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333.
Engelstad BL; Spitler LE; Del Rio MJ; Ramos EC; Rosendorf LL; Reinhold CE; Khentigan A; Huberty JP; Corpuz SW; Lee HM 《Radiology》1986,161(2):419-422
A phase 1 study was conducted using a monoclonal antimelanoma antibody-DTPA conjugate labeled with indium-111, for immunolymphoscintigraphy in patients with metastatic melanoma. The imaging agent, labeled with 1 mCi (37 MBq) In-111, was administered as an interstitial interdigital injection to six patients scheduled to undergo lymph node dissection for suspected metastatic malignant melanoma. No adverse effects were observed in any of the patients either during or after the infusion as determined by clinical and laboratory parameters. Antibodies to the murine immunoglobulin were produced in some patients. Regional lymph nodes were visualized whether tumor-bearing or not, and light microscopic autoradiography showed In-111 activity associated with histiocytes. One of two patients harboring both tumor-bearing and tumor-free lymph nodes exhibited preferential localization in tumor-bearing nodes. The authors conclude that this study demonstrates safety of the radiopharmaceutical and that further study is needed to improve its usefulness for diagnosis of lymph node metastases. 相似文献
334.
Kaufmann SJ; Eastaugh JL; Snowden S; Smye SW; Sharma V 《Human reproduction (Oxford, England)》1997,12(7):1454-1457
Infertility affects one in six couples at some time in their lives, with
48% of these couples requiring assisted conception techniques in order to
achieve a pregnancy. Whilst the overall clinical pregnancy rate per embryo
transfer is 23%, this varies widely between clinics. The Human
Fertilisation and Embryology Authority has attempted to analyse the results
of all units, with weighting of different factors affecting assisted
conception, and the published data have invariably led to comparisons
between units. However, statistical models need to be developed to
eliminate bias for valid comparisons. Neural networks offer a novel
approach to pattern recognition. In some instances neural networks can
identify a wider range of associations than other statistical techniques
due in part to their ability to recognize highly non-linear associations.
It was hoped that a neural network approach may be able to predict success
for individual couples about to undergo in-vitro fertilization (IVF)
treatment. A neural network was constructed using the variables of age,
number of eggs recovered, number of embryos transferred and whether there
was embryo freezing. Overall the network managed to achieve an accuracy of
59%.
相似文献
335.
Czervionke LF; Daniels DL; Ho PS; Yu SW; Pech P; Strandt J; Williams AL; Haughton VM 《Radiology》1988,169(3):753-759
Accurate diagnosis of diseases affecting the cervical neural foramina with magnetic resonance (MR) imaging requires an appreciation of the normal anatomic appearance of the foramen. The MR appearance of the foramen was studied in cadavers and healthy volunteers and was correlated with cadaver cryomicrotome sections. With gradient-echo techniques, foraminal soft tissues are highlighted relative to adjacent bone, making gradient-echo images valuable for evaluating the overall size and contents of the neural foramina. Intravenously administered gadolinium DTPA produces enhancement of all foraminal soft tissues, including the dorsal root ganglion. The nerve roots do not enhance with Gd-DTPA. Gradient-echo pulse sequences and intravenous use of Gd-DTPA represent promising techniques for the evaluation of the cervical foramina. 相似文献
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337.
抗肿瘤药物研究Ⅱ:去甲斑蝥素去氧脱氢类似物的合成与抗癌活性 总被引:57,自引:1,他引:56
In order to search for new compounds with higher anti-cancer activities and lower toxicities, 18 dehydrogenated carboncyclic analogs of norcantharidin, of which 17 are unknown compounds, were designed and synthesized. Preliminary screening results revealed that compound Ⅴ6, Ⅵ6 and Ⅵ4 exhibited fairly apparent inhibitory activity against the growth of human-hepatoma cells, Bei-7402, in vitro. The inhibitory rate of Ⅵ4 is 52%, almost the same as that of norcantharidin, in the concentration of 0.05 μmol/ml. 相似文献
338.
Assessment of nutritional status in CAPD patients: serum albumin is not a useful measure 总被引:4,自引:2,他引:2
Jones CH; Newstead CG; Will EJ; Smye SW; Davison AM 《Nephrology, dialysis, transplantation》1997,12(7):1406-1413
INTRODUCTION: In CAPD patients serum albumin is frequently used as an index
of nutritional status, although it is recognized that hypoalbuminaemia may
be caused by many factors. We have further examined the relationship
between serum albumin and nutrition. METHODS: Nutritional status was
assessed by biochemistry, anthropometry, mid-arm muscle circumference,
muscle strength (hand grip and back), and lean body mass (from
anthropometry, creatinine kinetics and bioimpedance) in a group of 76
stable CAPD patients. Correlations between biochemical and nutritional
parameters were sought and data were compared between patient groups
defined by serum albumin (> or = 37 vs < 37 g/l on two occasions 2
months apart) and separately according to subjective global assessment
score (normal nutrition, A vs mild to moderate, B, and severe, C,
malnutrition). RESULTS: In patients with a low SGA score, actual body
weight, body mass index, mid-arm muscle circumference, lean body mass,
subscapular skinfold thickness, hand grip strength (males and females) and
iliac and triceps skinfold thicknesses and back strength (females only)
were all significantly less than in patients with a normal SGA score. In
contrast, none of these variables differed in either gender when patients
were compared according to serum albumin. Serum albumin was correlated with
serum creatinine (r = 0.45, P = 0.01), daily urine protein excretion (r =
-0.42, P = 0.02) and uncorrected weekly creatinine clearance (r = -0.39) in
females, but not with any index of body composition in either gender.
CONCLUSION: Whilst SGA identified a patient group with significantly
abnormal body mass, muscle mass and muscle strength, serum albumin did not.
Serum albumin is not a useful marker of malnutrition in stable patients on
CAPD.
相似文献
339.
340.