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Raoul Orvieto Eran Zilberberg Valeria Stella Vanni Amnom Botchan 《Gynecological endocrinology》2018,34(7):551-553
We report for the first time on a case of infertile advance-age patient with large intramural fibroid, who conceived following a course of Ulipristal. The patient underwent two fresh fertility preserving IVF cycles, with cryopreservation of 9?day-3 embryos, followed by a 12?weeks course of Ulipristal (5?mg per day) and a subsequent frozen-thawed embryo transfer with her own previously cryopreserved embryos. We, therefore, believe that Ulipristal is a valuable addition to treatment armamentarium of advance-age infertile patient with prominent intramural fibroid. 相似文献
73.
Armando Perrotta MD PhD Natalia Arce‐Leal MD PhD Cristina Tassorelli MD PhD Valeria Gasperi PhD Grazia Sances MD Fabio Blandini MD PhD Mariano Serrao MD PhD Monica Bolla MD Francesco Pierelli MD DrMSc Giuseppe Nappi MD DrMSc Mauro Maccarrone DrMSc Giorgio Sandrini MD DrMSc 《Headache》2012,52(9):1350-1361
Objectives.— We investigated (1) a possible relationship between the functional activity of the endocannabinoid system and the facilitation of pain processing in migraineurs with medication‐overuse headache, and (2) the effect of withdrawal treatment on both. Background.— The endocannabinoid system antinociception effect includes prevention of nociceptive pathways sensitization. The sensitization of the pain pathways has been demonstrated to be pivotal in the development and maintenance of chronic form of migraine, including medication‐overuse headache. Methods.— We used the temporal summation threshold of the nociceptive withdrawal reflex to explore the spinal cord pain processing, and the platelet activity of the enzyme fatty acid amide hydrolase to detect the functional state of the endocannabinoid system in 27 medication‐overuse headache subjects before and 10 and 60 days after a standard withdrawal treatment and compared results with those of 14 controls. Results.— A significantly reduced temporal summation threshold and increased related pain sensation was found in subjects before withdrawal treatment when compared with controls. A significant fatty acid amide hydrolase activity reduction coupled with a significant improvement (reduction) in facilitation of spinal cord pain processing (increase in temporal summation threshold and reduction in related pain sensation) was found in medication‐overuse headache subjects at both 10 and 60 days after withdrawal treatment when compared with medication‐overuse headache subjects before withdrawal treatment. Conclusions.— We demonstrated a marked facilitation in spinal cord pain processing in medication‐overuse headache before withdrawal treatment when compared with controls. Furthermore, the acute reduction of the fatty acid amide hydrolase activity coupled with a reduction of the facilitation in pain processing immediately (10 days) after withdrawal treatment and its persistence 60 days after withdrawal treatment could represent the consequence of a mechanism devoted to acutely reduce the degradation of endocannabinoids and aimed to increase the activity of the endocannabinoid system that results in an antinociceptive effect. 相似文献
74.
A relaxometric method for the assessment of intestinal permeability based on the oral administration of gadolinium‐based MRI contrast agents
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Eliana Gianolio Cinzia Boffa Valeria Orecchia Paola Bardini Valeria Catanzaro Valeria Poli Silvio Aime 《NMR in biomedicine》2016,29(4):475-482
Herein, a new relaxometric method for the assessment of intestinal permeability based on the oral administration of clinically approved gadolinium (Gd)‐based MRI contrast agents (CAs) is proposed. The fast, easily performed and cheap measurement of the longitudinal water proton relaxation rate (R1) in urine reports the amount of paramagnetic probe that has escaped the gastrointestinal tract. The proposed method appears to be a compelling alternative to the available methods for the assessment of intestinal permeability. The method was tested on the murine model of dextran sulfate sodium (DSS)‐induced colitis in comparison with healthy mice. Three CAs were tested, namely ProHance®, MultiHance® and Magnevist®. Urine was collected for 24 h after the oral ingestion of the Gd‐containing CA at day 3–4 (severe damage stage) and day 8–9 (recovery stage) after treatment with DSS. The Gd content in urine measured by 1H relaxometry was confirmed by inductively coupled plasma‐mass spectrometry (ICP‐MS). The extent of urinary excretion was given as a percentage of excreted Gd over the total ingested dose. The method was validated by comparing the results obtained with the established methodology based on the lactulose/mannitol and sucralose tests. For ProHance and Magnevist, the excreted amounts in the severe stage of damage were 2.5–3 times higher than in control mice. At the recovery stage, no significant differences were observed with respect to healthy mice. Overall, a very good correlation with the lactulose/mannitol and sucralose results was obtained. In the case of MultiHance, the percentage of excreted Gd complex was not significantly different from that of control mice in either the severe or recovery stages. The difference from ProHance and Magnevist was explained on the basis of the (known) partial biliary excretion of MultiHance in mice. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
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Hiram Larangeira de Almeida Jr Debora Sarzi Sartori Janaína Kopp Carolina Dahmer Velloso Valeria Magalh?es Jorge 《Anais brasileiros de dermatologia》2013,88(4):620-622
Hydroa Vaciniforme is a very rare photodermatosis that is mainly seen in childhood.
An 18 year old female student reported that since the age of 5 she has been suffering
necrotic lesions and vesicles lesions in exposed areas, leaving asymptomatic
varioliform scars, which worsened in summer. Light microscopy showed epidermal
necrosis with lymphocytic infiltration. Sunscreens were prescribed with light
improvement. 相似文献
77.
Carmine Vitale Valeria Agosti Dario Avella Gabriella Santangelo Marianna Amboni Rosaria Rucco Paolo Barone Francesco Corato Giuseppe Sorrentino 《Neurological sciences》2012,33(6):1337-1343
The aim of the present study was to evaluate the effects of a Global Postural Rehabilitation (GPR) program on motor symptoms and gait parameters of patients with Parkinson’s disease (PD) by means of three-dimensional motion analysis study. Ten subjects with clinical diagnosis of PD were enrolled (study group). Age-, sex- and disease duration-matched PD patients were recruited as a control group (no treatment). Three-dimensional motion analysis was conducted by means of a stereophotogrammetric system. After basal evaluation, the study group underwent a specific rehabilitation program consisting of individual 40?min GPR daily sessions, 3?days a week for 4 consecutive weeks. Neurological status and spatiotemporal gait parameters of the two groups were evaluated at study entry (t 0), at 4?weeks (t 1, end of rehabilitation protocol) and at 8 and 12?weeks (t 2 and t 3, follow-up evaluation). At baseline evaluation, the two groups did not differ in clinical features and gait parameters. At the end of rehabilitation protocol (t 1) and at follow-up evaluation (t 2 and t 3), a significant improvement in temporal gait parameters and UPDRS scores was observed in all treated patients as compared to baseline and controls. Our preliminary findings showed that significant improvements in mobility and gait parameters of PD patients can be obtained through GPR treatment, with a parallel improvement in clinical status. Quantitative analysis of gait pattern can be considered a useful tool to assess the efficacy of rehabilitation interventions in patients affected by PD. 相似文献
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Massimiliano Cadamuro Simone Brivio Joachim Mertens Marta Vismara Anja Moncsek Chiara Milani Christian Fingas Maria Cristina Malerba Giorgia Nardo Luigi DallOlmo Eleonora Milani Valeria Mariotti Tommaso Stecca Marco Massani Carlo Spirli Romina Fiorotto Stefano Indraccolo Mario Strazzabosco Luca Fabris 《Journal of hepatology》2019,70(4):700-709