全文获取类型
收费全文 | 1530414篇 |
免费 | 94714篇 |
国内免费 | 1826篇 |
专业分类
耳鼻咽喉 | 20972篇 |
儿科学 | 48908篇 |
妇产科学 | 39582篇 |
基础医学 | 232736篇 |
口腔科学 | 40337篇 |
临床医学 | 137214篇 |
内科学 | 284995篇 |
皮肤病学 | 34350篇 |
神经病学 | 110515篇 |
特种医学 | 60004篇 |
外国民族医学 | 254篇 |
外科学 | 230542篇 |
综合类 | 28069篇 |
现状与发展 | 3篇 |
一般理论 | 360篇 |
预防医学 | 108378篇 |
眼科学 | 35093篇 |
药学 | 121387篇 |
8篇 | |
中国医学 | 3686篇 |
肿瘤学 | 89561篇 |
出版年
2018年 | 16116篇 |
2017年 | 12371篇 |
2016年 | 14155篇 |
2015年 | 15733篇 |
2014年 | 21308篇 |
2013年 | 31199篇 |
2012年 | 43913篇 |
2011年 | 47114篇 |
2010年 | 27535篇 |
2009年 | 25454篇 |
2008年 | 43451篇 |
2007年 | 47109篇 |
2006年 | 47269篇 |
2005年 | 45040篇 |
2004年 | 43398篇 |
2003年 | 41743篇 |
2002年 | 40262篇 |
2001年 | 78268篇 |
2000年 | 80218篇 |
1999年 | 66523篇 |
1998年 | 16893篇 |
1997年 | 14687篇 |
1996年 | 14694篇 |
1995年 | 13764篇 |
1994年 | 12425篇 |
1993年 | 11932篇 |
1992年 | 49851篇 |
1991年 | 49495篇 |
1990年 | 49121篇 |
1989年 | 47501篇 |
1988年 | 43047篇 |
1987年 | 42082篇 |
1986年 | 39402篇 |
1985年 | 37299篇 |
1984年 | 27200篇 |
1983年 | 23059篇 |
1982年 | 12406篇 |
1979年 | 24830篇 |
1978年 | 16965篇 |
1977年 | 14724篇 |
1976年 | 13617篇 |
1975年 | 15897篇 |
1974年 | 18230篇 |
1973年 | 17630篇 |
1972年 | 16638篇 |
1971年 | 15768篇 |
1970年 | 14580篇 |
1969年 | 13902篇 |
1968年 | 12585篇 |
1967年 | 11286篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
81.
OBJECTIVE: This study was conducted to compare an otolaryngologist's experience with a cohort of epilepsy patients implanted with a vagal nerve stimulator (VNS) to previously published data. METHODS: Demographics, preoperative seizure frequency, medications, and complications were retrospectively collected from patients implanted by the senior author. Postoperative medications and seizure frequency were obtained from referring neurologists. RESULTS: Seventeen patients were implanted over a 24-month period. Average age was 28.3 years. Patients presented with petit mal (n = 3), tonic-clonic (n = 6), complex partial (n = 5), and grand mal (n = 8) seizures. Mean follow-up postimplantation was 13.5 months. Most patients had at least a 50% reduction of seizure frequency, with 3 patients being seizure free. There were no postoperative infections. One patient had left vocal cord immobility. The most common side effect was voice disturbance during device activation. CONCLUSION: Otolaryngologists are well equipped to perform VNS implantation and to diagnose and treat possible laryngeal side effects. EBM rating: C-4. 相似文献
82.
Kevin L Taylor Rhonda K Oates Ron Grane Douglas W Leaman Ernest C Borden Daniel J Lindner 《Journal of interferon & cytokine research》2006,26(5):353-361
Interferon-alpha (IFN-alpha) has proved effective in the treatment of hemangiomas, hemangioblastomas, and Kaposi's sarcoma. To investigate the ability of IFNs to inhibit angiosarcoma, we used two transformed murine endothelial cell lines that form angiosarcomas in vivo. SVR and MS1-VEGF cell lines express oncogenic H-ras or vascular endothelial growth factor (VEGF), respectively. IFN-alpha1,8, which is active against murine and human cells, inhibited SVR and MS1-VEGF proliferation in vitro by 40% at 10(3) U/mL (p = 0.028). In vivo, IFN-alpha1,8 inhibited SVR tumor volume by 71% (p = 0.047) and MS1-VEGF volume by 79% (p = 0.003). Tumor-induced angiogenesis was decreased in SVR tumors by 52% (p = 0.005) and in MS1-VEGF tumors by 58% (p = 0.001). Sera from IFN-alpha1,8-treated mice bearing either SVR or MS1-VEGF tumors demonstrated a 5-fold increase in IP-10/CXCL10 (p = 0.001), an IFN-induced antiangiogenic protein. Both recombinant IP-10 and IFN-alpha1,8 inhibited human umbilical vein endothelial cell (HUVEC) vessel formation in the fibrin gel assay, a three-dimensional culture model of angiogenesis, by 56% at 25 ng/mL and 50% at 1.2 ng/mL, respectively (p < 0.001). An IP-10 blocking antibody restored vessel formation to 80% of untreated controls (p = 0.001). Given the magnitude of the in vivo response, these data suggested that the antitumor effects of IFN-alpha1,8 were likely mediated through angiogenesis inhibition rather than solely by direct inhibition of tumor cell proliferation. 相似文献
83.
