Immunologic aspect of ovarian cancer and p53 as tumor antigen

Ovarian cancer represents the fifth leading cause of death from all cancers for women. During the last decades overall survival has improved due to the use of new chemotherapy schedules. Still, the majority of patients die of this disease. Research reveals that ovarian cancer patients exhibit significant immune responses against their tumor. In this review the knowledge obtained thus far on the interaction of ovarian cancer tumor cells and the immune system is discussed. Furthermore the role of p53 as tumor antigen and its potential role as target antigen in ovarian cancer is summarized. Based on the increased knowledge on the role of the immune system in ovarian cancer major improvements are to be expected of immunotherapy based treatment of this disease.     

Computed tomography and radionuclide imaging in the evaluation of ischemic stroke

One hundred forty-one patients with cerebral or cerebellar infarction were examined by computed tomography (CT) as soon after the ictus as possible. The examination was repeated in 7 days, and a radionuclide brain scan was performed. The overall detection rate for ischemic infarction was approximately equal for both techniques, ranging from 58% for radionuclide scanning to 66% for the delayed CT. Almost half of the supratentorial infarcts examined by CT on the day of the ictus were demonstrated. Mass effect was observed as early as the first day and as late as the 25th day.     

活体生物萤光成像技术新进展

活体生物萤光成像技术(in vivo biolumines- cence imaging)是近年来发展起来的一项崭新的分子、基因表达的分析检测系统．与传统的检测方法相比具有巨大的优越性,堪称是分子基因检测领域的革命性技术．随着萤光成像设备的进一步完善以及转基因动物的构建开发,在欧美等发达国家活体生物萤光成像技术已被广泛地应用于感染、肿瘤免疫及治疗、自身免疫性疾病、器官移植、基因治疗、药物开发等实验领域．本文就活体生物萤光成像技术的发展和应用作如下综述．     

Luminance-modulated adaptation in the global flash mfERG: a preliminary study of early retinal functional changes in high-risk glaucoma patients

Purpose  

To investigate the association of the luminance-modulation global flash multifocal electroretinogram (mfERG) and other clinical assessments of vision in subsets of subjects at high risk of developing glaucomatous damage.