全文获取类型
收费全文 | 1132篇 |
免费 | 66篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 19篇 |
妇产科学 | 19篇 |
基础医学 | 100篇 |
口腔科学 | 126篇 |
临床医学 | 65篇 |
内科学 | 280篇 |
皮肤病学 | 4篇 |
神经病学 | 104篇 |
特种医学 | 40篇 |
外科学 | 147篇 |
综合类 | 4篇 |
一般理论 | 1篇 |
预防医学 | 87篇 |
眼科学 | 30篇 |
药学 | 123篇 |
肿瘤学 | 40篇 |
出版年
2023年 | 7篇 |
2022年 | 12篇 |
2021年 | 26篇 |
2020年 | 28篇 |
2019年 | 19篇 |
2018年 | 20篇 |
2017年 | 21篇 |
2016年 | 26篇 |
2015年 | 23篇 |
2014年 | 33篇 |
2013年 | 55篇 |
2012年 | 80篇 |
2011年 | 66篇 |
2010年 | 58篇 |
2009年 | 56篇 |
2008年 | 89篇 |
2007年 | 77篇 |
2006年 | 73篇 |
2005年 | 58篇 |
2004年 | 61篇 |
2003年 | 65篇 |
2002年 | 57篇 |
2001年 | 20篇 |
2000年 | 10篇 |
1999年 | 15篇 |
1998年 | 15篇 |
1997年 | 6篇 |
1996年 | 8篇 |
1995年 | 8篇 |
1994年 | 10篇 |
1993年 | 6篇 |
1992年 | 21篇 |
1991年 | 14篇 |
1990年 | 14篇 |
1989年 | 13篇 |
1988年 | 6篇 |
1987年 | 2篇 |
1985年 | 2篇 |
1983年 | 2篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1978年 | 1篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1971年 | 1篇 |
1968年 | 1篇 |
1966年 | 3篇 |
1965年 | 1篇 |
排序方式: 共有1200条查询结果,搜索用时 0 毫秒
41.
Katerina Karageorgou Panos Katerelos Andreas Efstathiou Maria Theodoridou Helena C. Maltezou 《Vaccine》2014
Background
Vaccination of healthcare students is important to protect them from acquiring and transmitting vaccine-preventable diseases (VPDs) to high-risk patients and other healthcare workers (HCWs). The aim of the current study was to estimate the vaccination coverage, the susceptibility against VPDs, the knowledge and attitudes toward vaccinations of healthcare students studying at the Athens Technological Educational Institute.Methods
The study was conducted during the academic year 2012–2013 using a standardized questionnaire.Results
The mean knowledge score (correct answers) of healthcare students about the vaccines that are recommended by the Greek Ministry of Health for HCWs was 41%. Completed vaccination rates range from 19.6% for varicella to 80.2% for tetanus-diphtheria. A history of measles, mumps, rubella, varicella, hepatitis A, hepatitis B, or pertussis was reported by 8.2%, 4%, 5.4%, 70.4%, 1.5%, 0%, and 3% of students, respectively. Susceptibility rates were 20.5% against measles, 26.4% against mumps, 13.9% against rubella, 15.7% against varicella, 47.8% against hepatitis A, 17.3% against hepatitis B, and 19.8% against tetanus–diphtheria. Mandatory vaccination of HCWs was supported by 145 (96.7%) students.Conclusions
There are significant immunity gaps against all VPDs among healthcare students in Athens. A system to easily identify non-immune students should be established in association with efficient reminder systems. Education of healthcare students about VPDs and vaccines will improve their attitudes toward vaccinations and their vaccination coverage. Mandatory vaccinations should be considered for HCWs in order to promote safety within healthcare facilities. 相似文献42.
