全文获取类型
收费全文 | 2570篇 |
免费 | 164篇 |
国内免费 | 25篇 |
专业分类
耳鼻咽喉 | 44篇 |
儿科学 | 34篇 |
妇产科学 | 11篇 |
基础医学 | 291篇 |
口腔科学 | 46篇 |
临床医学 | 203篇 |
内科学 | 817篇 |
皮肤病学 | 75篇 |
神经病学 | 239篇 |
特种医学 | 76篇 |
外科学 | 473篇 |
综合类 | 8篇 |
预防医学 | 73篇 |
眼科学 | 42篇 |
药学 | 170篇 |
中国医学 | 5篇 |
肿瘤学 | 152篇 |
出版年
2024年 | 2篇 |
2023年 | 18篇 |
2022年 | 59篇 |
2021年 | 89篇 |
2020年 | 54篇 |
2019年 | 95篇 |
2018年 | 85篇 |
2017年 | 64篇 |
2016年 | 78篇 |
2015年 | 68篇 |
2014年 | 106篇 |
2013年 | 144篇 |
2012年 | 199篇 |
2011年 | 219篇 |
2010年 | 115篇 |
2009年 | 84篇 |
2008年 | 161篇 |
2007年 | 166篇 |
2006年 | 151篇 |
2005年 | 146篇 |
2004年 | 158篇 |
2003年 | 147篇 |
2002年 | 129篇 |
2001年 | 29篇 |
2000年 | 28篇 |
1999年 | 27篇 |
1998年 | 20篇 |
1997年 | 20篇 |
1996年 | 6篇 |
1995年 | 6篇 |
1994年 | 7篇 |
1993年 | 4篇 |
1992年 | 9篇 |
1991年 | 4篇 |
1990年 | 6篇 |
1989年 | 6篇 |
1988年 | 5篇 |
1987年 | 4篇 |
1986年 | 4篇 |
1985年 | 3篇 |
1984年 | 2篇 |
1981年 | 3篇 |
1980年 | 4篇 |
1979年 | 2篇 |
1975年 | 6篇 |
1974年 | 3篇 |
1973年 | 4篇 |
1972年 | 4篇 |
1969年 | 3篇 |
1968年 | 1篇 |
排序方式: 共有2759条查询结果,搜索用时 15 毫秒
61.
Satoshi Kanai Taku Miyashita Tatsumi Tada 《International Journal on Interactive Design and Manufacturing》2007,1(3):175-179
This paper proposes a high-level architecture-based multi-disciplinary distributed simulation environment for designing mechatronic
systems. In the system, commercial off-the-shelf simulators can communicate each other via real-time-infrastructure to realize
software-in-the-loop simulation. Moreover, hardware prototypes can also participate in a part of the distributed simulation
environment which enable us hardware-in-the-loop simulation. Effectiveness was verified by applying the environment to mechatronic
system design of an automotive power-window and an omni-directional electric wheel chair. 相似文献
62.
63.
Carlos Collet Yosuke Miyazaki Nicola Ryan Taku Asano Erhan Tenekecioglu Jeroen Sonck Daniele Andreini Manel Sabate Salvatore Brugaletta Rodney H. Stables Antonio Bartorelli Robbert J. de Winter Yuki Katagiri Ply Chichareon Giovanni Luigi De Maria Pannipa Suwannasom Rafael Cavalcante Hans Jonker Patrick W. Serruys 《Journal of the American College of Cardiology》2018,71(24):2756-2769
Background
The functional SYNTAX score (FSS) has been shown to improve the discrimination for major adverse cardiac events compared with the anatomic SYNTAX score (SS) while reducing interobserver variability. However, evidence supporting the noninvasive FSS in patients with multivessel coronary artery disease (CAD) is scarce.Objectives
The purpose of this study was to assess the feasibility of and validate the noninvasive FSS derived from coronary computed tomography angiography (CTA) with fractional flow reserve (FFRCT) in patients with 3-vessel CAD.Methods
The CTA-SS was calculated in patients with 3-vessel CAD included in the SYNTAX II (SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery II) study. The noninvasive FSS was determined by including only ischemia-producing lesions (FFRCT ≤0.80). SS derived from different imaging modalities were compared using the Bland-Altman and Passing-Bablok method, and the agreement on the SS tertiles was investigated with Cohen’s Kappa. The risk reclassification was compared between the noninvasive and invasive physiological assessment, and the diagnostic accuracy of FFRCT was assessed by the area under the receiver-operating characteristic curve using instantaneous wave-free ratio as a reference.Results
The CTA-SS was feasible in 86% of patients (66 of 77), whereas the noninvasive FSS was feasible in 80% (53 of 66). The anatomic SS was overestimated by CTA compared with conventional angiography (27.6 ± 6.4 vs. 25.3 ± 6.9; p < 0.0001) whereas the calculation of the FSS yielded similar results between the noninvasive and invasive imaging modalities (21.6 ± 7.8 vs. 21.2 ± 8.8; p = 0.589). The noninvasive FSS reclassified 30% of patients from the high- and intermediate-SS tertiles to the low-risk tertile, whereas invasive FSS reclassified 23% of patients from the high- and intermediate-SS tertiles to the low-risk tertile. The agreement on the classic SS tertiles based on Kappa statistics was slight for the anatomic SS (Kappa = 0.19) and fair for the FSS (Kappa = 0.32). The diagnostic accuracy of FFRCT to detect functional significant stenosis based on an instantaneous wave-free ratio ≤0.89 revealed an area under the receiver-operating characteristics curve of 0.85 (95% CI: 0.79 to 0.90) with a sensitivity of 95% (95% CI: 89% to 98%), specificity of 61% (95% CI: 48% to 73%), positive predictive value of 81% (95% CI: 76% to 86%), and negative predictive value of 87% (95% CI: 74% to 94%).Conclusions
Calculation of the noninvasive FSS is feasible and yielded similar results to those obtained with invasive pressure-wire assessment. The agreement on the SYNTAX score tertile classification improved with the inclusion of the functional component from slight to fair agreement. FFRCT has good accuracy in detecting functionally significant lesions in patients with 3-vessel CAD. (A Trial to Evaluate a New Strategy in the Functional Assessment of 3-Vessel Disease Using SYNTAX II Score in Patients Treated With PCI; NCT02015832) 相似文献64.