S. V. Terent’eva E. N. Komarova T. N. Sapozhnikova A. T. Teplyakov E. A. Ivanovskaya T. I. Andreeva 《Pharmaceutical Chemistry Journal》2006,40(12):694-696
A rapid procedure for determining angiotensin II in the blood by inverse voltammetry using a TA-2 device (Tekhnoanalit Company,
Tomsk) with a graphite electrode has been developed. The results of analyses using the proposed technique agree with the clinical
data. The rapid analytical procedure favors optimization of cardiotropic drug therapy.
__________
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 12, pp. 54–56, December, 2006. 相似文献
84.
85.
Successful efforts in improving breastfeeding initiation rates at an urban teaching hospital prompted the hospital to create a lactation consultant (LC) position in the outpatient setting to focus on breastfeeding duration. This article reviews the complexity of the clinic setting, with the challenges and benefits of the consultant's first year in one of the hospital's outpatient clinics. Preliminary data collected by the consultant suggest that patients counseled by the LC in the outpatient clinic setting have longer breastfeeding duration rates. 相似文献
86.
M. RAUVALA K. AGLUND† U. PUISTOLA T. TURPEENNIEMI-HUJANEN‡ G. HORVATH§ R. WILLÉN & U. STENDAHL† 《International journal of gynecological cancer》2006,16(3):1297-1302
The incidence of uterine cervical cancer has increased slightly in Western countries, with an increase in relatively young women. Overexpression of matrix metalloproteinases (MMPs)-2 and -9 has turned out as a prognostic factor in many cancers. We compared the expression of the proteins MMP-2 and MMP-9 in cervical primary tumors with clinical outcome and risk factors of cervical cancer. One hundred sixty-one patients with cervical cancer treated in Ume? University Hospital or Sahlgrenska University Hospital, Sweden, between 1991 and 1995 were included in the study. Paraffin-embedded tissue samples obtained prior to treatment were examined immunohistochemically by specific antibodies for MMP-2 and MMP-9. Forty-two percent of the tumors were intensively positive for MMP-2 and 31% for MMP-9. Nineteen percent of the samples were intensively positive for both proteinases and 47% negative or weak for both. Overexpression of MMP-2 seemed to predict unfavorable survival under Kaplan-Meier analysis and in the multivariate analysis. Early sexual activity and low parity seemed to correlate to overexpression of MMP-2. MMP-9 was not associated with survival or sexual behavior. Intensive MMP-9 was noted in grade 1 tumors. We conclude that MMP-2 and MMP-9 have different roles in uterine cervical cancer. MMP-2 could be associated with aggressive behavior, but MMP-9 expression diminishes in high-grade tumors. 相似文献
87.
88.
Abstract: Background: Few studies have examined in depth the labor progression of multiparas to determine if there is any additional impact of being parous beyond the first birth. The objective of this study was to determine the effect of parity on labor progression in contemporary obstetric practice. Methods: Our sample consisted of all low‐risk women who delivered a term, live‐born infant from January 2002 to March 2004 at a single institution in Delaware, United States (n = 5,589). The median duration of labor by each centimeter of cervical dilation was computed for parity = 0 (n = 2,645); parity = 1 (n = 1,839); parity = 2 (n = 750); and parity = 3 + (n = 355). Results: Multiparas had a significantly faster labor progression from 4 to 10 cm (293, 300, and 313 min, respectively, for parity = 1, parity = 2, and parity = 3 +), compared with nulliparas (383 min for parity = 0), as well as a shorter second stage of labor. However, no significant differences were found in duration of the active phase or the second stage of labor among multiparas. Conclusions: Additional childbearing appears to have no effect of on the progression of labor among multiparous subgroups. The difference in duration of the active phase between nulliparas and multiparas is substantially smaller in a contemporary population. (BIRTH 33:1 March 2006) 相似文献
89.
90.
Elhaji Youssef A.; Stoica Ileana; Dennis Sheldon; Purisima Enrico O.; Lumbroso Rose; Beitel Lenore K.; Trifiro Mark A. 《Human molecular genetics》2006,15(9):1561
Human Molecular Genetics (2006) 15, 921931; 相似文献