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S. Gardes M. Hellot S. Tringali J.-P. Larbre F. Biron G. Llorca R. Girard 《Médecine et maladies infectieuses》2010
The nasal septoplasty is a very current intervention in otorhinolaryngology surgery. The infectious complications of this intervention are rare and mostly mild. We report here the case of a patient hospitalized in ambulatory surgery within a fracture of the nose with luxation of the septum in the nasal fossa. This patient was operated for a reduction of this fracture with septoplasty. Twelve hours after the intervention the patient presented septic arthritis due to Streptococcus pyogenes. The tracks of prevention are presented. 相似文献
54.
Type II focal cortical dysplasia: Ex vivo 7T magnetic resonance imaging abnormalities and histopathological comparisons
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Ileana Zucca PhD Gloria Milesi PhD Valentina Medici PhD Laura Tassi MD Giuseppe Didato MD Francesco Cardinale MD Giovanni Tringali MD Nadia Colombo MD Manuela Bramerio MD Ludovico D'Incerti MD Elena Freri MD Michela Morbin MD Valeria Fugnanesi MSc Matteo Figini PhD Roberto Spreafico MD PhD Rita Garbelli PhD 《Annals of neurology》2016,79(1):42-58
55.
Maria Musumeci Gianluca Vadalà Giovanni Tringali Elio Insirello Anna Maria Roccazzello Jacques Simpore Salvatore Musumeci 《Journal of bone and mineral metabolism》2009,27(4):424-434
The aim of this study was to determine the prevalence of known gene polymorphisms associated with osteoporosis in postmenopausal
normal women from Burkina Faso and Sicily, compared to postmenopausal Sicilian women with osteoporosis, and to establish the
weight of environmental factors in the mechanism of osteoporosis. Bone mass density (BMD) was measured by phalangeal quantitative
ultrasound (QUS) in Burkinabe woman and by the dual X-ray absorptiometry at the femoral neck in Sicilian women. The polymorphisms
of the vitamin D receptor (VDR) gene, estrogen receptor (ESR) gene, calcitonin receptor (CTR) gene and COL1A1 collagen gene
were characterized by PCR. The social characteristics of studied women were evaluated by a specific questionnaire. The observed
percentages of single specific polymorphisms did not differ from that expected with exception of VDR B allele and ESR X and
P allele in Burkinabe and Sicilian women, respectively. Association analyses and multivariate two-step regression model of
social and molecular parameters, demonstrated that in comparison to the VDR, ESR, CTR polymorphisms, physical activities and
healthy diet, associated with outdoor work are the best favourable prognostic factors for osteoporosis. A diet rich in calcium,
other minerals and vitamin D in association with physical activity represents the most effective way to maintain not only
a healthy bone structure but also an acceptable BMD. This is particularly true for Sub-Saharan women. 相似文献
56.
Konstantin Svechnikov Carmela Spatafora Irina Svechnikova Corrado Tringali Olle Söder 《Journal of applied toxicology : JAT》2009,29(8):673-680
Resveratrol and its analogs are considered to be a promising drug candidate for treatment of cancer and different age‐associated diseases. In the present study we have investigated the effects of resveratrol and its synthetic analogs on steroidogenesis and mitochondrial function in primary cultures of rat Leydig cells. Our findings indicate that resveratrol and its analogs structure‐dependently attenuated hCG‐activated steroidogenesis in Leydig cells through suppression of the expression of steroidogenic acute regulatory protein and cytochrome P450c17. 3,5‐Diacetyl resveratrol was observed to modulate mitochondrial function in Leydig cells, suppressing polarization of inner mitochondrial membrane, and 3,4,4′‐trimethoxystilbene stimulated the overall activity of intracellular reductases involved in the reduction of WST‐1 to formazan. Thus, the inhibitory actions of resveratrol analogs on steroidogenesis in Leydig cells indicate novel mechanisms of action of these compounds, which may be of potential therapeutic interest, where suppression of androgen action is needed. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
57.
