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41.
Sara V. Tupak Thomas Dresler Meike Badewien Tim Hahn Lena H. Ernst Martin J. Herrmann Jürgen Deckert Ann‐Christine Ehlis Andreas J. Fallgatter 《Human brain mapping》2013,34(1):150-157
Recent studies highlighted the great potential of newly established theta burst stimulation (TBS) protocols for non‐invasive human brain stimulation studies using transcranial magnetic stimulation (TMS). While intermittent TBS over the primary motor cortex was found to potentiate motor evoked potentials, continuous TBS led to profound attenuations. Although numerous studies investigated the impact of TBS on motor cortex function, yet, only few imaging studies focused on its effects in other brain areas. Particularly for the prefrontal cortex, it is unclear whether TBS has similar effects compared to application over motor areas. In the current study continuous TBS was applied to either the left or right dorsolateral prefrontal cortex in a sample of healthy subjects. Changes in prefrontal oxygenation were measured during an emotional Stroop task by means of functional multi‐channel near‐infrared spectroscopy (fNIRS) before and after stimulation. Results showed bilaterally decreased prefrontal oxygenation following inhibitory stimulation of the left prefrontal cortex but no behavioral effect. No such alterations were observed following right‐hemispheric or sham stimulation. The results of the current study are in line with earlier findings and additionally demonstrate that also prefrontal oxygenation can be impaired by continuous TBS. Hum Brain Mapp, 2013. © 2011 Wiley Periodicals, Inc. 相似文献
42.
S Singh SV Gibikote S Sen A Korula IP Korah 《Journal of Medical Imaging and Radiation Oncology》1999,43(4):539-541
A case of hydatid disease of the lung proven by thoracotomy and histopathological evaluation is described. It was clinically and radiologically suggestive of a complicated pulmonary sequestration or non-resolving consolidation. 相似文献
43.
The present study has analysed the DNA adducts formed in SENCAR mouse
epidermis following topical application of 7-methylbenz[a]anthracene (7-
MBA). Mice were treated with 400 nmol of 7-MBA, which represents an
initiating dose of this hydrocarbon for SENCAR mice. DNA adducts were
analysed 24 h after topical application of the hydrocarbon by 32P-
postlabeling coupled with either HPLC analysis or an improved TLC procedure
giving better resolution of DNA adducts through the use of a D6 solvent
[isopropanol:4N NH4OH (1:1)] following D5. Twenty-four hours after topical
application of 400 nmol 7-MBA, the level of total covalent binding was 0.37
+/- 0.07 pmol/mg DNA as determined by 32P- postlabeling. This level of
binding correlated well with the relative tumor initiating activity of this
hydrocarbon compared to 7,12- dimethylbenz[a]anthracene (6.4 +/- 0.01
pmol/mg DNA) and dibenz[a,j]anthracene (0.03 +/- 0.01 pmol/mg DNA).
Analysis of the 32P- labeled 3',5'-diphosphodeoxyribonucleosides by HPLC
and TLC revealed the presence of deoxyguanosine (dGuo) and deoxyadenosine
(dAdo) adducts formed from both the anti- and syn-bay-region diol-epoxides
of 7-MBA (anti- and syn-7-MBADEs). The major DNA adduct derived from 7-MBA
in mouse epidermis was tentatively identified as (+) anti-7-MBADE-trans-N2-
dGuo. In addition, a minor dGuo adduct derived from the bay-region syn-
diol-epoxide of 7-MBA was detected as well as a minor dAdo adduct from this
diol-epoxide. Another minor dAdo adduct was also detectably present which
arose from either the anti- or syn-diol epoxide. Furthermore, several
unidentified DNA adducts were present in both HPLC and TLC chromatograms of
DNA samples from 7-MBA-treated mice. These results are discussed in terms
of the role of specific 7-MBA-DNA adducts in tumor initiation by this
hydrocarbon.
相似文献
44.
Intercalary bone allografts: radiographic evaluation 总被引:2,自引:0,他引:2
45.
Giant cell tumor of bone: radiographic changes following local excision and allograft replacement 总被引:1,自引:0,他引:1
The authors retrospectively evaluated the clinical records and radiographs obtained from 41 patients who had giant cell tumor of bone and who were treated by local resection and allograft replacement. Postoperative complications developed in 41% of the patients. However, the eventual clinical outcome was considered to be satisfactory in 85% of all cases. There were no instances of tumor recurrence, and surprisingly, postoperative arthritis was not a major problem. The major complications encountered were infection and allograft fracture; bone infection accounted for most of the clinical failures. All infections were associated with the increasing soft-tissue swelling and bone resorption detected on radiographic studies. Other radiographic parameters that were associated with an increased rate of complications included osteopenia, increased periosteal reaction, and decreased bone formation at the host-donor junction site. The clinical outcome was distinctly less favorable in those cases in which the patient had had a pathologic fracture or a previous resection, or in whom the graft was implanted at the distal radius. 相似文献
46.
47.
Hartimath SV Draghiciu O. Daemen T Nijman H.W. van Waarde A. Dierckx R.A.J.O. de Vries E.F.J. 《Molecular imaging and biology》2020,22(4):883-890
Molecular Imaging and Biology - Chemokine CXCL12 and its receptor CXCR4 are constitutively overexpressed in human cancers. The CXCL12-CXCR4 signaling axis plays an important role in tumor... 相似文献
48.
49.
Bakhai A Booth J Delahunty N Nugara F Clayton T McNeill J Davies SW Cumberland DC Stables RH;SV Stent Investigators 《International journal of cardiology》2005,102(1):95-102
OBJECTIVE: To evaluate the use of the phosphorylcholine (PC) coated BiodivYsio small vessel (SV) stent in native coronary vessels of small calibre. DESIGN AND SETTING: Prospective, multi-centre, multi-national registry with 6-month clinical and core-lab angiographic follow-up. Adverse events were adjudicated by a Clinical Events Committee (CEC) and included peri-procedural analysis of cardiac enzymes. PATIENTS: Patients with signs or symptoms of ischaemia with an identified target lesion in an epicardial vessel with reference diameter 2.0-2.75 mm were enrolled. Intervention in other epicardial territories in the same patient was permitted. RESULTS: Recruitment of 150 consecutive lesions (in 143 patients) was completed in 19 centres in Europe and Israel. The stent was deployed successfully in all but one lesion. At 6 months, 1 patient (1%) had experienced sudden cardiac death, 4 further patients (3%) had a non-Q wave MI, and a further 24 patients (17%) had repeat revascularisation of a study target vessel. The mean reference vessel diameter prior to stenting was 2.2 mm (S.D. 0.4). Mean minimal luminal diameters at pre-procedure, post procedure and follow-up were 0.6 mm (S.D. 0.3), 2.0 mm (S.D. 0.4) and 1.2 mm (S.D. 0.6), respectively. The late lumen loss index was 0.55 (S.D. 0.53) with a binary restenosis rate of 32%. CONCLUSIONS: In stenting of selected lesions in small vessels, the BiodivYsio SV stent demonstrated high rates of implant success. The rates of major adverse cardiac events (MACE), angiographic restenosis and repeat revascularisation are similar to those reported in other small vessel bare metal stent studies. 相似文献
50.