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排序方式: 共有167条查询结果,搜索用时 15 毫秒
91.
92.
Four patients with 5 nonopaque renal calculi composed of uric acid were examined by ultrasound. The calculi varied in size from a 1.5 X 1.5-cm intrapelvic stone to a staghorn calculus measuring 4 cm. All stones were satisfactorily imaged by ultrasound, allowing a diagnosis of nephrolithiasis to be made with confidence in each case. In 2 patients with poor excretion on urography, the diagnosis was not suspected prior to the ultrasound examination. The authors feel that ultrasound has great potential value in the investigation of nonopaque filling defects of the renal pelvis and in patients with urographic nonvisualization who have a high risk of uric acid lithiasis. 相似文献
93.
Intrahepatic amebic abscesses: indications for and results of percutaneous catheter drainage 总被引:2,自引:0,他引:2
vanSonnenberg E; Mueller PR; Schiffman HR; Ferrucci JT Jr; Casola G; Simeone JF; Cabrera OA; Gosink BB 《Radiology》1985,156(3):631-635
Medical therapy is standard for intrahepatic amebic abscess and generally is effective. However, we have encountered a group of patients in whom percutaneous aspiration and drainage was indicated due to uncertainty of diagnosis or clinical deterioration of the patient. Twenty such patients underwent percutaneous drainage with ultrasound or CT guidance, and each patient was cured (appropriate antibiotics were administered concomitantly). The specific indications for intervention were to differentiate pyogenic from amebic abscess, pain and imminent rupture, poor response to medical therapy, false-negative results of serologic tests, noncompliance with medical treatment, left lobe abscess, and pregnancy. Diagnosis of amebiasis from examination of the fluid was seldom possible, while findings from core biopsy of the wall of the abscess led to diagnosis in three cases. Recurrence necessitating redrainage occurred in three patients; in each, catheters were removed the same day drainage was performed. There were three minor complications. Differences from percutaneous management of pyogenic abscesses included more rapid removal of catheters (four days), more frequent use of US guidance, and more common use of the prone angled approach to avoid pleural contamination. Catheter drainage may be curative and may expedite care for problematic amebic liver abscesses in selected cases. 相似文献
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97.
N'-(3'-Monophospho-deoxyguanosin-8-yl)-N-acetylbenzidine (dGp-ABZ) is
thought to play an important role in initiation of benzidine-induced
bladder cancer in humans. This report assesses the possible formation of
this adduct by peroxidatic activation of N-acetylbenzidine (ABZ). Adduct
formation was measured by 32P-post-labeling. Ram seminal vesicle microsomes
were used as a source of prostaglandin H synthase (PHS). The peroxidatic
activity of PHS was compared with that for horseradish peroxidase. Both
peroxidases converted ABZ to dGp-ABZ whether DNA or 2'- deoxyguanosine
3'-monophosphate (dGp) was present. Following 32P-post- labeling, the
enzymatic and synthetic adduct were extracted from PEI- cellulose plates
and were shown to have the same HPLC elution profiles for the bisphosphate
adduct (32P-dpGp-ABZ). Treatment of the enzymatic and synthetic
bisphosphate adduct with nuclease P1 yielded a product that eluted at the
same time from the HPLC (32P-dpG-ABZ). Additional experiments demonstrated
that the PHS-derived 5'-monophosphate (dpG- ABZ) and 3'-monophosphate
(dGp-ABZ) adducts were also identical to their corresponding synthetic
standard. With comparable amounts of total ABZ metabolism, PHS produced
approximately 40-fold more dGp-ABZ than horseradish peroxidase (1943 +/-
339 versus 49 +/- 7.8 fmol/mg dGp). Adduct formation was dependent upon the
presence of peroxidase and the specific substrate, i.e. arachidonic acid or
H2O2. Adduct formation by PHS was inhibited by indomethacin (0.1 mM),
ascorbic acid (1 mM) and glutathione (10 mM), but not by
5,5-dimethyl-1-pyrroline N- oxide (DMPO) (100 mM), a radical scavenger.
Horseradish peroxidase adduct formation was also inhibited by ascorbic acid
and glutathione. In addition, DMPO elicited greater than a 96% inhibition.
Results demonstrate peroxidatic metabolism of ABZ to form dGp-ABZ. The
mechanism of dGp-ABZ formation by PHS and horseradish peroxidase may be
different.
相似文献
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Cole-Beuglet C; Soriano R; Kurtz AB; Meyer JE; Kopans DB; Goldberg BB 《Radiology》1983,146(2):481-486
100.
Characterization of reactions after transfusion of cellular blood components that are white cell reduced before storage 总被引:1,自引:0,他引:1
I Federowicz ; BB Barrett ; JW Andersen ; M Urashima ; MA Popovsky ; KC Anderson 《Transfusion》1996,36(1):21-28
Background: During the storage of cellular components before transfusion, cytokines that may mediate transfusion reactions are released from white cells (WBCs). Adverse effects of transfused cellular blood components therefore depend not only on the number of residual WBCs in blood components, but also on the timing of WBC reduction. Study Design and Methods: Febrile nonhemolytic transfusion reactions (FNHTRs), allergic reactions, and other reactions were characterized in recipients of 4728 units of red cells (RBCs) and 3405 bags of single-donor apheresis platelets (SDAPs), all of which underwent prestorage WBC reduction. To delineate the impact of prestorage versus poststorage WBC reduction of RBCs on transfusion reactions, these results were compared with reactions occurring after the transfusion to similar recipients of 6447 bags of RBCs that underwent poststorage WBC reduction by bedside filtration and 5197 units of SDAPs that underwent prestorage WBC reduction. The levels of interleukin (IL) 1 beta, IL-6, IL-8, and tumor necrosis factor-alpha (TNF-alpha) were measured in a subset of 20 implicated cellular blood components at the time of transfusion reactions and correlated with the duration of storage before transfusion. Results: The incidence of reactions was greater after transfusions of SDAPs (5.49%) than of RBCs (1.63%). The incidence of FNHTRs after transfusion of RBCs that were WBC reduced before storage (1.1%) was significantly lower (p = 0.0045) than that after transfusion of RBCs that were WBC reduced after storage (2.15%). Although allergic reactions to RBCs that were WBC reduced before storage were also less common (0.41%) than those to RBCs that were WBC reduced after storage (0.51%), the difference was not significant (p = 0.067). At the time of reactions to RBCs and SDAPs that were reduced before storage, the level of IL-6 was negatively correlated (r = -0.54, p = 0.014) with the duration of storage before transfusion, and there was no correlation between the level of either IL-1 beta or IL-8 and the interval before transfusion. TNF-alpha was not detectable in any implicated component. Conclusion: FNHTRs, but not allergic reactions, were less common after transfusion of RBCs that were WBC reduced before storage than after the transfusion of those WBC reduced after storage at the bedside by filtration. The level of IL-6 in implicated cellular blood components that were WBC reduced before storage was inversely correlated with the length of storage before transfusion. Further studies are needed to determine whether the transfusion of cellular blood components that were WBC reduced before storage can both diminish the incidence of adverse reactions and improve outcome. 相似文献