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101.
Koichiro Irie Takaaki Tomofuji Daisuke Ekuni Yasumasa Endo Kenta Kasuyama Tetsuji Azuma Naofumi Tamaki Toshiki Yoneda Manabu Morita 《Archives of oral biology》2014
Objective
Previous studies have demonstrated the relationship between ageing and oxidative stress. In this study, we examined the effects of topical application of a dentifrice containing anti-oxidative, anti-inflammatory, and anti-bacterial agents (Tomarina®) to the gingival surface on gingival collagen degradation in rats.Design
Fischer 344 male rats (4 or 8 months old) were divided into two groups: experimental group and control group. Tomarina® (the experimental group) or control dentifrice (the control group) was applied 5 days per week for 2 months.Results
In the control group, gingival collagen density decreased with ageing. In the experimental group, the collagen density did not change with ageing, and was greater than that in the control group at 10 months of age (p < 0.0083). In addition, the control group showed an increase in serum oxidative stress with ageing. The experimental group also showed increased serum oxidative stress, but the value was lower than the control group at 10 months of age (p < 0.0083). Furthermore, low expressions of protein oxidative damage in the periodontal tissue were observed in the experimental group, compared to the control group at 6 months and 10 months.Conclusion
These findings indicate that Tomarina® might suppress the effects of ageing on gingival collagen degradation, by decreasing oxidative stress in the rat model. 相似文献102.
Matsuura T Takehara Y Kaijima H Teramoto S Kato O 《Journal of assisted reproduction and genetics》2008,25(4):163-167
Purpose Although many reports support stimulated in vitro fertilization, several patients do not respond to it well. Furthermore,
stimulated treatment could be associated with reduced ovarian response. We describe three successful cases involving patients
of advanced age from whom dominant follicles were retrieved during the natural cycle.
Materials and methods All patients had failed to bear children through stimulated in vitro fertilization. In case 1, a follicle was retrieved after
a gonadotropin-releasing hormone agonist was used to induce luteinizing hormone surge. In cases 2 and 3, pregnancy was achieved
via completely natural cycles.
Results One embryo was transferred every 16 cycles. Ongoing pregnancy—defined as pregnancy progressing beyond gestation week 9—was
established in three cycles. The patients successfully delivered and had uneventful neonatal courses.
Conclusion Mature oocyte retrieval followed by natural rather than stimulated in vitro fertilization might be a potential treatment for
patients of advanced age when stimulated in vitro fertilization has been repeatedly unsuccessful.
Capsule We describe three successful pregnancies and deliveries achieved via natural IVF cycles: the patients were older than 37 years
with repeated failures by stimulated IVF. 相似文献
103.
Yasutomo Nagasue Takashi Akiyoshi Masashi Ueno Yosuke Fukunaga Satoshi Nagayama Yoshiya Fujimoto Tsuyoshi Konishi Toshiya Nagasaki Jun Nagata Toshiki Mukai Atsushi Ikeda Riki Ono Toshiharu Yamaguchi 《Journal of gastrointestinal surgery》2013,17(7):1299-1305
Background
The role of laparoscopic surgery for locally advanced colorectal cancer invading or adhering to neighboring organs is controversial. This study evaluated the safety and feasibility of laparoscopic multivisceral resection for colorectal cancer.Methods
This study included 126 patients who underwent multivisceral resection for primary colorectal cancer invading or adhering to neighboring organs or structures between July 2005 and November 2012 at our institution. Perioperative outcomes were compared between laparoscopic and open resections.Results
Laparoscopic and open multivisceral resections were performed in 60 and 66 patients, respectively. Conversion to open surgery occurred in 6.7 % of patients. The median operative time was significantly longer (271 vs. 227 min), but the median blood loss was significantly less (40 vs. 205 mL), in the laparoscopic compared with the open group. The R0 resection rate of the primary tumor (95 vs. 98.5 %), number of lymph nodes harvested (18 vs. 18), and postoperative complications (28 vs. 24 %) were comparable between the groups. The median length of hospital stay was significantly shorter (13.5 vs. 18 days) in the laparoscopic compared with the open group.Conclusions
Laparoscopic multivisceral resection for colorectal cancer invading or adhering to neighboring organs is safe and feasible in selected patients. 相似文献104.
105.
