全文获取类型
收费全文 | 3251篇 |
免费 | 218篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 128篇 |
妇产科学 | 83篇 |
基础医学 | 402篇 |
口腔科学 | 112篇 |
临床医学 | 280篇 |
内科学 | 790篇 |
皮肤病学 | 48篇 |
神经病学 | 269篇 |
特种医学 | 110篇 |
外科学 | 452篇 |
综合类 | 15篇 |
一般理论 | 1篇 |
预防医学 | 211篇 |
眼科学 | 36篇 |
药学 | 218篇 |
中国医学 | 6篇 |
肿瘤学 | 314篇 |
出版年
2023年 | 12篇 |
2022年 | 23篇 |
2021年 | 68篇 |
2020年 | 45篇 |
2019年 | 63篇 |
2018年 | 78篇 |
2017年 | 55篇 |
2016年 | 58篇 |
2015年 | 76篇 |
2014年 | 94篇 |
2013年 | 123篇 |
2012年 | 167篇 |
2011年 | 202篇 |
2010年 | 124篇 |
2009年 | 93篇 |
2008年 | 143篇 |
2007年 | 164篇 |
2006年 | 133篇 |
2005年 | 143篇 |
2004年 | 162篇 |
2003年 | 150篇 |
2002年 | 119篇 |
2001年 | 127篇 |
2000年 | 150篇 |
1999年 | 111篇 |
1998年 | 41篇 |
1997年 | 36篇 |
1996年 | 22篇 |
1995年 | 26篇 |
1994年 | 26篇 |
1993年 | 27篇 |
1992年 | 74篇 |
1991年 | 62篇 |
1990年 | 48篇 |
1989年 | 50篇 |
1988年 | 39篇 |
1987年 | 29篇 |
1986年 | 48篇 |
1985年 | 23篇 |
1984年 | 26篇 |
1983年 | 24篇 |
1982年 | 17篇 |
1981年 | 11篇 |
1979年 | 22篇 |
1978年 | 11篇 |
1977年 | 16篇 |
1970年 | 13篇 |
1969年 | 21篇 |
1968年 | 10篇 |
1966年 | 10篇 |
排序方式: 共有3484条查询结果,搜索用时 765 毫秒
41.
E. M. Rouiller G. M. Simm A. E. P. Villa Y. de Ribaupierre F. de Ribaupierre 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1991,86(3):483-505
Summary The origin and laminar arrangement of the homolateral and callosal projections to the anterior (AAF), primary (AI), posterior (PAF) and secondary (AII) auditory cortical areas were studied in the cat by means of electrophysiological recording and WGA-HRP tracing techniques. The transcallosal projections to AAF, AI, PAF and AII were principally homotypic since the major source of input was their corresponding area in the contralateral cortex. Heterotypic transcallosal projections to AAF and AI were seen, originating from the contralateral AI and AAF, respectively. PAF received heterotypic commissural projections from the opposite ventroposterior auditory cortical field (VPAF). Heterotypic callosal inputs to AII were rare, originating from AAF and AI. The neurons of origin of the transcallosal connections were located mainly in layers II and III (70–92%), and less frequently in deep layers (V and VI, 8–30%). Single unit recordings provided evidence that both homotypic and heterotypic transcallosal projections connect corresponding frequency regions of the two hemispheres. The regional distribution of the anterogradely labeled terminals indicated that the homotypic and heterotypic auditory transcallosal projections are reciprocal. The present data suggest that the transcallosal auditory interconnections are segregated in 3 major parallel components (AAF-AI, PAF-VPAF and AII), maintaining a segregation between parallel functional channels already established for the thalamocortical auditory interconnections. For the intrahemispheric connections, the analysis of the retrograde tracing data revealed that AAF and AI receive projections from the homolateral cortical areas PAF, VPAF and AII, whose neurons of origin were located mainly in their deep (V and VI) cortical layers. The reciprocal interconnections between the homolateral AAF and AI did not show a preferential laminar arrangement since the neurons of origin were distributed almost evenly in both superficial (II and III) and deep (V and VI) cortical layers. On the contrary, PAF received inputs from the homolateral cortical fields AAF, AI, AII and VPAF, originating predominantly from their superficial (II and III) layers. The homolateral projections reaching AII originated mainly from the superficial layers of AAF and AI, but from the deep layers of VPAF and PAF. The laminar distribution of anterogradely labeled terminal fields, when they were dense enough for a confident identification, was systematically related to the laminar arrangement of neurons of origin of the reciprocal projection: a projection originating from