全文获取类型
收费全文 | 1108篇 |
免费 | 74篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 21篇 |
妇产科学 | 6篇 |
基础医学 | 120篇 |
口腔科学 | 4篇 |
临床医学 | 145篇 |
内科学 | 391篇 |
皮肤病学 | 7篇 |
神经病学 | 150篇 |
特种医学 | 45篇 |
外科学 | 100篇 |
综合类 | 9篇 |
预防医学 | 105篇 |
眼科学 | 1篇 |
药学 | 42篇 |
肿瘤学 | 32篇 |
出版年
2024年 | 2篇 |
2023年 | 10篇 |
2022年 | 9篇 |
2021年 | 33篇 |
2020年 | 25篇 |
2019年 | 30篇 |
2018年 | 35篇 |
2017年 | 22篇 |
2016年 | 22篇 |
2015年 | 25篇 |
2014年 | 40篇 |
2013年 | 44篇 |
2012年 | 82篇 |
2011年 | 81篇 |
2010年 | 37篇 |
2009年 | 34篇 |
2008年 | 75篇 |
2007年 | 72篇 |
2006年 | 57篇 |
2005年 | 52篇 |
2004年 | 40篇 |
2003年 | 30篇 |
2002年 | 37篇 |
2001年 | 33篇 |
2000年 | 23篇 |
1999年 | 39篇 |
1998年 | 5篇 |
1997年 | 7篇 |
1996年 | 16篇 |
1995年 | 5篇 |
1994年 | 13篇 |
1993年 | 6篇 |
1992年 | 22篇 |
1991年 | 16篇 |
1990年 | 16篇 |
1989年 | 14篇 |
1988年 | 15篇 |
1987年 | 10篇 |
1986年 | 8篇 |
1985年 | 11篇 |
1984年 | 11篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1979年 | 2篇 |
1975年 | 2篇 |
1974年 | 2篇 |
1973年 | 2篇 |
1971年 | 1篇 |
1970年 | 2篇 |
1969年 | 1篇 |
排序方式: 共有1187条查询结果,搜索用时 15 毫秒
101.
Judith L. Thijs Ian Strickland Carla A.F.M. Bruijnzeel-Koomen Stefan Nierkens Barbara Giovannone Edward F. Knol Eszter Csomor Bret R. Sellman Tomas Mustelin Matthew A. Sleeman Marjolein S. de Bruin-Weller Athula Herath Julia Drylewicz Richard D. May DirkJan Hijnen 《The Journal of allergy and clinical immunology》2018,141(4):1523-1526
102.
H. J. Schim van der Loeff R. J. M. Strack van Schijndel L. G. Thijs 《Intensive care medicine》1988,15(1):58-59
A 29-year-old woman suffered a cardiac arrest, due to profound hyperkalaemia, caused by the use of a potassium-containing salt substitute. She was resuscitated, but post-hypoxic brain damage occurred. Some of the sparse literature is reviewed. 相似文献
103.
Plasma lipid peroxides and antioxidants in human septic shock 总被引:3,自引:0,他引:3
A. C. Ogilvie M.D. A. B. J. Groeneveld J. P. Straub L. G. Thijs 《Intensive care medicine》1991,17(1):40-44
In order to assess if an oxidant/antioxidant imaalance is involved in human septic shock and its outcome, we measured plasma levels of the lipid peroxides malondialdehyde—as thiobarbituric acid reactive substance—conjugated dienes and fluorescent products, together with the antioxidants alpha-tocopherol, glutathione peroxidase activity and selenium in 12 patients with septic shock and compared them with values of normal controls. At first measurements, malondialdehyde (median 3.9 mol/l; range 2–38.8) and fluorescent products (median 21.2%; range 9.4–134) were elevated (p<0.05), alpha-tocopherol (median 15 mol/l; range 7–25) and selenium (median 0.76 g/ml; range 0.49–1.09) were depressed (p<0.05). Conjugated dienes and glutathione peroxidase activity were in the normal range. In non-survivors (n=5) initial levels of malondialdehyde and fluorescent products (median 11 versus 3.1 mol/l; 74 versus 135 respectively) were higher than in survivors (p<0.05) and initial selenium levels were lower (median 0.58 versus 0.92 g/l;p<0.05). These results are consistent with the concept that an oxidant/antioxidant imbalance—as indicated by elevated plasma lipid peroxides and depressed antioxidants—is involved in human septic shock and a fatal outcome. 相似文献
104.
105.
106.
107.