Ako E Morisaki T Hasegawa T Hirakawa T Tachimori A Nakazawa K Yamagata S Kanehara I Nishimura S Taenaka N 《Surgical laparoscopy, endoscopy & percutaneous techniques》2010,20(6):e226-e229
Intussusception is rare in adults and it is difficult to diagnose on admission. We present the case of a 43-year-old woman with the chief complaint of nausea and upper abdominal pain. Abdominal multidetector-row computed tomography showed ileo-ileal small bowel intussusception with an intraluminal soft tissue mass with attenuation numbers suggestive of a lipoma. The patient was treated with a laparoscopic-assisted extracorporeal partial resection of the small bowel including ileal lipoma, followed by a functional end-to-end anastomosis. Histologic diagnosis of the resected tumor, 2.4×2.0×2.0 cm, was an intestinal lipoma. This case serves as the basis of a review of small bowel intussusception in adults secondary to lipomas. It focuses on the utility of multidetector-row computed tomography and the cosmetic, physical, and economic benefits of laparoscopic surgery as well as the rarity of the disease. 相似文献
106.
107.
Kyoko Itoh Takashi Kasai Yukiko Tsuji Kozo Saito Ikuko Mizuta Yoshinori Harada Shinji Sudoh Toshiki Mizuno Masanori Nakagawa Shinji Fushiki 《Neuropathology》2014,34(3):309-313
Multiple system atrophy (MSA) is an oligodendrogliopathy of presumably sporadic origin, characterized by prominent α‐synuclein inclusions with neuronal multisystem degeneration, although a few Mendelian pedigrees have been reported. Here we report two familial cases of MSA of unknown genetic background. One patient was diagnosed as a possible MSA‐C (cerebellar dysfuntion) case, and the other as clinically possible MSA‐P (parkinsonism), which turned out to be definite MSA, based on a detailed autopsy. The neuropathology showed extensive deposition of α‐synuclein in the glia as well as in the neurons located in the cerebral cortices and hippocampal systems, although neither multiplication of the SNCA gene or mutations in COQ2 gene were identified in the family concerned. 相似文献
108.
Yoshihide Kanno MD Dai Hirasawa MD Naotaka Fujita MD Yutaka Noda MD Go Kobayashi MD Kazuhiko Ishida MD Kei Ito MD Takashi Obana MD Takashi Suzuki MD Toshiki Sugawara MD Jun Horaguchi MD Osamu Takasawa MD Kazunari Nakahara MD Tetsuya Ohira MD Kengo Onochi MD Yoshihiro Harada MD Wataru Iwai MD Masatake Kuroha MD 《Gastrointestinal endoscopy》2009,69(7):1363-1368
109.
Masaaki Morino M.D. Kiyoshi Inami M.D. Toshiki Kobayashi M.D. Kurumi Yanagisawa M.D. Kazuichi Maeda M.D. 《Pediatrics international》1991,33(1):93-98
Two sisters with acute tubulointerstitial nephritis (ATIN) are reported. The elder sister had concomitant uveitis which recurred twice. The younger sister became ill five years after the onset in the elder. Both patients had identical HLA haplotypes and also suffered from mild chronic sialoadenitis. A renal biopsy specimen of the elder sister showed not only marked interstitial infiltration of immunoglobulin-containing mononuclear cells but also immune-complex-related glomerulonephritis. The younger sister had immune complexes in the serum. These findings suggest that glomerulonephritis and uveitis may be secondary phenomena of ATIN with participation of circulating immune complexes. Once the uveal involvement has occurred, uveitis may undergo relapses without any renal manifestations. 相似文献
110.
Fujii H Iwai T Ueda Y Nakagawa H 《[Rinshō ketsueki] The Japanese journal of clinical hematology》2002,43(6):482-487
A 29-year-old male was diagnosed as having non-Hodgkin's lymphoma (NHL, diffuse, large cell, B-cell, stage IV) in June 1999. He underwent 7 courses of chemotherapy and double autologous peripheral stem cell transplantation (total dose: CPA 13,000 mg, BUS 892 mg, L-PAM 150 mg, MCNU 870 mg, MTX 60 mg, Ara-C 160 mg, DXR 350 mg, VP-16 11,190 mg, VCR 8 mg, CBDCA 700 mg, and MIT 22 mg) for NHL and obtained complete remission in April 2000. In September 2000, he suffered from progressive general malaise. Laboratory findings showed marked leukocytosis with 85% leukemia cells, which were positive for alpha-naphthyl butyrate esterase. Surface-marker analysis of the leukemia cells showed positive results for CD11b, CD11c, CD13, CD15, CD33, CD56, CD64, CD65, CD71 and HLA-DR, and chromosomal analysis revealed add(8) (p11), add(9) (p13). He was diagnosed as having AML (M5a) and was still in complete remission for NHL. He did not respond to chemotherapy and died in December 2000, believed to be from therapy-related leukemia induced by the VP-16 used for treating NHL, judging by the patient's short clinical course and monocytic type of leukemia. 相似文献