Juliette K. Tinker Jie Yan Reece J. Knippel Panos Panayiotou Kenneth A. Cornell 《Toxins》2014,6(4):1397-1418
West Nile virus (WNV) causes potentially fatal neuroinvasive disease and persists at endemic levels in many parts of the world. Despite advances in our understanding of WNV pathogenesis, there remains a significant need for a human vaccine. The domain III (DIII) region of the WNV envelope protein contains epitopes that are the target of neutralizing antibodies. We have constructed a chimeric fusion of the non-toxic cholera toxin (CT) CTA2/B domains to DIII for investigation as a novel mucosally-delivered WNV vaccine. Purification and assembly of the chimera, as well as receptor-binding and antigen delivery, were verified by western blot, GM1 ELISA and confocal microscopy. Groups of BALB/c mice were immunized intranasally with DIII-CTA2/B, DIII, DIII mixed with CTA2/B, or CTA2/B control, and boosted at 10 days. Analysis of serum IgG after 14 and 45 days revealed that mucosal immunization with DIII-CTA2/B induced significant DIII-specific humoral immunity and drove isotype switching to IgG2a. The DIII-CTA2/B chimera also induced antigen-specific IgM and IgA responses. Bactericidal assays indicate that the DIII-CTA2/B immunized mice produced DIII-specific antibodies that can trigger complement-mediated killing. A dose escalation resulted in increased DIII-specific serum IgG titers on day 45. DIII antigen alone, in the absence of adjuvant, also induced significant systemic responses after intranasal delivery. Our results indicate that the DIII-CTA2/B chimera is immunogenic after intranasal delivery and merits further investigation as a novel WNV vaccine candidate. 相似文献
43.
Emmanuel G Manios Eleftherios M Kallergis Emmanuel M Kanoupakis Hercules E Mavrakis Helen K Mouloudi Nikolaos K Klapsinos Panos E Vardas 《Europace : European pacing, arrhythmias, and cardiac electrophysiology》2005,7(1):34-39
AIM: Changes in ventricular refractoriness and repolarization after successful electrical cardioversion to sinus rhythm in persistent atrial fibrillation (AF) patients were studied. METHODS AND RESULTS: In 33 AF patients with controlled ventricular response, right ventricular ERP (VERP) at three basic cycle lengths (600, 500, 400 ms), as well as monophasic action potential duration (MAPd(90)) at a drive cycle length of 500 ms, were measured just before, 20 min and 24 h after cardioversion. VERP at 600 ms changed from 241+/-19 ms to 249+/-21 ms to 253+/-24 ms (P<0.001), VERP at 500 ms changed from 234+/-19 ms to 242+/-22 ms to 246+/-23 ms (P<0.001) and VERP at 400 ms changed from 224+/-20 ms to 232+/-23 ms to 236+/-24 ms (P<0.001). MAPd(90) changed from 247+/-16 ms preconversion to 252+/-17 ms 20 min postconversion to 253+/-19 ms after 24 h (P<0.05). Change in refractoriness at 500 ms was well correlated with change of mean RR interval before and 20 min after conversion (R=0.616, P<0.001). There was no correlation between RR variability and VERP before cardioversion. CONCLUSION: Restoration of sinus rhythm in persistent AF patients is followed by significant effects on ventricular refractoriness and repolarization related to cycle length change. No AF related ventricular electrophysiological alterations were found. 相似文献
44.
Dimitrios Asvestas Vasileios Sousonis George Kotsovolis Stavros Karanikas Anastasia Xintarakou Eleftherios Sakadakis Angelos G. Rigopoulos Andreas S. Kalogeropoulos Panos Vardas Stylianos Tzeis 《Clinical cardiology》2022,45(5):503
BackgroundForce‐time integral (FTI) is an ablation marker of lesion quality and transmurality. A target FTI of 400 gram‐seconds (gs) has been shown to improve durability of pulmonary vein isolation, following atrial fibrillation ablation. However, relevant targets for cavotricuspid isthmus (CTI) ablation are lacking.HypothesisWe sought to investigate whether CTI ablation with 600 gs FTI lesions is associated with reduced rate of transisthmus conduction recovery compared to 400 gs lesions.MethodsFifty patients with CTI‐dependent flutter were randomized to ablation using 400 gs (FTI400 group, n = 26) or 600 gs FTI lesions (FTI600 group, n = 24). The study endpoint was spontaneous or adenosine‐mediated recovery of transisthmus conduction, after a 20‐min waiting period.ResultsThe study endpoint occurred in five patients (19.2%) in group FTI400 and in four patients (16.7%) in group FTI600, p = .81. First‐pass CTI block was similar in both groups (50% in FTI400 vs. 54.2% in FTI600, p = .77). There were no differences in the total number of lesions, total ablation time, procedure time and fluoroscopy duration between the two groups. There were no major complications in any group. In the total population, patients not achieving first‐pass CTI block had significantly higher rate of acute CTI conduction recovery, compared to those with first‐pass block (29.2% vs. 7.7% respectively, p = .048).ConclusionsCTI ablation using 600 gs FTI lesions is not associated with reduced spontaneous or adenosine‐mediated recurrence of transisthmus conduction, compared to 400 gs lesions. 相似文献
45.
