全文获取类型
收费全文 | 143268篇 |
免费 | 7604篇 |
国内免费 | 207篇 |
专业分类
耳鼻咽喉 | 2012篇 |
儿科学 | 5807篇 |
妇产科学 | 4413篇 |
基础医学 | 19894篇 |
口腔科学 | 3450篇 |
临床医学 | 10841篇 |
内科学 | 27183篇 |
皮肤病学 | 3824篇 |
神经病学 | 11981篇 |
特种医学 | 6154篇 |
外国民族医学 | 87篇 |
外科学 | 22789篇 |
综合类 | 1952篇 |
一般理论 | 39篇 |
预防医学 | 7945篇 |
眼科学 | 4150篇 |
药学 | 9935篇 |
中国医学 | 354篇 |
肿瘤学 | 8269篇 |
出版年
2019年 | 998篇 |
2018年 | 1316篇 |
2017年 | 1124篇 |
2016年 | 1479篇 |
2015年 | 1744篇 |
2014年 | 2301篇 |
2013年 | 3414篇 |
2012年 | 4644篇 |
2011年 | 4746篇 |
2010年 | 2847篇 |
2009年 | 2753篇 |
2008年 | 4775篇 |
2007年 | 5118篇 |
2006年 | 5185篇 |
2005年 | 5327篇 |
2004年 | 5188篇 |
2003年 | 4967篇 |
2002年 | 4885篇 |
2001年 | 7373篇 |
2000年 | 7271篇 |
1999年 | 6184篇 |
1998年 | 1922篇 |
1997年 | 1849篇 |
1996年 | 1587篇 |
1995年 | 1440篇 |
1994年 | 1299篇 |
1993年 | 1326篇 |
1992年 | 3981篇 |
1991年 | 3773篇 |
1990年 | 3740篇 |
1989年 | 3537篇 |
1988年 | 3168篇 |
1987年 | 3072篇 |
1986年 | 2961篇 |
1985年 | 2783篇 |
1984年 | 2153篇 |
1983年 | 1778篇 |
1982年 | 1147篇 |
1981年 | 1121篇 |
1980年 | 955篇 |
1979年 | 1982篇 |
1978年 | 1497篇 |
1977年 | 1215篇 |
1976年 | 1076篇 |
1975年 | 1302篇 |
1974年 | 1359篇 |
1973年 | 1309篇 |
1972年 | 1137篇 |
1971年 | 1066篇 |
1970年 | 945篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
81.
Phenytoin-induced gingival overgrowth is a recognized side effect in many cerebral palsy patients using diphenyl hydantoin for the control of seizures. Severe gingival overgrowth in these patients can affect normal masticatory function, lead to poor occlusal development, and compromise esthetics. This report addresses the complex nature of treating phenytoin-induced gingival overgrowth in a mentally retarded 20-year-old female patient. For this patient, full-mouth gingivectomy procedure was performed under general anesthesia in a single session. Post operative follow-up was uneventful. This article discusses major indications, contraindications, and protocols to be followed for periodontal surgical procedures done under general anesthesia. 相似文献
82.
PD Dr. U. Germer 《Der Gyn?kologe》2005,38(6):553-554
Ohne Zusammenfassung 相似文献
83.
M. Knappik U. Börner T. Jelinek 《European journal of clinical microbiology & infectious diseases》2005,24(10):701-703
The study presented here was conducted to evaluate the performance of the newly available RIDASCREEN Set (R-Biopharm AG, Darmstadt,
Germany) for the detection of immunoglobulin G antibodies against Entamoeba histolytica. The sensitivity and specificity of this new enzyme-linked immunosorbent assay were evaluated using a panel of sera from
239 individuals. The assay was positive for 43 of 44 patients with invasive amebiasis, including all 18 patients with amebic
liver abscess, while it was negative for 190 of 195 adult controls who were either healthy individuals or patients with other
parasitic diseases. The kit was found to be highly specific (97.4%) and sensitive (97.7%) for detecting antibodies against
E. histolytica in humans. Although antibody titers in patients with amebic liver abscess tend to be higher on average than in patients with
invasive amebiasis, it is not possible to distinguish the two forms solely based on the results of this commercial test. 相似文献
84.
The detection of antineuronal antibodies against cytoplasm and nuclei of Purkinje cells is considered to be an essential factor in the diagnosis of neurologic paraneoplastic syndromes. Published data rely on different immunological methods and relatively small numbers of patients. The clinical relevance of this phenomenon is not clear from the literature. A positive correlation between antibody detection and the appearance of neurologic paraneoplastic syndromes has been reported, but this finding has been questioned in critical reviews. 相似文献
85.
Walter S. Nimmo 《Journal canadien d'anesthésie》1989,36(Z1):S45-S47
An understanding of factors which influence gastric emptying rate is important for anaesthetists. In the absence of pyloric
stenosis or other mechanical obstruction to the gastric outlet, opioid drugs constitute the most important cause of delayed
emptying in the perioperative period. 相似文献
86.
Summary A necrotizing, nonprogressive myopathy with unusual paracrystalline inclusion bodies is described in a patient who underwent long-term treatment with megadoses of vitamin E. The clinical course and morphological findings suggest a close relationship to the administration of the vitamin. The theoretical pathogenesis of muscle damage and the possible origin of paracrystalline inclusion bodies are discussed.Presented at the Jahrestagung der österreichischen Gesellschaft für Neuropathologie in Bad Ischl, on April 17, 1986This study was supported by a grant from the Deutsche Forschungsgemeinschaft (Ba 916) 相似文献
87.