deep layers was associated with a reciprocal projection terminating mainly in layer IV, whereas a projection originating from superficial layers was associated with a reciprocal projection terminating predominantly outside layer IV. This laminar distribution indicates that the homolateral auditory cortical interconnections have a feed-forward/feed-back organization, corresponding to a hierarchical arrangement of the auditory cortical areas, according to criteria previously established in the visual system of primates. The principal auditory cortical areas could be ranked into 4 distinct hierarchical levels. The tonotopically organized areas AAF and AI represent the lowest level. The second level corresponds to the non-tonotopically organized area AII. Higher, the tonotopically organized areas VPAF and PAF occupy the third and fourth hierarchical levels, respectively.Abbreviations AAF
anterior auditory cortical area
- AI
primary auditory cortical area
- AII
secondary auditory cortical area
- BF
best frequency
- C
cerebral cortex
- CA
caudate nucleus
- CL
claustrum
- D
dorsal nucleus of the dorsal division of the MGB
- ea
anterior ectosylvian sulcus
- ep
posterior ectosylviansulcus
- IC
internal capsule
- LGN
lateral geniculate nucleus
- LV
pars lateralis of the ventral division of the MGB
- LVe
lateral ventricule
- M
pars magnocellularis of the medial division of the MGB
- MGB
medial geniculate body
- MGBv
ventral division of the MGB
- OT
optic tract
- OV
pars ovoidea of the ventral division of the MGB
- PAF
posterior auditory cortical area
- PH
parahippocampal cortex
- PO
lateral part of the posterior group of thalamic nuclei
- PU
putamen
- RE
reticular complex of thalamus
- rs
rhinal sulcus
- SG
suprageniculate nucleus of the dorsal division of the MGB
- ss
suprasylvian sulcus
- TMB
tetrametylbenzidine
- VBX
ventrobasal complex
- VLa
ventrolateral complex
- VL
ventro-lateral nucleus of the ventral division of the MGB
- WGA-HRP
wheat germ agglutinin conjugated to horse-radish peroxidase
- WM
white matter
- VPAF
ventro-posterior auditory cortical area 相似文献
42.
Analysis of human papillomavirus prevalence and TP53 polymorphism in head and neck squamous cell carcinomas 总被引:1,自引:0,他引:1
Cortezzi SS Provazzi PJ Sobrinho JS Mann-Prado JC Reis PM de Freitas SE Filho JF Fukuyama EE Cordeiro JA Cury PM Maniglia JV Villa LL Tajara EH Rahal P 《Cancer Genetics and Cytogenetics》2004,150(1):44-49
Head and neck squamous cell carcinoma is a disease associated with tobacco and alcohol abuse. There is evidence that the oncogenic human papillomavirus (HPV) may also be a risk for upper aerodigestive tract cancers. High-risk HPVs encode two early proteins, E6 and E7, that can bind to p53 and pRb, respectively, and induce its degradation or inactivation. The TP53 gene has a single polymorphism at codon 72 of exon 4 that encodes either arginine (Arg) or proline (Pro). The purpose of this study was to evaluate the role of HPV infection and TP53 polymorphism in head and neck cancer. We analyzed 50 tumors, as well swabs of oral mucosa from 142 control individuals, with a polymerase chain reaction technique. The prevalence of HPV in controls was 10.6% and in cancer specimens 16%. The frequency distribution of genotypes in controls was 50% Arg/Arg, 43% Arg/Pro and 7% Pro/Pro; in tumors, it was 52% Arg/Arg, 32% Arg/Pro, and 16% Pro/Pro. Contrary to the results of some studies on cervical cancer, no association between any TP53 genotype or allele and the development of head and neck cancer was observed, regardless of HPV status, except for the Pro/Pro genotype, which is associated with the absence of HPV. The arginine allele appears to protect against head and neck cancers. Also, the data showed that HPV infection results in no increased risk of developing head and neck tumors. 相似文献
43.
