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61.
探讨人的增强子结合蛋白(C/EBP)相关基因。方法以大鼠C/EBPcDNA为探针,筛选人胎盘cDNA文库。结果得到一个含有1975碱基命名为HP8的cDNA克隆,其中1~604位碱基属编码区。经基因数据库查对未发现同源基因。该基因编码的蛋白C-末端含有亮氨酸拉链结构(leucine zipper struceure)和C/EBP功能区(C-末端60个氨基酸)同源性高达97%,而上游编码区则与C/EBP及其已知家族同源性很低,表明该基因属C/EBP基因家族新成员。基因组Southern杂交证实该基因为单拷贝基因。在14种胎儿组织中显示小肠、皮肤高表达,肾上腺中度表达,肝、肺、肾、甲状腺、胆囊低表达。在3例正常成人肝组织中仅1例低表达,而在5对肝癌及癌旁肝组织中显示2例癌组织及1例癌旁组织高表达。结论以上结果提示该基因可能与细胞增殖有关。 相似文献
62.
63.
复方环丙氟哌酸鼻腔膜的研制及临床疗效观察 总被引:1,自引:1,他引:0
本文以明胶海绵为衬底,用环丙氟哌酸和氢化考的松、云南白药酊、达克罗宁制备的鼻腔消炎止血药膜,制备简便,质量稳定。临床观察结果证明,具有给药方便、疗效高、疗程短、药物作用持久,无毒副作用等优点。 相似文献
64.
65.
云南省卫生资源配置标准的弹性系数研究 总被引:2,自引:1,他引:1
目的 在进行云南省区域分类基础上制定云南省区域卫生资源配置标准标志值后 ,根据云南省各个地区的特点增加不同弹性系数。方法 采用流行病学研究方法 ,收集和分析云南省不同地州市 1990~ 1999年有关人口、社会经济状况及卫生经费的投入、居民健康状况、居民文化、生活水平、少数民族状况、旅游地区、边境线长短及贫困状况等资料。结果 研究结果表明曲靖地区、玉溪市、保山地区增加弹性系数最少 ,分别为 0 67%、 1 5 8%和1 68% ,怒江州、迪庆州和西双版纳州增加弹性系数最多 ,分别为 11 15 %、 10 2 5 %和 9 84 %。其它地区的弹性系数分别为昆明市 5 88% ,昭通地区 2 3 1% ,楚雄州 2 3 0 % ,红河州 7 0 3 % ,文山州 5 5 3 % ,思茅地区 7 4 3 % ,大理州4 94 % ,德宏州 6 78% ,丽江地区 4 3 5 % ,临沧地区 6 13 %。结论 云南省区域卫生配置标准的弹性系数研究为云南省卫生资源区域分类配置标准提供了科学依据 ,不同弹性系数体现了云南省不同地区的卫生资源区域分类配置标准的公平性、合理性及实用性 相似文献
66.
本文对精神分裂症患者用氯丙嗪治疗前后PAg(T)功能进行观察及BPRS评定,发现精分症患者PAg(T)功能明显高于对照组,用氯丙嗪治疗1个月后,BPRS评定分值下降,患者临床症状消除,而PAg(T)第一时相无变化,第二时相明显升高,说明氯丙嗪聚药物可促发血小板释放内源性致聚物质,同时也说明患者PAg(T)异常不仅仅是情绪应激所致,更重要的是血小板生理功能异常。 相似文献
67.
A 12-year-old girl with a history of fast myopia progression underwent advanced orthokeratology (ortho-k) treatment and suffered from recurrent lens binding and central corneal staining. The problem could not be fixed by lens fenestration and refitting with a less aggressive lens (three-zone ortho-k) design. After refitting with a lower target advanced ortho-k lens, these complications were no longer occurring, and the amount of power reduction was greater than expected considering the target designed for the refitted lenses. During the following 15 months of ortho-k lens wear, there was no clinically significant change to her refractive error. The patient and her parents were happy with the outcome, although the refractive error was not totally eliminated and she still needed to wear spectacles for clear vision. Possible etiologies of the complications are discussed. 相似文献
68.
