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71.
Colchicine for recurrent pericarditis in children 总被引:4,自引:0,他引:4
The incidence of recurrence of acute pericarditis in children varies from 15% to 30% and is accompanied by a high morbidity. Various treatment modalities have been used with variable success rates and side effects. La Serna et al. (Lancet 1987; 26: 1517) were the first to treat adults with recurrent pericarditis with colchicine, and were followed by other authors. To our knowledge no studies in children have been reported. In this paper, we present three children who suffered from viral or idiopathic recurrent pericarditis, despite multiple courses of non-steroidal anti-inflammatory drugs (NSAIDs) and/or corticosteroids. They responded remarkably well to colchicine, which was administered for 6 months with no adverse reactions. They continue to do well 18, 11 and 12 months after cessation of treatment, respectively. 相似文献
72.
Induced drug resistance inhibits selection of initiated cells and cancer development 总被引:1,自引:1,他引:0
Compounds exerting a mitoinhibitory effect on normal hepatocytes are potent
promoters in the resistant hepatocyte model of chemical carcinogenesis in
combination with stimulation of regenerative growth by partial hepatectomy
or treatment with carbon tetrachloride. 2- Acetylaminofluorene (2-AAF)
almost completely inhibits liver cell regeneration after partial
hepatectomy, allowing only resistant cells to participate in regenerative
growth. After initiation by diethylnitrosamine and promotion with 2-AAF and
partial hepatectomy (PH), focal growth of initiated cells generates liver
lesions which occupy 40% of the hepatic volume three weeks after PH. In
this work the mechanism for the anti promoting effects of phenobarbital and
3- methylcholantrene were investigated as well as their effects on the
development of malignant hepatocellular carcinoma in the resistant
hepatocyte model. Treatment with phenobarbital or, especially, 3-
methylcholanthrene rendered normal rat hepatocytes resistant to the
mitoinhibitory effect of 2-AAF. In combination with 2-AAF/PH, 3-
methylcholanthrene shortened the regenerative growth period to less than
one week. In the Solt-Farber protocol for experimental
hepatocarcinogenesis, treatment with phenobarbital or 3- methylcholanthrene
during promotion with 2-AAF/PH permitted hepatocytes surrounding the focal
lesions to respond with regenerative growth. The foci and surrounding liver
grew until the liver/body mass index reached the control value. With
phenobarbital treatment the total focal volume was 20% of the liver volume
three weeks after PH, whereas the corresponding value in the case of
3-methylcholanthrene was only 1%. Labelling index data supported the
conclusion that growth of the liver lesions in the resistant hepatocyte
model was dependent on differential inhibition of normal hepatocyte growth
by the promoter and that the size of the foci obtained was related to the
length of time after PH required to complete liver regeneration.
3-methylcholanthrene induced 2- AAF resistance prevented the development of
large persistent nodules and hepatocellular carcinoma while phenobarbital
delayed cancer development with several month. The data thus supports the
idea that the degree of clonal expansion during promotion determines the
size of the population at risk for malignant transformation, as well as the
final frequency of carcinomas.
相似文献
73.
74.
Giselle C. Medeiros Luiz C. S. Thuler Anke Bergmann 《Health & social care in the community》2021,29(6):1769-1778
This objective this study was to identify the time interval between breast cancer (BC) diagnosis and treatment initiation and delay-associated factors. This is a prospective cohort study that followed breast cancer patients, enrolled and treated at the cancer center in Rio de Janeiro (RJ) – Brazil, from October 02, 2014 to April 30, 2015. Participants were interviewed at the first consultation. Treatment-related information was collected six months after recruitment. The median and interquartile range (IQR) were calculated. The interval between breast cancer diagnosis and treatment initiation of more than 60 days was considered the delay, according to the maximum term determined by Brazilian law. The association between independent variables and the outcome was performed using the crude odds ratios (OR). Variables presenting p < .20 in the univariate analysis were included in the multiple logistic regression model by the stepwise forward method, and those with p < .05 were retained in the final model. A total of 470 patients were included in the study. The median time was of 127 days (IQR: 85– 174). Delay was observed in 89.1% of the cases. After adjustment, the variables associated with delay were age ≥ 60 years (OR: 2.48; 95% CI 1.22–5.06), initial clinical staging (<2B) (OR: 2.01; 95% CI 1.05–3.86) and residence outside the city of Rio de Janeiro (OR: 2.75; 95% CI 1.38–5.51). Delays in starting treatment were associated with sociodemographic and clinical factors. Improving patient quality of care and restructuring the health service can minimise delays. 相似文献
75.