The effect of mild endotoxemia during low arginine plasma levels on organ blood flow in rats 总被引:3,自引:0,他引:3
Prins HA Houdijk AP Wiezer MJ Teerlink T van Lambalgen AA Thijs LG van Leeuwen PA 《Critical care medicine》2000,28(6):1991-1997
OBJECTIVE: Arginine is the sole precursor in the generation of the vasodilating agent nitric oxide. Arginine plasma levels are low in situations associated with endotoxemia such as major trauma, sepsis, and experimental obstructive jaundice. The aim of the study was to evaluate hemodynamics at low arginine plasma levels during a low-grade endotoxemia. DESIGN: Randomized, placebo-controlled animal laboratory investigation. SUBJECTS: Male Wistar rats (n = 29), anesthetized. INTERVENTIONS: Rats were randomly assigned to receive (at t = 0 mins) an intravenous infusion of 1.5 mL of 0.9% NaCl (SAL, n = 12) or 1.5 mL of an arginase (3200 IU) solution (ASE, n = 17) over a 20-min period. After the SAL or ASE infusion, rats were randomly assigned to receive an intravenous endotoxin (lipopolysaccharide [LPS], 150 microg/kg in 1.0 mL of 0.9% NaCl; ASE/LPS, n = 10 and SAL/LPS, n = 6) challenge or a control infusion (1.0 mL of 0.9% NaCl; ASE/SAL, n = 7 and SAL/SAL, n = 6) at t = 30 mins. MEASUREMENTS AND MAIN RESULTS: Organ blood flow was measured at t = 270 mins, using radiolabeled microspheres. At this time point, arginine plasma levels were lower in the ASE-treated rats (ASE/SAL vs. SAL/SAL and ASE/LPS vs. SAL/LPS, both p < .005, respectively). Cardiac output, mean arterial pressure, and therefore total peripheral resistance were similar for all groups. In the LPS-treated animals (SAL/LPS and ASE/LPS), cardiac output was maintained by a higher heart rate compensating the lower stroke volume. Organ blood flow to the small intestine and splanchnic blood flow was lower in the ASE/LPS-treated rats (both p < .05 when compared with other groups). Total liver blood flow was similar for all groups; the lower splanchnic blood flow was compensated for by a higher hepatic arterial blood flow. CONCLUSION: The present study shows that low arginine plasma levels do not influence organ blood flow, whereas, during a low-grade endotoxemia, low arginine plasma levels result in reduced blood flow to the small intestine. 相似文献
108.
109.
Arginase release from red blood cells: possible link in transfusion induced immune suppression? 总被引:6,自引:0,他引:6
Prins HA Houdijk AP Nijveldt RJ Teerlink T Huygens P Thijs LG van Leeuwen PA 《Shock (Augusta, Ga.)》2001,16(2):113-115
Arginine stimulates lymphocyte function and is degraded by arginase, an enzyme that is abundantly present in red blood cells. Arginase impairs lymphocyte function and responses in vitro. Leakage of arginase from stored red blood cells may be involved in the lymphocyte dysfunction associated in allogenic blood transfusion. In the present study, arginase activity was determined in bags of red cells stored for transfusion. Buffy coat depleted red blood cells were obtained routinely from four healthy donors and stored in bags for a maximum period of five weeks at 4 degrees C. The bags were sampled for determination of arginase, lactate dehydrogenase, and potassium. In addition, a random sample of 36 bags of red blood cells about to be transfused to patients were studied. Levels of arginase, lactate dehydrogenase, and potassium showed a time dependent increase in the bags of the four donors. This time dependent increase in arginase activity could be confirmed in the additional bags sampled (P < 0.0001, r = 0.78). The results for the first time show that arginase is released from red blood cells during storage for transfusion. Arginase infusion may play an important role in the immune suppression observed after blood transfusion. 相似文献
110.
A A van Lambalgen A A van Kraats G C van den Bos H V Stel J Straub A J Donker L G Thijs 《Circulatory shock》1991,35(3):164-173
Renal failure often complicates endotoxin shock. This might be due to renal hypoperfusion, but endotoxemia could also have additional effects. We studied in anesthetized rats renal plasma flow (RPF), glomerular filtration rate (GFR), and metabolism (ATP, CrP = creatine phosphate, energy charge = [ATP + 0.5 ADP]/[ATP + ADP + AMP], lactate, glucose) during endotoxin shock (Escherichia coli endotoxin, 10 mg/kg for 60 min; n = 10) and "balloon shock" (balloon inflated in vena cava below renal vein to cause comparable decreases in cardiac output and RPF as in endotoxin-treated rats; n = 10). A third group of rats served as controls (n = 10). At t = 0 infusion of endotoxin was started. At t = 90 min, when cardiac output was low and serum lactate was high (indicating shock), GFR and RPF were obtained from plasma disappearance rates (from t = 90 to t = 135 min) of 125I-thalamate and 131I-hippurate, respectively. Experiments ended at t = 135 min. In both shock groups RPF decreased (by ca. - 75% compared with control rats), but filtration fraction only increased (by 72%) in the "balloon shock" rats. In renal biopsies lactate concentration increased more (by 407 vs. 167%) and ATP decreased more (by -63 vs. - 35%) during endotoxin shock than during "balloon shock"; the endotoxin-treated rats also showed a significant decrease in CrP (by - 58%), energy charge (by - 31%), and glucose concentration (by - 34%), and an increase in the number of leukocytes in the glomeruli (by 730%). Renal function and metabolism thus was more affected in this hypodynamic form of endotoxin shock than in "balloon shock." This may be caused by the effects of endotoxin on sticking of leukocytes and renal metabolism. 相似文献