The acute toxicity of butylated hydroxytoluene and its metabolites in mice

The acute toxicity of butylated hydroxytoluene (BHT) and four of its metabolites, 2,6-di-tert-butyl-4-hydroperoxy-4-methyl-2,5-cyclohexadien- 1-one(BHT-OOH), 2,6-di-tert-butyl-4-hydroxy-4-methyl-2,5-cyclohexadien- 1-one(BHT-OH), 2,6-di-tert-butyl-p-benzoquinone (DBQ), and 2,6-di-tert- butyl-4-[(methylthio)methyl] phenol (BHT-SCH₃) was studied in young male mice following intraperitoneal administration. The i.p. LD₅₀ values of BHT, BHT-OOH, BHT-OH, DBQ, and BHT-SCH₃ were 3550,190, above 1600, 2270, and 1840 $\text{mg}\text{kg}$, respectively. These results suggest that BHT-OOH probably is the most toxic metabolite of BHT.     

Absent skeletal uptake of <Superscript>99m</Superscript>Tc-hydroxymethylene diphosphonate in the presence of AL-type amyloidosis associated with multiple myeloma

A 66-year-old woman with congestive heart failure suspected to have multiple myeloma underwent bone scintigraphy. The bone scintigraphy using technetium-99m hydroxymethylene-diphosphonate showed the following interesting findings: absent skeletal uptake; increased gastrointestinal, myocardial, and soft tissue uptake; migration of radionuclide to bilateral pleural effusions. Histopathological examination revealed that the patient suffered from AL-type amyloidosis associated with multiple myeloma. Extraosseous uptake is often observed on bone scintigraphy in amyloidosis patients, but in many cases skeletal uptake is preserved. The simultaneous presentation of these findings is rare.