65.
Clinical significance of bile reflux into the pancreatic duct without pancreaticobiliary maljunction assessed by intraoperative cholangiography
下载免费PDF全文
![点击此处可从《Asian journal of endoscopic surgery》网站下载免费的PDF全文](/ch/ext_images/free.gif)
66.
67.
Taku Oishi Mikiya Fujieda Taisuke Shiraishi Miki Ono Kazuo Inoue Akiyoshi Takahashi Hideo Ogura Hiroshi Wakiguchi 《Circulation journal》2008,72(5):850-852
Tumor necrosis factor-alpha (TNF-alpha) is considered to be 1 of the factors that induce vasculitis, including coronary artery aneurysm (CA), in Kawasaki disease (KD), because the blood concentration of TNF-alpha is higher in patients with CA compared with those without. Therefore, an anti-TNF-alphaagent (infliximab) was administered to a 1-month-old girl with refractory KD complicated by CA and subsequently, the CA improved and KD was controlled without complications 20 months after the onset. 相似文献
68.
Kazuhiro OSANAI Chiharu TSUCHIHARA Rieko HATTA Taku OIKAWA Katsuma TSUCHIHARA Masaharu IGUCHI Toshimitsu SEKI Masakatsu TAKAHASHI Jyongsu HUANG Hirohisa TOGA 《Respirology (Carlton, Vic.)》2006,11(S1):S70-S73
Abstract: Pulmonary surfactant (PS) is a mixture of several lipids (mainly phosphatidylcholine; PC) and four apoproteins (A, B, C and D). The classical hypothesis of PS transport suggests that PS is synthesized in the endoplasmic reticulum and transported to the lamellar body (LB) via the Golgi apparatus. However, recent studies have raised questions regarding this single route. This study examined, independently, the intracellular trafficking route of three different components of PS, that is, PC, SP-A and SP-B. Alveolar type II cells were isolated from Sprague–Dawley rats or Japanese white rabbits. The cells were cultured with either [3 H]choline or [35 S]methionine/cysteine with or without brefeldin A, which disassembles the Golgi apparatus. LB was purified from disintegrated cells with sucrose density gradient centrifugation. [3 H]PC was extracted from radiolabeled media, cells, and the LB fraction with Bligh–Dyer's method. [35 S]SP-A or [35 S]SP-B was immunoprecipitated from each sample with a specific antibody. [3 H]PC was transported and stored to the LB via a Golgi-independent pathway. [35 S]SP-A was transported to the Golgi apparatus, underwent glycosylation, and was then constitutively secreted. The secreted [35 S]SP-A was re-uptaken into the LB. [35 S]SP-B was transported and stored to the LB via the Golgi-dependent pathway. These results indicate that, rather than a single route, surfactant components take different pathways to reside in the LB. These different pathways may reflect the different nature and role of each surfactant component such as surface tension-lowering activity and innate host defense. 相似文献
69.
70.
The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia 总被引:6,自引:0,他引:6
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Junge CE Sugawara T Mannaioni G Alagarsamy S Conn PJ Brat DJ Chan PH Traynelis SF 《Proceedings of the National Academy of Sciences of the United States of America》2003,100(22):13019-13024
The serine proteases tissue plasminogen activator, plasmin, and thrombin and their receptors have previously been suggested to contribute to neuronal damage in certain pathological situations. Here we demonstrate that mice lacking protease-activated receptor 1 (PAR1) have a 3.1-fold reduction in infarct volume after transient focal cerebral ischemia. Intracerebroventricular injection of PAR1 antagonist BMS-200261 reduced infarct volume 2.7-fold. There are no detectable differences between PAR1-/- and WT mice in cerebrovascular anatomy, capillary density, or capillary diameter, demonstrating that the neuroprotective phenotype is not likely related to congenital abnormalities in vascular development. We also show that the exogenously applied serine proteases thrombin, plasmin, and tissue plasminogen activator can activate PAR1 signaling in brain tissue. These data together suggest that if blood-derived serine proteases that enter brain tissue in ischemic situations can activate PAR1, this sequence of events may contribute to the harmful effects observed. Furthermore, PAR1 immunoreactivity is present in human brain, suggesting that inhibition of PAR1 may provide a novel potential therapeutic strategy for decreasing neuronal damage associated with ischemia and blood-brain barrier breakdown. 相似文献