全文获取类型
收费全文 | 620篇 |
免费 | 28篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 6篇 |
妇产科学 | 26篇 |
基础医学 | 98篇 |
口腔科学 | 6篇 |
临床医学 | 54篇 |
内科学 | 129篇 |
皮肤病学 | 4篇 |
神经病学 | 60篇 |
特种医学 | 37篇 |
外科学 | 113篇 |
综合类 | 2篇 |
一般理论 | 1篇 |
预防医学 | 35篇 |
眼科学 | 13篇 |
药学 | 38篇 |
中国医学 | 3篇 |
肿瘤学 | 26篇 |
出版年
2023年 | 8篇 |
2022年 | 12篇 |
2021年 | 32篇 |
2020年 | 22篇 |
2019年 | 29篇 |
2018年 | 15篇 |
2017年 | 13篇 |
2016年 | 11篇 |
2015年 | 22篇 |
2014年 | 26篇 |
2013年 | 45篇 |
2012年 | 71篇 |
2011年 | 56篇 |
2010年 | 36篇 |
2009年 | 22篇 |
2008年 | 29篇 |
2007年 | 25篇 |
2006年 | 33篇 |
2005年 | 28篇 |
2004年 | 33篇 |
2003年 | 23篇 |
2002年 | 22篇 |
2001年 | 5篇 |
2000年 | 8篇 |
1999年 | 5篇 |
1998年 | 4篇 |
1997年 | 2篇 |
1996年 | 2篇 |
1994年 | 1篇 |
1991年 | 2篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 2篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1979年 | 1篇 |
1975年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有652条查询结果,搜索用时 500 毫秒
81.
82.
Lucía Gargiulo Sabrina Copsel Ezequiel M. Rivero Céline Galés Jean-Michel Sénard Isabel A. Lüthy Carlos Davio Ariana Bruzzone 《Oncotarget》2014,5(20):10058-10069
Breast cancer is the most frequent malignancy in women. Several reports demonstrated that adrenergic receptors (ARs) are involved in breast cancer. Here we observed that epinephrine (Epi), an endogenous AR agonist, caused opposite effects in non-tumorigenic (MCF-10A and HBL-100) and tumor cells (MCF-7 and MDA-MB-231). Thus, Epi, in non-tumor breast cells, as well as isoproterenol (β-agonist), in all cell lines, maintained a benign phenotype, decreasing cell proliferation and migration, and stimulating cell adhesion. β-AR expression and cAMP levels were higher in MCF-10A than in MCF-7 cells. β2-AR knock-down caused a significant increase of cell proliferation and migration, and a decrease of cell adhesion both in basal and in Iso-stimulated conditions. Coincidently, β2-AR over-expression induced a significant decrease of cell proliferation and migration, and an increase of cell adhesion. Therefore, β2-AR is implied in cell phenotype and its agonists or antagonists could eventually complement cancer therapy. 相似文献
83.
Martino DJ Strejilevich SA Scápola M Igoa A Marengo E Ais ED Perinot L 《Journal of affective disorders》2008,109(1-2):149-156
BACKGROUND: Nowadays it is not clear if in bipolar disorders (BD) cognitive impairments are heterogeneous and if so which are the variables that determine it. METHODS: Fifty patients with BD and thirty healthy controls were clinically evaluated including measures of obstetric complications history. All subjects completed an extensive neuropsychological battery selected to asses premorbid IQ and different cognitive domains. RESULTS: Compared with standardized norms, 38% of patients had none cognitive domain affected, while 40% had 1 to 2, and 22% had 3 to 5. Patients with cognitive functioning within normal limits had higher psychosocial functioning and premorbid IQ, and lower history of obstetric complications. LIMITATIONS: The small sample size could limit the generalizability of the results; since these data should be taken as preliminaries. CONCLUSIONS: The extension and severity of cognitive impairments may be heterogeneous in patients with BD, and it might contribute to explain the variability in functional outcome. Bipolar patients with low premorbid IQ and history of obstetric complications may represent a subgroup with lower cognitive performance and psychosocial functioning. 相似文献
84.
Maguire AM Simonelli F Pierce EA Pugh EN Mingozzi F Bennicelli J Banfi S Marshall KA Testa F Surace EM Rossi S Lyubarsky A Arruda VR Konkle B Stone E Sun J Jacobs J Dell'Osso L Hertle R Ma JX Redmond TM Zhu X Hauck B Zelenaia O Shindler KS Maguire MG Wright JF Volpe NJ McDonnell JW Auricchio A High KA Bennett J 《The New England journal of medicine》2008,358(21):2240-2248
Leber's congenital amaurosis (LCA) is a group of inherited blinding diseases with onset during childhood. One form of the disease, LCA2, is caused by mutations in the retinal pigment epithelium-specific 65-kDa protein gene (RPE65). We investigated the safety of subretinal delivery of a recombinant adeno-associated virus (AAV) carrying RPE65 complementary DNA (cDNA) (ClinicalTrials.gov number, NCT00516477 [ClinicalTrials.gov]). Three patients with LCA2 had an acceptable local and systemic adverse-event profile after delivery of AAV2.hRPE65v2. Each patient had a modest improvement in measures of retinal function on subjective tests of visual acuity. In one patient, an asymptomatic macular hole developed, and although the occurrence was considered to be an adverse event, the patient had some return of retinal function. Although the follow-up was very short and normal vision was not achieved, this study provides the basis for further gene therapy studies in patients with LCA. 相似文献
85.