W. Y. Zhang Research Fellow A. Li Wan Po Professor 《BJOG : an international journal of obstetrics and gynaecology》1998,105(7):780-789
Objective To quantify the efficacy and safety of naproxen, ibuprofen, mefenamic acid, aspirin and acetaminophen (paracetamol) in the treatment of primary dysmenorrhoea through a systemic overview of randomised controlled trials.
Methods MEDLINE, EMBASE and the Science Citation Index were searched for randomised controlled trials. Efficacy was assessed by measurement of pain relief, requirement for rescue analgesics, restriction of daily life and absence from work or school. The rate ratios of side effects were used to assess safety.
Results Fifty-six trials describing 55 comparisons of analgesics with placebo and 12 direct comparisons with other analgesics met our inclusion criteria. Women taking naproxen were over three times more likely to have at least moderate pain relief than those taking placebo. Ibuprofen, mefenamic acid and aspirin were also superior to placebo but acetaminophen was not. The requirement for rescue analgesics, restriction of daily life and absence from work or school were less frequent with naproxen and ibuprofen than placebo but not with aspirin or acetaminophen. Direct comparisons did not show any difference between naproxen and ibuprofen. Side effects occurred more frequently only with naproxen when compared with placebo.
Conclusion Naproxen, ibuprofen, mefenamic acid and aspirin are all effective in primary dysmenorrhoea. Ibuprofen appears to have the most favourable risk-benefit ratio. Acetaminophen appears to be less effective than nonsteroidal anti-inflammatory drugs, but there was only one trial meeting our inclusion criteria and further studies are required. 相似文献
Methods MEDLINE, EMBASE and the Science Citation Index were searched for randomised controlled trials. Efficacy was assessed by measurement of pain relief, requirement for rescue analgesics, restriction of daily life and absence from work or school. The rate ratios of side effects were used to assess safety.
Results Fifty-six trials describing 55 comparisons of analgesics with placebo and 12 direct comparisons with other analgesics met our inclusion criteria. Women taking naproxen were over three times more likely to have at least moderate pain relief than those taking placebo. Ibuprofen, mefenamic acid and aspirin were also superior to placebo but acetaminophen was not. The requirement for rescue analgesics, restriction of daily life and absence from work or school were less frequent with naproxen and ibuprofen than placebo but not with aspirin or acetaminophen. Direct comparisons did not show any difference between naproxen and ibuprofen. Side effects occurred more frequently only with naproxen when compared with placebo.
Conclusion Naproxen, ibuprofen, mefenamic acid and aspirin are all effective in primary dysmenorrhoea. Ibuprofen appears to have the most favourable risk-benefit ratio. Acetaminophen appears to be less effective than nonsteroidal anti-inflammatory drugs, but there was only one trial meeting our inclusion criteria and further studies are required. 相似文献
69.
吗啡对机械通气病人的应用 总被引:1,自引:0,他引:1
为获得病人在接受呼吸机期间充分的镇静、良好的耐管并与呼吸机合拍达到满意的治疗效果,对60例不同年龄的患者在进行呼吸机支持治疗期间,采用平均045mg/(kgd)的吗啡量持续微量泵静脉注入,间断辅助安定的方法.用药后连续2h观察血压、心率、呼吸、意识等变化.结果:在用药期间病人血压、心率、呼吸平稳,保持清醒,安静耐管,解决了病人与呼吸机拮抗的矛盾.结果表明:该法在临床上有广泛使用价值 相似文献
70.
计算机在医学领域中的应用及展望 总被引:2,自引:0,他引:2
对计算机在医学文献检索、医学统计软件包的编制、疾病诊断、医院管理等医学领域中的应用作了简要的综述,并对未来的发展进行了预测。 相似文献