Genetic control of in vitro natural cell-mediated activity against Salmonella typhimurium by intestinal and splenic lymphoid cells in mice.
下载免费PDF全文
![点击此处可从《Clinical and experimental immunology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
In vitro natural anti-bacterial activity against Salmonella typhimurium by lymphocytes from Peyer's patches and spleens was assessed in several mouse strains. C3H/HeN and CBA/J mice, which are resistant to S. typhimurium infections, showed a natural anti-bacterial activity significantly higher than BALB/c, C57BL/10, C57BL/6 and C3H/HeJ mice, i.e. strains susceptible to the in vivo bacterial infection. In these susceptible strains and also in A/J mice, a significantly higher natural activity was observed in females compared to males. The sex control of natural anti-bacterial activity was further stressed by the fact that orchidectomy could induce a strong activity in low responder C57BL/10 male mice. With the exception of Beige mice, a low natural killer (NK) strain also with no natural activity against S. typhimurium in both sexes, the genetic distribution of natural anti-bacterial activity was extremely different from that of the NK activity. Thus, these results further stress the difference between natural anti-bacterial activity and NK cytotoxicity. Furthermore, our data establish a possible link, although with some exceptions, between in vivo susceptibility to S. typhimurium infections and in vitro natural activity against these bacteria. 相似文献
44.
45.
Speech suppression without aphasia after bilateral perisylvian softenings (bilateral rolandic operculum damage) 总被引:1,自引:0,他引:1
The authors describe a patient who suffered two successive, right and left, strokes that caused bilateral rolandic operculum damage. The clinical picture was characterized by selective impairment of volitional facio-pharyngo-glosso-masticatory movements with sparing of automatic and reflex motor activity (Foix-Chavany-Marie syndrome). Though completely speechless, the patient was not aphasic. This dissociation is discussed in the light of the peculiar localization of lesions evidenced by CT-scan.
Sommario Viene descritta una paziente portatrice di due lesioni ischemiche coinvolgenti l'opercolo rolandico in entrambi gli emisferi. Il quadro clinico era caratterizzato da una compromissione selettiva dei movimenti volontari (con integrità di quelli automatici e riflessi) bilateralmente a livello facio-faringo-glosso-masticatorio (sindrome di Foix-Chavany-Marie). La paziente, del tutto incapace di articolazione e fonazione, non risultava afasica ad una valutazione neuropsicologica. Questa dissociazione viene discussa in riferimento alla particolare localizzazione delle lesioni alla T.A.C. cerebrale.相似文献
46.
Chuyuan Wang Patricia Solís Lily Villa Nayan Khare Elizabeth A. Wentz Aaron Gettel 《Journal of urban health》2021,98(3):344
The objective of the present study was to examine the effects of a confluence of demographic, socioeconomic, housing, and environmental factors that systematically contribute to heat-related morbidity in Maricopa County, Arizona, from theoretical, empirical, and spatial perspectives. The present study utilized ordinary least squares (OLS) regression and multiscale geographically weighted regression (MGWR) to analyze health data, U.S. census data, and remotely sensed data. The results suggested that the MGWR model showed a significant improvement in goodness of fit over the OLS regression model, which implies that spatial heterogeneity is an essential factor that influences the relationship between these factors. Populations of people aged 65+, Hispanic people, disabled people, people who do not own vehicles, and housing occupancy rate have much stronger local effects than other variables. These findings can be used to inform and educate local residents, communities, stakeholders, city managers, and urban planners in their ongoing and extensive efforts to mitigate the negative impacts of extreme heat on human health in Maricopa County. 相似文献
47.
