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691.
Sabbir T. Rahman Mary Waterhouse Briony Duarte Romero Catherine Baxter Dallas R. English Osvaldo P. Almeida Michael Berk Peter R. Ebeling Bruce K. Armstrong Donald S. A. McLeod Gunter Hartel Rachel L. O’Connell Hai Pham James G. Scott Jolieke C. van der Pols Alison J. Venn Penelope M. Webb David C. Whiteman Rachel E. Neale 《International journal of geriatric psychiatry》2023,38(1):e5847
692.
693.
Objective. To determine whether chondrocytes in early experimental osteoarthritic (OA) cartilage continue to show increased synthesis and turnover of proteoglycans (PGs) during explant culture. A comparison was also made between the responsiveness of experimental OA and control cartilage to interleukin-1β (IL-1β) and tumor necrosis factor α (TNFα) after 1 day and 3 days in culture. Methods. OA was induced in mature animals by sectioning of the anterior cruciate ligament followed by 3 months of normal exercise. PG synthesis in the articular cartilage was determined by measuring 35S-sulfate incorporation during explant culture over 1–3 days. Inhibition of PG synthesis was also determined with various concentrations of IL-1β and TNFα after 1 and 3 days in culture. PGs extracted from the articular cartilage over 1–3 days in culture were examined by agarose–polyacrylamide gel electrophoresis. Results. Up to 24 hours after excision from the joint, PG synthesis was higher in experimental OA cartilage than in control cartilage. It was also less sensitive to inhibition by TNFα. These differences were no longer detected after 48–72 hours in culture. There were no changes in the relative proportions of aggrecan and decorin/biglycan extracted from and synthesized by control and experimental OA cartilage over the 3 days in culture. Conclusion. Previous results indicated that PG synthesis and turnover in articular cartilage was increased for many months after induction of experimental OA. Our present results show that the enhanced rate of PG synthesis and turnover were evident in freshly explanted tissue, but the differences were lost over 3 days in culture. A decreased responsiveness to TNFα was also lost. The hypermetabolic activity of experimental OA chondrocytes was thus reversible and not a permanent change in chondrocyte phenotype. 相似文献