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Yuko Shima Koichi Nakanishi Taketsugu Hama Hironobu Mukaiyama Hiroko Togawa Mayumi Sako Hiroshi Kaito Kandai Nozu Ryojiro Tanaka Kazumoto Iijima Norishige Yoshikawa 《Pediatric nephrology (Berlin, Germany)》2013,28(1):71-76
Background
Some patients with IgA nephropathy (IgAN) achieve spontaneous remission even when not receiving medication. However, details on such remissions remain unknown. The aim of our study was to clarify this information in the clinical setting of childhood IgAN with minor glomerular abnormalities or focal mesangial proliferation (MGA/FMP).Methods
This study was a retrospective analysis of 96 children with MGA/FMP who did not receive medication from among the 555 patients with newly diagnosed childhood IgAN treated between January 1972 and December 2000. The Kaplan?CMeier method and Cox proportional hazard model were used for the analysis.Results
Of the 96 pediatric patients who did not receive medication, 57 (59.4?%) achieved spontaneous remission. The cumulative spontaneous remission rates among these patients were 57.5? and 77.4 % at 5?and 10 years, respectively, from onset. The mean time from onset to remission was 5.9?±?0.4?years. Clinical and histological findings were similar between the remission and non-remission groups. Of the 57 patients with spontaneous remissions, ten (17.5?%) also developed a recurrence of urinary abnormalities. The cumulative recurrence-free rates were 79.9?and 67.9 % at 5 and 10?years, respectively, after remission.Conclusions
The spontaneous remission rate in childhood IgAN with MGA/FMP was higher than expected. Our results suggest that physicians should consider the potential for spontaneous remission and refrain from very aggressive treatment in IgAN patients with MGA/FMP. 相似文献104.
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Horinouchi Tomoko Maeyama Kaori Nagai Masashi Mizobuchi Masami Takagi Yasuko Okada Yuka Kato Takeshi Nishimura Mio Kawasaki Yoko Yoshioka Mieko Takada Satoshi Matsumoto Hisayuki Nakamachi Yuji Saegusa Jun Fukushima Sachiyo Fujioka Kazumichi Tomioka Kazumi Nagase Hiroaki Nozu Kandai Iijima Kazumoto Nishimura Noriyuki 《Journal of autism and developmental disorders》2022,52(2):483-489
Journal of Autism and Developmental Disorders - Neonatal jaundice has been suggested as a perinatal risk factor for autism spectrum disorder (ASD). We examined UGT1A1 polymorphisms to assess the... 相似文献
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Murakoshi Miki Kamei Koichi Ogura Masao Sato Mai Nada Taishi Suzuki Ryutaro Kamae Chikako Nishi Kentaro Kanamori Toru Nagano China Nozu Kandai Nakanishi Koichi Iijima Kazumoto 《Clinical and experimental nephrology》2022,26(2):162-169
Clinical and Experimental Nephrology - The management of congenital nephrotic syndrome of the Finnish type (CNF) is challenging. It is difficult to withdraw intravenous albumin infusions, resulting... 相似文献
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