Persistent human papillomavirus infection as a predictor of cervical intraepithelial neoplasia. 总被引:35,自引:0,他引:35
N F Schlecht S Kulaga J Robitaille S Ferreira M Santos R A Miyamura E Duarte-Franco T E Rohan A Ferenczy L L Villa E L Franco 《JAMA》2001,286(24):3106-3114
CONTEXT: Human papillomavirus (HPV) infection is believed to be the central cause of cervical cancer, although most of the epidemiological evidence has come from retrospective, case-control studies, which do not provide information on the dynamics of cumulative or persistent exposure to HPV infection. OBJECTIVE: To assess the risks of cervical neoplasia related to prior persistent HPV infections. DESIGN AND SETTING: Longitudinal study of the natural history of HPV infection and cervical neoplasia in women residing in the city of S?o Paulo, Brazil, which was conducted between November 1993 and March 1997 and involved repeated measurements of HPV and lesions with follow-up until June 2000. PARTICIPANTS: A total of 1611 women with no cytological lesions at enrollment and HPV test results available from the first 2 visits. MAIN OUTCOME MEASURE: Cervical specimens taken for Papanicolaou cytology and HPV testing every 4 months in the first year and twice yearly thereafter. Incident cervical cancer precursor lesions ascertained by expert review of all cytology smears. RESULTS: The incidence rate of squamous intraepithelial lesions (SILs) was 0.73 per 1000 women-months (95% confidence interval [CI], 0.5-0.9) among women free of HPV at the 2 initial visits and 8.68 (95% CI, 2.3-15.1) among women with HPV type 16 or 18 infections persisting over both visits. Relative to those negative for HPV oncogenic types at both initial visits, the relative risk (RR) of incident SIL was 10.19 (95% CI, 5.9-17.6) for persistent infections with any known oncogenic HPV types. The equivalent RR of incident high-grade SIL was 11.67 (95% CI, 4.1-33.3). The RRs of lesions were considerably higher for persistent infections with HPV type 16 or 18. CONCLUSION: A strong relationship exists between persistent HPV infections and SIL incidence, particularly for HPV types 16 and 18. 相似文献
48.
49.
Rico H Roca-Botran C Hernández ER Seco C Paez E Valencia MJ Villa LF 《Menopause (New York, N.Y.)》2000,7(6):413-416
OBJECTIVE: The effect of a copper supplement on preventing bone mass loss induced by ovariectomy in rats was investigated. DESIGN: Three groups of fifteen 100-day-old female Wistar rats, each with a mean initial weight of approximately 260 g per animal, were selected for a 30-day experiment. One group of 15 ovariectomized rats was fed a diet supplemented with 15 mg of copper per kilogram of feed. The other two groups: 15 ovariectomized and 15 Sham- ovariectomized rats did not receive the supplement. Morphometric (weight and length) and densitometric studies with dual-energy x-ray absorptiometry were performed on the whole femur and the fifth lumbar vertebra of each animal at the end of the 30-day period. RESULTS: The ovariectomized rat group fed a diet supplemented with copper did not show the bone mass loss at the axial (fifth lumbar vertebra) or peripheral (femur) level that was evidenced in the ovariectomized group. CONCLUSIONS: The results of the measurement of axial and peripheral bones show that a supplement of copper may have a potential therapeutic application in the treatment and prevention of involutional osteoporosis. 相似文献
50.
Clerici M Salvi A Trabattoni D Lo Caputo S Semplici F Biasin M Ble C Meacci F Romeo C Piconi S Mazzotta F Villa ML Mazzoli S 《Immunology letters》1999,66(1-3):21-25
In a recent, thought-provoking novel by Elizabeth McCracken (The Giant's House. Avon Books, New York, 1997), two characters discuss love and its impossibilities. One brashly claims to be "immune to love", explaining the concept to his perplexed interlocutor, "...people become immune to love like they become immune to any disease. Either they had it bad early in life, like chicken pox and that's that; or they keep getting exposed to it in little doses and build up an immunity; or somehow they just don't catch it, something in'em is born resistant. I'm the last type. I'm immune to love and poison ivy". (p. 275) (E. McCracken, The Giant's House. Avon Books, New York, 1997). Substitute the words 'HIV infection' for 'love' and this intriguing metaphor summarizes the state of the art working hypotheses for the phenomenon of resistance to HIV infection in HIV-exposed individuals who, against all odds, do not seroconvert. These hypotheses will be discussed hereafter and particular emphasis will be placed upon a possible role for mucosal immunity in this phenomenon. 相似文献