全文获取类型
收费全文 | 949篇 |
免费 | 55篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 27篇 |
儿科学 | 14篇 |
妇产科学 | 8篇 |
基础医学 | 126篇 |
口腔科学 | 155篇 |
临床医学 | 76篇 |
内科学 | 177篇 |
皮肤病学 | 36篇 |
神经病学 | 85篇 |
特种医学 | 29篇 |
外科学 | 78篇 |
综合类 | 6篇 |
预防医学 | 103篇 |
眼科学 | 10篇 |
药学 | 54篇 |
中国医学 | 6篇 |
肿瘤学 | 20篇 |
出版年
2023年 | 11篇 |
2022年 | 21篇 |
2021年 | 65篇 |
2020年 | 41篇 |
2019年 | 43篇 |
2018年 | 54篇 |
2017年 | 34篇 |
2016年 | 42篇 |
2015年 | 38篇 |
2014年 | 66篇 |
2013年 | 63篇 |
2012年 | 91篇 |
2011年 | 106篇 |
2010年 | 50篇 |
2009年 | 24篇 |
2008年 | 64篇 |
2007年 | 44篇 |
2006年 | 23篇 |
2005年 | 30篇 |
2004年 | 15篇 |
2003年 | 19篇 |
2002年 | 20篇 |
2001年 | 2篇 |
1999年 | 2篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1995年 | 3篇 |
1994年 | 4篇 |
1993年 | 3篇 |
1992年 | 1篇 |
1990年 | 1篇 |
1989年 | 2篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1982年 | 1篇 |
1980年 | 3篇 |
1978年 | 1篇 |
1977年 | 2篇 |
1973年 | 1篇 |
1947年 | 1篇 |
1942年 | 1篇 |
1938年 | 2篇 |
1937年 | 1篇 |
1936年 | 2篇 |
1935年 | 1篇 |
1930年 | 3篇 |
1928年 | 1篇 |
1922年 | 1篇 |
排序方式: 共有1010条查询结果,搜索用时 46 毫秒
21.
22.
Rare genomic rearrangement in a boy with Williams–Beuren syndrome associated to XYY syndrome and intriguing behavior
下载免费PDF全文
![点击此处可从《American journal of medical genetics. Part A》网站下载免费的PDF全文](/ch/ext_images/free.gif)
23.
24.
Alexandre Kanashiro Thais Oliveira de Lucena Leoncio Ayda Henriques Schneider Hélio Rocha Alves Gabriel Shimizu Bassi Sabrina Graziani Veloso Dutra Fernando de Queiróz Cunha Luis Ulloa David do Carmo Malvar 《Pharmacological reports : PR》2019,71(6):1095-1103
BackgroundThe regulation of the immune system by the sympathetic nervous system is allowing the design of novel treatments for inflammatory disorders such as arthritis. In this study, we have analyzed the effects of α- and β-adrenoceptor agonists injected subcutaneously, intrathecally, or intra-articularly in zymosan-induced arthritis.MethodsMurine arthritis was induced by intra-articular (knee joint) injection of zymosan. α1 (phenylephrine), α2 (clonidine), β1 (dobutamine), or β2 (salbutamol)-adrenoceptor agonists were injected subcutaneously (sc), intrathecally (it), or intra-articularly (ia) to activate peripheral, spinal, or intra-articular adrenoceptors and to study their effects on articular edema formation and neutrophil migration into the synovial cavity.ResultsTreatments with phenylephrine did not affect the edema formation, but it increased neutrophil migration when injected subcutaneously (155.3%) or intra-articularly (187.7%). Treatments with clonidine inhibited neutrophil migration (59.9% sc, 68.7% it, 42.8% ia) regardless of the route of administration, but it inhibited edema formation only when injected intrathecally (66.7%) or intra-articularly (36%) but not subcutaneously. Treatments with dobutamine inhibited both edema (42.0% sc, 69.5% it, 61.6% ia) and neutrophil migration (28.4% sc, 70.3% it, 82.4% ia) in a concentration dependent manner. Likewise, all the treatments with salbutamol also inhibited edema formation (89.9% sc, 62.4% it, 69.8% ia) and neutrophil migration (76.6% sc, 39.1% it, 71.7% ia).ConclusionWhereas the β-adrenoceptor agonists induced anti-inflammatory effects regardless of their route of administration, α1- and α2-adrenoceptor agonists induced either pro- and anti-inflammatory effects, respectively. 相似文献
25.