Christoforakis JJ Kontakis GM Katonis PG Maris T Voloudaki A Prassopoulos P Hadjipavlou AG 《Acta orthopaedica Belgica》2003,69(3):226-232
Sixteen patients, with a fracture of the upper humerus treated with hemiarthroplasty, were followed-up for 45.7 +/- 15.1 (20-72) months after surgery. The results were assessed using the Constant-Murley scale. The mean score was 75.8 +/- 15.7 (54-96) points out of a possible maximum of 100. At the time of their last follow-up they underwent CT of the fractured and contralateral humerus. Humeral length and retroversion were measured and evaluated. A very good final outcome (Constant score more than 71) was achieved in patients with a difference in retroversion less than 10 degrees and a difference in length less than 14 mm, between fractured and sound humerus. The mean difference in retroversion was 8.7 degrees and the mean difference in length was 0.65 cm, between fractured and sound humerus. We attribute the very good clinical outcome in our series to the quality of the anatomical reconstruction that was performed. 相似文献
46.
John S. Yi PhD Jeffrey T. Guptill MD Panos Stathopoulos MD PhD Richard J. Nowak MD Kevin C. O’Connor PhD 《Muscle & nerve》2018,57(2):172-184
Myasthenia gravis (MG) is an archetypal autoimmune disease. The pathology is characterized by autoantibodies to the acetylcholine receptor (AChR) in most patients or to muscle‐specific tyrosine kinase (MuSK) in others and to a growing number of other postsynaptic proteins in smaller subsets. A decrease in the number of functional AChRs or functional interruption of the AChR within the muscle end plate of the neuromuscular junction is caused by pathogenic autoantibodies. Although the molecular immunology underpinning the pathology is well understood, much remains to be learned about the cellular immunology contributing to the production of autoantibodies. This Review documents research concerning the immunopathology of MG, bringing together evidence principally from human studies with an emphasis on the role of adaptive immunity and B cells in particular. Proposed mechanisms for autoimmunity, which take into account that different types of MG may incorporate divergent immunopathology, are offered. Muscle Nerve 57 : 172–184, 2018 相似文献
47.
48.
Subgingival bacterial clusters and serum antibody response as markers of extent and severity of periodontitis in adult Chinese 下载免费PDF全文
Gunnar Dahlén Wen‐Min Luan Ulf Dahlgren Panos P. Papapanou Vibeke Baelum Ole Fejerskov 《European journal of oral sciences》2016,124(2):179-187
This study evaluated the associations between clinical, microbiological, and antibody activity manifestations of periodontitis in 123 adult rural Chinese subjects with no dental intervention. All participants were registered for full‐mouth clinical attachment level (CAL) and pocket probing depth (PD) measurements, and microbial samples were taken from four sites and analyzed for 18 different bacterial species using the ‘checkerboard’. Serum from each individual was analyzed to determine the antibody activity against the same 18 species. Exploratory factor analysis disclosed two microbial factors – Factor 1, consisting of seven species associated with periodontal health (‘early colonizers’); and Factor 2, consisting of eight species associated with periodontitis (‘putative periodontopathogens’) – which explained 87% of the variation among the microbial variables. Factor 2 was consistently associated with disease‐severity measures, whereas the ‘early colonizer’ factor was not. The antibody response showed weak or no correlations with bacterial load or with disease severity. We conclude that the bacteria investigated are resident in the subgingival plaque; that their load and proportions in the pocket may be ecologically driven; and that the antibody response is based on bacterial carrier state rather than on disease. The different antibody‐response pattern found between the individuals may suggest that each individual could be classified as a good or a weak immune responder. 相似文献
49.
Implant survival rates and biologic complications with implant‐supported fixed complete dental prostheses: A retrospective study with up to 12‐year follow‐up 下载免费PDF全文
50.
Carl A. Anderson Jeffrey C. Barrett Mark Tremelling Rhian Gwilliam Elaine R. Nimmo Charlie W. Lees Catherine Hanson Radhi Ravindrarajah Dhiraj Varma Gregory Lewis Nick Watkins David Strachan Cathryn M. Lewis Jeremy Sanderson Panos Deloukas Christopher G. Mathew Miles Parkes 《Gastroenterology》2009,136(2):523-529