albumin excretion prior to and after infusion of 1% BSA were observed. On
the last day of infusion, rats were injected with 35sulfate (1.0 mCi/200 g body weight) intraperitoneally and killed after 8 h. Glomeruli were isolated and GBM obtained. After
5 days of IL8 administration, there was a significant increase in 35sulfate uptake by GBM of the infused kidney (76±10 cpm/dry glomerular weight, mean ± SEM) compared with the uptake seen in
the contralateral kidney (53±9, P = 0.05). The in vivo infusion of IL8 increased the 35sulfate uptake by GBM and augmented the urinary albumin/creatinine ratio, suggesting that IL8 may induce albuminuria by altering
the metabolism of the GBM sulfated compounds. This hypothesis needs to be confirmed by studies on glomerular charge selectivity
and GBM anionic sites during the course of the infusion. Moreover, the persistence of the effect needs to be evaluated by
prolonging the infusion for more than 5 days.
Received June 3, 1996; received in revised form and accepted October 18, 1996 相似文献
954.
本文动用自制t-PA单克隆抗体建立t-PA:Aa夹心ELISA法。结合t-PA:A、PAI:A测定,对50例正常人,87例肝病,47例冠心病和19例深静脉血栓 成患者的血浆t-PA:Ag、t-PA:A、PAI:A水平进行了研究。 相似文献
955.
全身(全淋巴)照射后100例医源性急性放射病的临床分析 总被引:1,自引:1,他引:0
在造血干细胞移植治疗肿瘤过程中用全身照射(TBI)或全淋巴照射(TLI)预处理,研究受照不同剂量患者发生医源性急性放射病严重程度,治疗方法和造血恢复及相关合并症。方法100例患者(白血病91例,其他肿瘤9例)接受500~1000cGyTBI或TLI和超大剂量化疗作预处理。结果均发生医源性急性放射病,白细胞降至(0~0.15)×109/L,骨髓空虚,合并各种感染和出血。经造血干细胞移植,抗感染,应用GM-CSF或G-CSF积极支持治疗及保护隔离措施,92例造血恢复,8例死于不同感染和出血。结论造血干细胞的移植起主要治疗作用,不同造血因子用于治疗急性放射病,可能是一种有希望的方法 相似文献
956.
Good regulation of acupuncture in simple obesity patients with stomach-intestine excessive heat type 下载免费PDF全文
In order to investigate the regulatory effect of acupuncture on obesity patients with the Stomach-Intestine Excessive Heat Type, the pre-acupunctureal and post-acupunctural obesity index and biochemical indices of 718 simple obesity patients with Stomach-Intestine Excessive Heat Type were observed. It was showed that the marked weight loss effect was achieved in the cases by acupuncture, and the biochemical indices improved. It suggests that acupuncture had a optimal regulatory effect on the function of nerve, endocrine, digestion and energy metabolism. 相似文献
957.
本实验将大鼠从上海空运至兰州,很快转至高海拔地区,用光镜及电镜观察了亚硒酸钠对大鼠的影响。结果发现在高原环境下大鼠对硒的耐受力减低,引起了大鼠猝死半加得高原缺氧对心肌的损伤,降低了大鼠高原适应性。本文还对其耐受机理进行了初步讨论。 相似文献
958.
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960.
David M. Kelley Alan Lichtenstein Jianyi Wang Anna N. Taylor Steven M. Dubinett 《Immunopharmacology and immunotoxicology》1994,16(2):139-148
Previous studies have suggested that corticotropin-releasing factor (CRF) has immunoregulatory effects in addition to its neuroendocrine role. We examined the ability of CRF to inhibit lipopolysaccharide (LPS)-induced pulmonary vascular leak in vivo. Female BALB/C mice were treated with either normal saline (NS) or CRF prior to injection with LPS. Pulmonary vascular leak was inhibited by CRF as assessed by measurement of lung wet-to-dry ratios. The stress-induced increase in serum corticosterone levels in mice injected with LPS alone was not further increased by treatment with CRF. This indicates that the effect of CRF was not mediated centrally by stimulation of endogenous steroid release. Histologic examination of the lungs revealed that leukocyte infiltration was significantly depressed in CRF-treated mice thus confirming the protective effect of CRF. In addition, a modest prolongation of survival was demonstrated in CRF-treated mice following challenge with LPS (p=.08). These data indicate the potential utility of CRF as a modulator of pulmonary vascular leak. 相似文献