Hammes TO Pedroso GL Hartmann CR Escobar TD Fracasso LB da Rosa DP Marroni NP Porawski M da Silveira TR 《Digestive diseases and sciences》2012,57(3):675-682
Background
Nonalcoholic fatty liver disease is one of the most prevalent forms of chronic liver disease in the Western world. Taurine is a conditionally essential amino acid in humans that may be a promising therapy for treating this disease. 相似文献26.
Freitas JA das Neves LT de Almeida AL Garib DG Trindade-Suedam IK Yaedú RY Lauris Rde C Soares S Oliveira TM Pinto JH 《Journal of applied oral science : revista FOB》2012,20(1):9-15
Cleft lip and palate is the most common among craniofacial malformations and causes several esthetic and functional implications that require rehabilitation. This paper aims to generally describe the several aspects related to this complex pathology and the treatment protocol used by the Hospital for Rehabilitation of Craniofacial Anomalies, University of S?o Paulo (HRAC-USP) along 40 years of experience in the treatment of individuals with cleft lip and palate. 相似文献
27.
Teresa Cristina Barros Schütz Thays Crosara Abrah?o Cunha Thais Moura-Guimaraes Gabriela Pontes Luz Carolina Ackel-D'Elia Eduardo da Silva Alves Gilberto Pantiga Junior Marco Tulio de Mello Sergio Tufik Lia Bittencourt 《Clinics (S?o Paulo, Brazil)》2013,68(8):1168-1174
OBJECTIVE:
There are several treatments for obstructive sleep apnea syndrome, such as weight loss, use of an oral appliance and continuous positive airway pressure, that can be used to reduce the signs and symptoms of obstructive sleep apnea syndrome. Few studies have evaluated the effectiveness of a physical training program compared with other treatments. The aim of this study was to assess the effects of physical exercise on subjective and objective sleep parameters, quality of life and mood in obstructive sleep apnea patients and to compare these effects with the effects of continuous positive airway pressure and oral appliance treatments.METHODS:
Male patients with moderate to severe obstructive sleep apnea and body mass indices less than 30 kg/m2 were randomly assigned to three groups: continuous positive airway pressure (n = 9), oral appliance (n = 9) and physical exercise (n = 7). Polysomnographic recordings, blood samples and daytime sleepiness measurements were obtained prior to and after two months of physical exercise or treatment with continuous positive airway pressure or an oral appliance. Clinicaltrials.gov: NCT01289392RESULTS:
After treatment with continuous positive airway pressure or an oral appliance, the patients presented with a significant reduction in the apnea-hypopnea index. We did not observe changes in the sleep parameters studied in the physical exercise group. However, this group presented reductions in the following parameters: T leukocytes, very-low-density lipoprotein and triglycerides. Two months of exercise training also had a positive impact on subjective daytime sleepiness.CONCLUSIONS:
Our results suggest that isolated physical exercise training was able to modify only subjective daytime sleepiness and some blood measures. Continuous positive airway pressure and oral appliances modified the apnea-hypopnea index. 相似文献28.
29.
The pediatric origin of osteoporosis has led many investigators to focus on determining factors that influence bone gain during growth and methods for optimizing this gain. Bone responds to bone loading activities by increasing mass or size. Overall, pediatric studies have found a positive effect of bone loading on bone size and accrual, but the types of loads necessary for a bone response have only recently been investigated in human studies. Findings indicate that responses vary by sex, maturational status, and are site-specific. Estrogen status, body composition, and nutritional status also may influence the bone response to loading. Despite the complex interrelationships among these various factors, it is prudent to conclude that increased physical activity throughout life is likely to optimize bone health. 相似文献
30.
Thais Aglaet Matos MIRANDA Sandra Kiss MOURA Vitor Hugo de Oliveira AMORIM Raquel Sano Suga TERADA Renata Corrêa PASCOTTO 《Journal of applied oral science : revista FOB》2013,21(6):567-574