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排序方式: 共有6628条查询结果,搜索用时 15 毫秒
101.
Delfine Cheng Sylvie Shen Xin-Ming Chen Carol Pollock Filip Braet 《Pathology, research and practice》2013
Structural alteration to the microanatomical organization of the glomerular filtration barrier results in proteinuria. Conventional transmission electron microscopy is an important diagnostic tool to assess the degree of ultrastructural damage of the corpusclar filtration unit. However, this approach lacks the ability to collect accurate stereological insights in a relative large tissue volume. Transmission electron tomography offers the ability to gather three-dimensional information with relative ease. Therefore, this contribution aims to highlight what electron tomography can bring to the pathologist in this challenging area of diagnostic practice. 相似文献
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Emilie Ronin Charlotte Pouchy Maryam Khosravi Morgane Hilaire Sylvie Grgoire Armanda Casrouge Sahar Kassem David Sleurs Gaëlle H. Martin Nomie Chanson Yannis Lombardi Guilhem Lalle Harald Wajant Cdric Auffray Bruno Lucas Gilles Marodon Yenkel Grinberg-Bleyer Benoît L. Salomon 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(13)
104.
Combining different assays and chemical analysis to characterize the genotoxicity of waters impacted by textile discharges 下载免费PDF全文
Francine I. Vacchi Josiane A. S. Vendemiatti Vanessa Brosselin Bianca Ferreira da Silva Maria Valnice B. Zanoni Michel DeMeo Sylvie Bony Alain Devaux Gisela A. Umbuzeiro 《Environmental and molecular mutagenesis》2016,57(7):559-571
Waters receiving textile discharges can exhibit genotoxic and mutagenic activity, which has been related to the presence of dyes and aromatic amines as synthesis precursors or byproducts. The aim of this study was to identify dyes and aromatic amines in water samples impacted by textile discharges, and to evaluate the genotoxic responses of these samples using the Salmonella/microsome assay in strains TA98 and YG1041, and the Fpg‐modified comet assay in the RTL‐W1 fish cell line. The genotoxicity of river samples downstream of the discharge was greater than the upstream samples in both of the Ames tests. The Fpg‐modified comet assay detected similar levels of DNA damage in the upstream and downstream samples. Mutagenicity was not detected with TA98, except for the Quilombo River samples, but when YG1041 was used as the tester strain mutagenicity was detected for all sites with a very different profile in upstream sites relative to the other sites. The mutagenic response strongly indicated that aromatic amines or dyes were contributing to the mutagenic activity downstream. The impact of textile discharges was also confirmed by chemical analysis, because the highest concentrations of azo dyes and aromatic amines were detected in the river downstream. This study shows the value of combining assays measuring complementary endpoints to better characterize the mutagenicity of environmental samples, with the advantage that this approach provides an indication of what classes of compounds are responsible for the effect. Environ. Mol. Mutagen. 57:559–571, 2016. © 2016 Wiley Periodicals, Inc. 相似文献
105.
Sylvie LECLERCQ 《Industrial health》2014,52(5):393-398
Workplace design and upkeep, or human factors, are frequently advanced for explaining
so-called Occupational Slip, Trip and Fall Accidents (OSTFAs). Despite scientific
progress, these accidents, and more broadly Occupational Accidents with Movement
Disturbance (OAMDs), are also commonly considered to be “simple”. This paper aims to
stimulate changes in such perceptions by focusing on organisational factors that often
combine with other accident factors to cause movement disturbance and injury in work
situations. These factors frequently lead to arbitration between production and safety,
which involves implementation of controls by workers. These controls can lead to greater
worker exposure to OAMD risk. We propose a model that focuses on such controls to account
specifically for the need to confront production and safety logics within a company and to
enhance the potential for appropriate prevention action. These are then integrated into
the set of controls highlighted by work organisation model developed by the NIOSH. 相似文献
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Marie-Christine Saint-Jacques Élisabeth Godbout Sylvie Drapeau Toula Kourgiantakis Claudine Parent 《Child indicators research》2018,11(6):1831-1865
The probability that children whose parents have separated will become members of a stepfamily has increased considerably in the last decades. This situation has encouraged researchers to document the impact of this family transition on children’s adjustment. The present article examines empirical publications on this subject between 2000 and 2015. Screening and eligibility assessment based on inclusion and exclusion criteria yielded a final sample of 130 studies. The theoretical models used by the authors are described and discussed, with particular attention to how theories are relied upon in this field of research. Second, an examination of the methodology applied allowed us to take a critical look at the way children’s outcomes were examined. The studies’ main results were then analyzed so as to draw up a contemporary portrait of how stepfamily children adjust. Finally, an examination of the studies’ limitations and theoretical foundations points to avenues for future research. 相似文献
110.
Marie Robin Kavita Raj Sylvie Chevret Jordan Gauthier Hugues de Lavallade David Michonneau Donal McLornan Régis Peffault de Latour Victoria Potter Austin Kulasekararaj Flore Sicre de Fontbrune Antonio Pagliuca Ibrahim Yakoub‐Agha Gérard Socié Ghulam J. Mufti 《European journal of haematology》2018,101(4):466-474