0 引言 东方人接受皮肤磨削术治疗后色素沉着的发生率明显高于西方人.尽管采用了目前被认为是最适宜亚洲人的铒激光治疗,色素沉着仍可发生.因此,在实施该手术治疗前应严格掌握适应证,制定严密的预防治疗措施,使得色素沉着的发生率降至最低,从而最大限度的防止医疗纠纷的发生.1 对象和方法1.1 对象 21例患者,男2例,女19例,平均年龄29.2(08~48)岁.皱纹祛除8例,浅表疤痕7例,浅咖啡斑、黑子5例,不良纹眉1例.铒激光其它适应证:①老年斑;②细小皱纹;③“白皮肤”雀斑;④痤疮后疤痕⑤色素减退… 相似文献
76.
Inhaled dry powder mannitol in children with cystic fibrosis: A randomised efficacy and safety trial
K De Boeck E Haarman J Hull LC Lands A Moeller A Munck J Riethmüller H Tiddens S Volpi J Leadbetter B Charlton A Malfroot 《Journal of cystic fibrosis》2017,16(3):380-387
Introduction
Inhaled mannitol has beneficial effects on lung function, mucociliary clearance, quality of life and sputum properties. This trial examined the efficacy of inhaled mannitol in children with cystic fibrosis (CF).Methods
The efficacy of inhaled mannitol in children with CF aged 6–17 years was assessed in a phase 2, randomised, placebo-controlled crossover study. Subjects were randomly assigned to mannitol 400 mg every 12 h or matching placebo for 8 weeks, followed by an 8 week washout and an 8 week period with the alternate treatment. The primary endpoint was the absolute change from baseline in ppFEV1 (percent predicted FEV1).Results
A total of 92 subjects were studied, with a mean age of 12 years and mean baseline ppFEV1 of 72.2%. During mannitol treatment ppFEV1 was 3.42% (p = 0.004) higher compared to placebo or a 4.97% (p = 0.005) relative difference; relative change from baseline FEF25-75 was 10.52% (p = 0.013). During mannitol treatment, acute post-treatment sputum weight was higher (p = 0.012). In pre-specified subgroups (rhDNase use, age, and disease severity), the treatment differences consistently favoured mannitol. The most common AEs were cough and pulmonary exacerbations. Pulmonary exacerbation AEs were approximately 30% lower in the mannitol group.Conclusions
In children with CF, inhaled mannitol was associated with significant improvements in lung function and sputum weight, irrespective of rhDNase use, age or disease severity. Inhaled mannitol was well tolerated and was associated with a reduced incidence of pulmonary exacerbation AEs. (Clinical Trials.Gov: NCT 01883531) 相似文献77.
78.
JML White† EM Higgins‡ LC Fuller‡ 《Journal of the European Academy of Dermatology and Venereology》2007,21(8):1061-1064
BACKGROUND: There is currently an epidemic of tinea capitis in urban areas of developed countries caused by Trichophyton tonsurans. Recurrence or re-infection with dermatophyte is not uncommon after adequate oral treatment. Asymptomatic carriers who are household contacts may partly explain this observation by forming a reservoir for infection. PATIENTS/METHODS: Two-hundred and nine household contacts of patients with tinea capitis were examined and screened for asymptomatic carriage of dermatophyte. RESULTS: Only 7.2% had clinically evident disease yet 44.5% had silent fungal carriage on the scalp. Children under 16 years were much more likely to be carriers than adults (P < 0.001) and males were less likely than females to be affected (P < 0.01). CONCLUSION: This evidence poses questions about factors relevant in transmission of dermatophytes. The authors propose that all household contacts of patients with tinea capitis should be offered screening to eradicate a potential reservoir of infection. 相似文献
79.
Pedro Luiz Serrano Uson Junior Raphael LC Araujo 《World journal of gastrointestinal oncology》2022,14(8):1446-1455
Bile duct tumors are comprised of tumors that originate from both intrahepatic and extrahepatic bile ducts and gallbladder tumors. These are aggressive tumors and chemotherapy is still the main treatment for advanced-stage disease and most of these cases have a poor overall survival. Strategies are aimed at treatments with better outcomes and less toxicity which makes immunotherapy an area of significant importance. Recent Food and Drug Administration approvals of immune checkpoint inhibitors (ICI) for agnostic tumors based on biomarkers such as microsatellite instability-high and tumor mutation burden-high are important steps in the treatment of patients with advanced bile duct tumors. Despite limited responses with isolated checkpoint inhibitors in later lines of systemic treatment in advanced disease, drug combination strategies have been demonstrating encouraging results to enhance ICI efficacy. 相似文献
80.
PA Kowacs EJ Piovesan CE Tatsui MC Lange LC Ribas LC Werneck 《Cephalalgia : an international journal of headache》1999,19(4):241-242
The case of a 42-year-old woman with prolonged migraine visual aura without headache, whose long-lasting episodes of visual aura were successfully controlled by oral sumatriptan, is reported. Effectiveness of sumatriptan was unequivocal, since, after taking sumatriptan, duration of aura would drop from 1.5 h to approximately 20 min. This case suggests that sumatriptan may cross the blood-brain barrier and block spreading depression. 相似文献