Bergner Raoul; Hoffmann Martin; Riedel Klaus-Dieter; Mikus Gerd; Henrich Dirk M.; Haefeli Walter E.; Uppenkamp Michael; Walter-Sack Ingeborg 《Nephrology, dialysis, transplantation》2006,21(4):1019-1023
To cover intermediate sensitive Candida glabrata in ICU patients,fluconazole plasma peak levels at least in the range of 1632µg/ml appear necessary for treatment. Previous studiesdid not reach these fluconazole levels under continuous veno-venoushaemofiltration (CVVHF) with dosages of 200600 mg fluconzoledaily. In the present study, nine patients simultaneously requiringCVVHF for treatment of acute oligoanuric renal failure and antimycotictherapy of Candida septicemia received fluconazole 800 mg/day.Fluconazole plasma levels were determined to evaluate whetherthis dosage is adequate to reach the advised fluconazole levels.Patients were dialysed on two consecutive days with an ultrafiltrationrate (UF) of 1000 ml/h or 2000 ml/h, respectively, in a randomizedorder. The predilution was 800 ml/h and 1800 ml/h, respectively.The treatment was tolerated without adverse effects. All patientsreached plasma fluconazole concentrations between 16 and 32µg/ml, remaining in this range for a minimum of 1 up to24 h with a mean of 9.6 h and a UF rate of 2000 ml/h, and 15.7h with a UF rate of 1000 ml/h. So far, there are no in vivodata on the fluconazole plasma concentrations required for effectivetreatment. However, our data demonstrate, that at least thefluconazole concentrations desirable on the basis of in vitrosusceptibility testing can be reached in critically ill patientson CVVHF in an ICU setting. However, in these patients, 800mg fluconazole/day are necessary to achieve fungicidal drugconcentrations. 相似文献
88.
P B Schneider U Denk M Breitenbach K Richter P Schmid-Grendelmeier S Nobbe M Himly A Mari C Ebner B Simon-Nobbe 《Clinical and experimental allergy》2006,36(12):1513-1524
BACKGROUND: Alternaria alternata is one of the most important allergenic fungi worldwide. Mannitol dehydrogenase (MtDH) has previously been shown to be a major allergen of Cladosporium herbarum and cross-reactivity has been demonstrated for several fungal allergens. OBJECTIVE: The present study's objective was to clone the MtDH from an A. alternata cDNA library, express and purify the recombinant non-fusion protein and test its IgE-binding properties. Methods A cDNA library prepared from A. alternata hyphae and spores was screened for mannitol dehydrogenase by DNA hybridization with the radioactively labelled C. herbarum homologue as a probe. The resulting clone was sequenced and heterologously expressed in Escherichia coli as a recombinant non-fusion protein, which was purified to homogeneity and analysed for its IgE-binding capacity. RESULTS: The coding sequence of the full-length cDNA clone comprises 798 bp encoding a protein with a molecular mass of 28.6 kDa and a predicted pI of 5.88. Protein sequence analysis revealed an identity of 75% and a homology of 86% between the MtDHs of A. alternata and C. herbarum. The functional mannitol dehydrogenase was expressed in the E. coli strain BL21(DE3) transformed with the vector pMW172 and purified to homogeneity. The enzyme catalyses the NADPH-dependent conversion of d-fructose to d-mannitol. In IgE-ELISA and immunoblots, MtDH is recognized by 41% of A. alternata-allergic patients. In vivo immunoreactivity of the recombinant MtDH was verified by skin prick testing. Finally, inhibition-ELISA experiments confirmed cross-reactivity between the MtDHs of A. alternata and C. herbarum. CONCLUSION: Mannitol dehydrogenase (Alt a 8) represents an important new allergen of the ascomycete A. alternata that might be suitable for improving diagnostic and therapeutic procedures. 相似文献
89.
Walter S Speidl Markus Exner Jasmin Amighi Wolfgang Mlekusch Schila Sabeti Stefan P Kastl Gerlinde Zorn Gerald Maurer Oswald Wagner Kurt Huber Erich Minar Johann Wojta Martin Schillinger 《Journal of endovascular therapy》2007,14(1):62-69
PURPOSE: To investigate whether balloon angioplasty of the superficial femoral artery (SFA) increases serum levels of C5a and whether C5a predicts risk of restenosis. METHODS: C5a antigen was measured at baseline and 8 hours after intervention in 131 consecutive patients (76 women; median age 72 years) with intermittent claudication who underwent successful primary SFA balloon angioplasty. Patients were followed for a median 10 months [interquartile range (IQR) 6 to 14] for the occurrence of >50% restenosis by duplex ultrasound. RESULTS: Median C5a levels increased significantly from 39.7 ng/mL (IQR 27.8 to 55.0) at baseline to 53.8 ng/mL (IQR 35.6 to 85.1, p<0.001) 8 hours post intervention. During the follow-up period, 70 (53%) patients developed restenosis. Increasing levels of C5a (quartiles) at baseline were significantly associated with an increased risk for restenosis (p=0.0092). Adjusted hazard ratios (95% confidence intervals) for restenosis with increasing quartiles of baseline serum C5a levels were 1.24 (0.60 to 2.58), 1.93 (0.95 to 3.93), and 2.08 (1.02 to 4.21), respectively, compared to the lowest quartile. This effect was independent of nonspecific inflammation as reflected by plasma levels of C-reactive protein. CONCLUSION: Inflammatory mechanisms play a major role in the development of restenosis after angioplasty. The complement component C5a exerts strong chemotactic and proinflammatory effects. Enhanced complement activation prior to PTA, as measured by higher levels of C5a, was significantly associated with restenosis after SFA balloon angioplasty. Pathways of complement inhibition thus may be worth investigating with respect to improving patency rates. 相似文献
90.