Saasa N Sánchez-Hernández C de Lourdes Romero-Almaraz M Guerrero-Ibarra E Almazán-Catalán A Yoshida H Miyashita D Ishizuka M Sanada T Seto T Yoshii K Ramos C Yoshimatsu K Arikawa J Takashima I Kariwa H 《Virus research》2012,168(1-2):88-96
In our recent epidemiological survey conducted in Mexico for hantavirus infection, we identified three distinct viruses circulating in Mexican wild rodents, namely Montano virus (MTNV), Huitzilac virus (HUIV), and Carrizal virus (CARV). To gain a detailed understanding of hantavirus epidemiology and its associated hosts, 410 rodents were captured at eight collecting points in Morelos and Guerrero, Mexico, and examined for hantavirus seroprevalence, the presence of viral RNA, and rodent host species identification using cytochrome b gene sequences. Of the 32 species captured, seven species were positive for hantavirus: Peromyscus beatae (31/127; 24.4%), Reithrodontomys sumichrasti (6/15; 40%), Reithrodontomys megalotis (2/25; 8%), Peromyscus aztecus evides (1/1; 100%), Peromyscus megalops (1/41; 2.4%), Megadontomys thomasi (1/9; 11.1%), and Neotoma picta (1/6; 16.7%), with an overall prevalence of 10.5%; virus genome persisted in the majority of seropositive rodents. Nucleotide sequence and phylogenetic analysis showed that the viruses belonged mainly to the three lineages previously identified. The data showed that MTNV and CARV were primarily carried by P. beatae and R. sumichrasti, respectively. In addition, the data revealed an apparent complex interaction between hantaviruses and their hosts, suggesting active transmission and/or spillover infections within sympatric rodent species. 相似文献
86.
Dueñas JL Lete I Bermejo R Arbat A Pérez-Campos E Martínez-Salmeán J Serrano I Doval JL Coll C 《Contraception》2011,83(1):82-87
Background
This study was designed to acquire information about the use of contraceptive methods in order to reduce the number of elective abortions.Study Design
Since 1997, representative samples of Spanish women of childbearing potential (15–49 years) have been surveyed by the Daphne Team every 2 years to gather data of contraceptive methods used.Results
During the study period, 1997 to 2007, the overall use of contraceptive methods increased from 49.1% to 79.9%. The most commonly used method was the condom (an increase from 21% to 38.8%), followed by the pill (an increase from 14.2% to 20.3%). Female sterilization and IUDs decreased slightly and were used by less than 5% of women in 2007. The elective abortion rate increased from 5.52 to 11.49 per 1000 women.Conclusions
The factors responsible for the increased rate of elective abortion need further investigation. 相似文献87.
88.
89.
Jorge Garrido-Mantilla Alicia Lara Ezequiel Guardado Jose Lopez Joel Nerem Gustavo Pizarro Jean Paul Cano 《Transboundary and Emerging Diseases》2022,69(1):66-71
Porcine epidemic diarrhoea virus (PEDV) infects pigs of all ages causing vomiting and diarrhoea. PEDV is transmitted via the oral–faecal route, and a very low dose is enough to infect susceptible pigs, resulting in significant production losses. This short communication aims to describe the introduction of PEDV into a 10,000-sow farrow-to-wean farm located in northwest Mexico. Following the onset of clinical signs, an outbreak investigation was conducted to determine the most probable route of introduction. Based on data collected from interviews, construction of a timeline of events, and the detection of PEDV RNA in feed samples and samples collected from various surfaces of feed transport vehicles, it was concluded that the most probable route for PEDV incursion into this breeding herd was contaminated feed or a contaminated feed transport vehicle. This paper describes how feed or feed transport could serve as potential routes of PEDV infection to a farm and highlights the importance of establishing biosecurity programs to mitigate these risks. 相似文献
90.
Redondo Alfredo Paradela-Dobarro Beatriz Moscoso Isabel Moure-Álvarez María Cebro-Márquez María González-Juanatey José Ramón García-Seara Javier Álvarez Ezequiel 《Journal of molecular medicine (Berlin, Germany)》2021,99(7):955-956
Journal of Molecular Medicine - A Correction to this paper has been published: https://doi.org/10.1007/s00109-021-02062-6 相似文献