Alessandro Capuano Alice De Corato Mariangela Treglia Giuseppe Tringali Diego Currò Cinzia Dello Russo Pierluigi Navarra 《Neuropharmacology》2010,58(4-5):784-792
Naloxone has been used to antagonize opioid effects for many years, even though at low doses it can exert antinociceptive effects. This ‘paradoxical’ analgesia has been detected after systemic administration of naloxone given alone or in combination with opioid drugs. In the present study, we investigated possible peripheral antinociceptive effects of low doses of naloxone using both an in vivo and in vitro model of trigeminal nociception. Low doses of naloxone injected locally into the rat wiskerpad elicited antinociceptive activity in the rat orofacial formalin test. The block of primary afferents with local administration of capsaicin suggested that naloxone acts both directly on sensory neurons and indirectly, by modulating the inflammatory component of the second phase of formalin test. Naloxone analgesia is maintained in rats made tolerant to the μ-receptor agonist DAMGO, suggesting the involvement of δ- and κ-opioid receptors. Subsequently, the effects of very low doses of naloxone were tested in primary cultures of rat trigeminal neurons activated with bradykinin, in order to elucidate the mechanisms of action underlying naloxone antinociceptive effects. Naloxone inhibited bradykinin-evoked CGRP release in two different experimental paradigms, i.e. primed and unprimed cultures, acting at the level of δ- and κ-opioids receptors. These results suggest that low doses of naloxone can directly modulate the activation of the trigeminal neurons by modulating the activity of specific opioid receptors, and this effect may be clinically relevant in combined therapies where an increased analgesic effect is sought through the potentiation of peripheral mechanisms. 相似文献
58.
59.
Graziani G Tentori L Muzi A Vergati M Tringali G Pozzoli G Navarra P 《Molecular and cellular endocrinology》2007,264(1-2):44-49
It has been previously shown that corticotropin-releasing hormone (CRH) exerts antiproliferative activity on an estrogen-dependent tumor cell line, i.e. human endometrial adenocarcinoma Ishikawa (IK) cells. Here we have investigated the effects of CRH on another estrogen-dependent tumor cell line, human breast cancer MCF7 cells. In this paradigm, CRH given at a fixed concentration of 100 nM significantly inhibited cell growth induced by 100 nM estradiol (E2) after 48 and 72 h of incubation. This effect was not associated with the induction of apoptosis. CRH inhibition of cell proliferation was counteracted in a concentration-dependent manner by the non-selective CRH receptor antagonist, astressin, as well as by a CRH-R1 selective receptor antagonist, antalarmin. RNase protection assays carried out on MCF7 under basal conditions showed that these cells express in a constitutive manner the CRH-R1 receptor subtype. We have also investigated the putative source of CRH acting on breast cancer cells; we found that MCF7 cells express CRH mRNA under basal conditions and secrete sizable amounts of immunoreactive CRH, which leads to postulate the existence of paracrine-autocrine inhibitory mechanism operated by CRH in breast cancer cells. 相似文献
60.
P. Ferroli F. Acerbi G. Tringali G. Polvani E. Parati G. Broggi 《Acta neurochirurgica》2009,151(8):969-976
Purpose To report experience on the use of self-closing nitinol U-Clips for different types of intracranial arterial microanastomosis.
Methods We treated 7 patients (3 females and 4 males, age ranging from 25 to 68 yo) admitted from November 2005 to January 2008 to
the Neurological Institute C. Besta of Milan. One patient had cerebral hypoperfusion and the others a complex intracranial
aneurysm. In each patient a bypass procedure was completed by using self-closing Nitinol U-Clips for intracranial arterial
microanastomoses.
Results The total time of temporary occlusion was 15.71 ± 4.386 min. Bypass patency was confirmed intraoperatively by near-infrared
indocyanine green videoangiography and microdoppler in each patient. No spasm of the graft was encountered and immediate post-operative
bypass patency was confirmed in 6/7 patients. The graft thrombosed in 1 patient with antiphospholipid syndrome. 1 patient
died from a massive Subarachnoid Hemorrhage due to rupture of an aneurysm while waiting for an endovascular procedure. In
the 5 patients at the last follow-up, long-term patency of the bypass was confirmed and no neurological deficits occurred
related to the procedure.
Conclusion This is the first report of the use of U-Clips for intracranial microanastomosis. Our data indicated that it is a safe technique,
reduces the time taken to perform an anastomosis and the risk of an ischemic complication. Further studies of the longer-term
patency of bypass as performed with U-Clips are required.
P. Ferroli and F. Acerbi equally contributed to the paper. 相似文献