全文获取类型
| 收费全文 | 3692110篇 |
| 免费 | 261641篇 |
| 国内免费 | 9607篇 |
专业分类
| 耳鼻咽喉 | 52267篇 |
| 儿科学 | 118903篇 |
| 妇产科学 | 102218篇 |
| 基础医学 | 520045篇 |
| 口腔科学 | 105555篇 |
| 临床医学 | 332524篇 |
| 内科学 | 717126篇 |
| 皮肤病学 | 85843篇 |
| 神经病学 | 300828篇 |
| 特种医学 | 144144篇 |
| 外国民族医学 | 1093篇 |
| 外科学 | 562677篇 |
| 综合类 | 75772篇 |
| 现状与发展 | 5篇 |
| 一般理论 | 1357篇 |
| 预防医学 | 277800篇 |
| 眼科学 | 86153篇 |
| 药学 | 272145篇 |
| 10篇 | |
| 中国医学 | 7680篇 |
| 肿瘤学 | 199213篇 |
出版年
| 2018年 | 40083篇 |
| 2017年 | 30997篇 |
| 2016年 | 35760篇 |
| 2015年 | 40230篇 |
| 2014年 | 55219篇 |
| 2013年 | 83120篇 |
| 2012年 | 111096篇 |
| 2011年 | 117493篇 |
| 2010年 | 70783篇 |
| 2009年 | 67289篇 |
| 2008年 | 110908篇 |
| 2007年 | 117776篇 |
| 2006年 | 119748篇 |
| 2005年 | 115962篇 |
| 2004年 | 111346篇 |
| 2003年 | 107646篇 |
| 2002年 | 104504篇 |
| 2001年 | 173986篇 |
| 2000年 | 178555篇 |
| 1999年 | 151454篇 |
| 1998年 | 43122篇 |
| 1997年 | 38111篇 |
| 1996年 | 38043篇 |
| 1995年 | 36428篇 |
| 1994年 | 33614篇 |
| 1993年 | 31691篇 |
| 1992年 | 117940篇 |
| 1991年 | 113624篇 |
| 1990年 | 110595篇 |
| 1989年 | 107091篇 |
| 1988年 | 98317篇 |
| 1987年 | 96576篇 |
| 1986年 | 91017篇 |
| 1985年 | 86969篇 |
| 1984年 | 64759篇 |
| 1983年 | 55082篇 |
| 1982年 | 32310篇 |
| 1981年 | 28709篇 |
| 1979年 | 58634篇 |
| 1978年 | 41092篇 |
| 1977年 | 35029篇 |
| 1976年 | 32420篇 |
| 1975年 | 35001篇 |
| 1974年 | 41746篇 |
| 1973年 | 39828篇 |
| 1972年 | 37509篇 |
| 1971年 | 34861篇 |
| 1970年 | 32841篇 |
| 1969年 | 31334篇 |
| 1968年 | 28921篇 |
排序方式： 共有10000条查询结果，搜索用时 515 毫秒
81.
Thomas Ruffing Tilmann Rückauer Frederic Bludau Alexander Hofmann Markus Muhm Arnold J Suda 《Injury》2019,50(2):607-612
Introduction
Compression fractures of the cuboid bone in children and adolescents are rare. Fracture morphology, associated lesions, treatment options and long-term outcomes of this very rare injury are published in a few case reports. This study with review of the literature aims to support the understanding of fracture pattern and optimize pathways of decision making.Material and Methods
A retrospective two-center study was performed in a patient cohort treated between 2001 and 2016. All patients aged less than 18 years who sustained a cuboid fracture were included. Age, gender, mechanism of injury, fracture morphology, amount of displacement, associated injuries, and therapy were analyzed. In the follow-up (FU), the AOFAS Midfoot Scale was investigated.Results
Fractures of the cuboid bone were diagnosed in 7 boys and 9 girls. The mean age of the patients was 10 years (range: 2.2–16.1 years). According to the classification of Fenton we detected 11 (69%) type 2, 2 (12%) type 3 and 3 (19%) type 5b fractures. Other fracture types according to Fenton were not observed. All children under 10 years sustained a type 2 fracture. Open reduction and internal fixation was performed in 5 (31%) patients. Bone grafting was not necessary. FU was performed in 14/16 patients on average after 9 years (mean; range: 1.4–16.2 years). The mean AOFAS Midfoot Scale at FU for extra-articular type 2 fractures was 100 points, whereas in intra-articular fractures (Type 3) and fractures associated with mid-tarsal disruption (type 5b) worse results were found (95 and 66 points, accordingly).Conclusion
This rare injury shows inhomogenous morphologies and offers different treatment approaches. Extra-articular Fenton type 2 lesions are the most common type of cuboid fracture in children (69%). A potential loss of length of the lateral column must be considered. In contrast to adults, type 1, 4, and 5a fractures were not found in our cohort of children and adolescents. Lower scores of the AOFAS Midfoot Scale were found with either intra-articular involvement or associated midfoot lesions. 相似文献82.
