Effectiveness of an Intensive Outpatient Program for Disruptive Children: Initial Findings

There are currently no manualized, intensive outpatient programs (IOP), for diagnostically heterogeneous pediatric samples that simultaneously intervene with youth and parents. Such a program was developed and has been operating at Children’s Hospital Colorado since January 2006. The current study was conducted to characterize the patient sample and evaluate clinical outcomes for this novel program. The study used a method of retrospective chart review to examine demographic and diagnostic information of youth and their families, who participated in IOP. Clinical outcomes were similarly assessed, using paired-samples t test comparisons of the baseline and endpoint parent-report versions of the Ohio Youth Outcome Scales. Results indicated that there were statistically significant differences in each of the Subscale scores on the Ohio Youth Scales from baseline to endpoint of IOP. Preliminary findings suggest that participation in the IOP program was associated with improved clinical outcomes, at the end of treatment.     

酪氨酸相关肽的合成及抗孕酮生成活性

利用固相法合成了二十个含羟基氨基酸的小肽。其中，以０．５ｍｏｌ·Ｌ－１二甲二氯硅烷／１．５ｍｏｌ·Ｌ－１苯酚／ＤＣＭ＊为脱除Ｂｏｃ试剂，以ＴＦＭＳＡ为切除树脂试剂。经Ｃ－１８反相柱纯化后，全部产物均通过氨基酸分析要求。体外黄体细胞分泌孕酮实验表明有八个肽化物ＧｌｙＴｙｒＡｌａＬｙｓ，（ＳａｒＳｅｒ）２Ｌｙｓ及其申酯，ＴｙｒＬｙｓ，ＨｉｓＴｙｒ－ＮＨ２，ＴｈｒＰｒｏＴｙｒＬｙｓ－ＮＨ２，ＴｙｒＴｈｒＰｒｏＡｒｇＬｙｓ，ＡｓｐＨｉｓＰｒｏＴｈｒ－ＰｈｅＬｙｓ显示较强的抑制ｈＣＧ致孕酮分泌的活性，而且前三个肽还能显著抑制基础孕酮的分泌，相反，ＧｌｙＳｅｒＴｙｒ能刺激基础孕酮的分泌。目前尚未建立合理的结构一活性关系。     

Birth-weight of Newborns to Chinese Women Subsequent to a Previous Abortion

The mean birth-weight of firstborns of women was significantly higher when there was a previous abortion. The increase was 73.5 and 119.4 g in newborns of women with an induced and a spontaneous abortion respectively. This trend of significant increased birth-weight among firstborns of women with either a previous induced or spontaneous abortion continued for male infants, in recent migrants, and in subjects aged 20-24 and 30-34 years. Stepwise logistic regression analyses showed that a history of an induced or a spontaneous abortion increased the birth-weight of the firstborns, while short maternal stature and female newborn were associated with decreased birth-weight. For low birth-weight, a previous abortion was not selected into the regression models but short maternal stature and female newborns continue to contribute to low birth-weight. Prematurity and mean gestation were found not to be associated with previous abortion using logistic regression analyses.     

N,N′-亚烷基双(取代苯酚)氨基乙酸的合成及对放射性核素钍-234的促排效果

本文报道合成的16个N,N′-亚烷基双(取代苯酚)氨基乙酸除化合物3,4外对放射性钍-234的加速排出均有较好的效果。其中有二个化合物促排效果达到70%以上,根据动物实验结果初步探讨了构效关系。     

黄花远志根中两个新■酮化合物的结构鉴定

从黄花远志（ＰｏｌｙｇａｌａａｒｉｌａｔａＢｕｃｈＨａｍ．）根中分离得到两个新的酮化合物，根据理化性质和光谱（ＵＶ，ＩＲ，ＭＳ，１ＨＮＭＲ，ＤＩＦＮＯＥ和１３ＣＮＭＲ）分析，分别鉴定为１，３二羟基２甲氧基酮（Ｉ）和７羟基１甲氧基２，３亚甲二氧基酮（Ｉ）。药理试验表明Ｉ，Ｉ均具有抑制醛糖酶的作用。     

促性腺激素释放多肽(GRP)对体外培养小鼠垂体分泌LH的影响

合成的促性腺激素释放多肽(GRP)及其类似物GRp～NH₂,[Glu^7.9.14Lys^6.10]GRP(6～14),[phe¹⁴]GRP(5～14)和[phe¹⁴]GRP浓度在0.05mmol·L^-1时,具有刺激体外培养的小鼠垂体分泌LH的作用。其活性依此相当对照垂体的115.4,114.2,140,160和179%。小鼠于妊振第7～9天或第1～5天,每只sc[phe¹⁴]GRP1mg·d^-1,或于妊娠第2～4天每只sc[phe¹⁴]GRP(5～14)1mg·d^-1,有40～60%的妊娠动物出现死胎。     

Chronic Childhood Illness and Maternal Mental Health—Why Should We Care?

This study evaluated which factors most influenced the impact of childhood asthma on the child's family. Seventy children/families seen at a tertiary-care hospital for asthma were evaluated. Stepwise multiple regression examined the effects of illness severity; family socioeconomic status (SES); family structure; social support; child's emotional characteristics; parent's health; family functioning; and maternal psychological distress on the Family Impact of Illness Scale. Analysis indicated that only the parent's Psychiatric Symptom Index significantly predicted impact scores. The most important predictors of how much impact a child's asthma has on the family are parental emotional distress and amount of social support.     

气态污染物与上海市浦东新区居民心脑血管疾病死亡相关性的病例交叉研究

目的 评估气态污染物与浦东新区居民每日心脑血管疾病死亡的关联性,为制定相应的干预措施提供依据。方法 收集浦东新区2005年1月1日-2017年12年31日的气象因素、大气污染及居民心脑血管疾病死亡资料,采用时间分层-病例交叉研究的方法,评估气态污染物对浦东新区居民心脑血管疾病死亡的影响。结果 研究期间,上海市SO2与NO2的平均浓度分别为31.96μg/m3和45.21μg/m3。SO2与NO2与浦东新区居民心脑血管疾病死亡存在相关性。SO2与NO2的效应分别在滞后3d（lag3）与当日（lag0）强度最大,SO2浓度每上升10μg/m3,在滞后3d（lag3）时居民每日心脑血管疾病死亡将上升1.12%(95%CI:0.69%～1.56%);NO2浓度每上升10μg/m3,在当日居民每日心脑血管疾病死亡将上升0.85%(95%CI:0.40%～1.30%)。多污染物模型中,在控制了PM10与NO2的影响后,SO2的效应保持稳定,在控制了PM10与SO2的影响后,NO2的效应有所加强。结论 SO2与NO2浓度与每日浦东新区居民心脑血管疾病死亡存在相关性,其中SO2的效应在滞后3d影响最大,NO2在当日影响最大。