Elizabeth D. Krebs Robert B. Hawkins J. Hunter Mehaffey Clifford E. Fonner Alan M. Speir Mohammed A. Quader Jeffrey B. Rich Leora T. Yarboro Nicholas R. Teman Gorav Ailawadi 《The Journal of thoracic and cardiovascular surgery》2019,157(4):1533-1542.e2
Objectives
Expedient extubation after cardiac surgery has been associated with improved outcomes, leading to postoperative extubation frequently during overnight hours. However, recent evidence in a mixed medical-surgical intensive care unit population demonstrated worse outcomes with overnight extubation. This study investigated the impact of overnight extubation in a statewide, multicenter Society of Thoracic Surgeons database.Methods
Records from 39,812 patients undergoing coronary artery bypass grafting or valve operations (2008-2016) and extubated within 24 hours were stratified according to extubation time between 06:00 and 18:00 (day) or between 18:00 and 6:00 (overnight). Outcomes including reintubation, mortality, and composite morbidity-mortality were evaluated using hierarchical regression models adjusted for Society of Thoracic Surgeons predictive risk scores. To further analyze extubation during the night, a subanalysis stratified patients into 3 groups: 06:00 to 18:00, 18:00 to 24:00, and 24:00 to 06:00.Results
A total of 20,758 patients were extubated overnight (52.1%) and were slightly older (median age 66 vs 65 years, P < .001) with a longer duration of ventilation (4 vs 7 hours, P < .001). Day and overnight extubation were associated with equivalent operative mortality (1.7% vs 1.7%, P = .880), reintubation (3.7% vs 3.4%, P = .141), and composite morbidity-mortality (8.2% vs 8.0%, P = .314). After risk adjustment, overnight extubation was not associated with any difference in reintubation, mortality, or composite morbidity-mortality. On subanalysis, those extubated between 24:00 and 06:00 exhibited increased composite morbidity-mortality (odds ratio, 1.18; P = .001) but no difference in reintubation or mortality.Conclusions
Extubation overnight was not associated with increased mortality or reintubation. These results suggest that in the appropriate clinical setting, it is safe to routinely extubate cardiac surgery patients overnight. 相似文献83.
Notfall + Rettungsmedizin - 相似文献
84.
85.
86.
Nicholas E. Anton Tomoko Mizota Lava R. Timsina Jake A. Whiteside Erinn M. Myers Dimitrios Stefanidis 《American journal of surgery》2019,217(2):266-271
Introduction
Several studies demonstrated that simulator-acquired skill transfer to the operating room is incomplete. Our objective was to identify trainee characteristics that predict the transfer of simulator-acquired skill to the operating room.Methods
Trainees completed baseline assessments including intracorporeal suturing (IS) performance, attentional selectivity, self-reported use of mental skills, and self-reported prior clinical and simulated laparoscopic experience and confidence. Residents then followed proficiency-based laparoscopic skills training, and their skill transfer was assessed on a live-anesthetized porcine model. Predictive characteristics for transfer test performance were assessed using multiple linear regression.Results
Thirty-eight residents completed the study. Automaticity, attentional selectivity, resident perceived ability with laparoscopy and simulators, and post-training IS performance were predictive of IS performance during the transfer test.Conclusions
Promoting automaticity, self-efficacy, and attention selectivity may help improve the transfer of simulator-acquired skill. Mental skills training and training to automaticity may therefore be valuable interventions to achieve this goal. 相似文献87.
88.
89.
90.
We report a Chinese family with members affected by epidermolytic ichthyosis (EI), caused by KRT gene mutations. The proband was a 14‐year‐old boy who had simultaneous appearance of nephroblastoma and epidermolytic ichthyosis (EI). Both the patient and his mother exhibited the specific clinical and pathological manifestations of EI. We analysed all exons and flanking sequences of the KRT1 and KRT10 genes using PCR, and found that the proband and his mother had a G>C transition at nucleotide position 1432 in exon 7 of KRT1, resulting in an amino acid substitution of glutamate (GAA) to glutamine (CAA) at codon 478 (E478Q). The KRT10 gene had no mutations. 相似文献