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51.
Maria Cristina Roberti Roberta La Starza Cecilia Surace Pietro Sirleto Rita Maria Pinto Valentina Pierini Barbara Crescenzi Cristina Mecucci Adriano Angioni 《Virchows Archiv : an international journal of pathology》2009,454(3):311-316
In this study, we report the molecular cytogenetic characterization of an acute myeloid leukemia with a der(Y)t(Y;1)(q12;q25)
in bone marrow cells in a child with Klinefelter syndrome. Conventional cytogenetics demonstrated the unbalanced translocation,
i.e., a trisomic 1q25-qter juxtaposed to Yq12 replaced the terminal segment of chromosome Y was acquired and present only
on bone marrow cells. Fluorescence in situ hybridization showed that the breakpoint at 1q25 disrupted RABGAP1L, a strongly expressed gene in CFU-GEMM, erythroid cells, and megakaryocytes, while the Yq12 breakpoint fell within the heterochromatic
region. As der(Y)t(Y;1)(q12;q25) was an isolated cytogenetic change, RABGAP1L rearrangement as well as gene(s) dosage effects correlated to 1q25-qter trisomy, and Yq12-qter loss may make a major contribution
to leukemogenesis and/or disease progression.
Maria Cristina Roberti and Roberta La Starza should be regarded as joint first authors. 相似文献
52.
Wera GD Dean CL Ahn UM Marcus RE Cassinelli EH Bohlman HH Ahn NU 《Journal of spinal disorders & techniques》2008,21(5):316-319
STUDY DESIGN: Retrospective review of 259 lumbar discectomies. OBJECTIVE: To compare rates of reoperation after subtotal discectomy versus established rates after fragment excision. SUMMARY OF BACKGROUND DATA: Herniated nucleus pulposes (HNP) and annular morphology influence rates of reherniation after discectomy. Certain patterns are linked to reherniation rates exceeding 20%. METHODS: We retrospectively reviewed 259 single-level lumbar discectomies performed between 1980 and 2005. Mean follow-up was 60.9 months. In each case, annulotomy and subtotal discectomy was performed in addition to excision of disc fragments. HNP morphology was classified according to the 4-part system of Carragee (type 1: fragment/fissure; type 2: fragment/defect; type 3: fragment/contained; type 4: no fragment/contained). Fisher exact test was used to compare our proportion of patients with reherniation and/or reoperation to Caragee's series in which only fragment excision was performed. RESULTS: Of 259 cases, 12 (4.5%) reoperations were performed. A significant difference in failure/reoperation rate was noted in type 2 herniations. There was a significantly lower rate of failure and reoperation for type 2 HNP after subtotal discectomy (3.4%) when compared with fragment excision alone (21.2%), P<0.003. CONCLUSIONS: Subtotal discectomy is an acceptable technique that decreases reherniation after lumbar discectomy. 相似文献
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Nowak W Goldschmidt ED Falcioni AG Pugliese MI Errasti AE Pelorosso FG Daray FM Gago JE Rothlin RP 《Naunyn-Schmiedeberg's archives of pharmacology》2007,375(3):221-229
It has been known for many years that plasma and tissues contain a variety of enzymes capable of metabolizing kinins. The
aim of the present study was to evaluate, by means of functional studies in a capacitance vessel such as the human umbilical
vein (HUV), the possible role played by the metallopeptidases angiotensin-converting enzyme (ACE), neutral endopeptidase (NEP),
and aminopeptidase M (APM) as an inactivating pathway of the B1 receptor endogenous agonist des-Arg10-kallidin (DAKD). In HUV rings with and without endothelium, concentration-response curves (CRCs) to DAKD were determined
after a 300-min incubation period, and enzymatic inhibitors were added to the organ baths 30 min before construction of the
CRC. Presence of endothelial layer was confirmed by histological studies. There was a significant leftward shift observed
in control HUV rings devoid of endothelium compared with intact tissues. Exposure to 1 μM captopril (ACE inhibitor) potentiated
DAKD-elicited vasoconstrictor responses in HUV rings with endothelium while no such effect was observed in tissues devoid
of endothelium. Application of 10 μM amastatin (APM inhibitor) induced a leftward shift of DAKD-elicited contractile responses
in HUV with and without endothelium. On the other hand, 10 μM phosphoramidon (NEP inhibitor) showed no potentiating effect
in HUV rings either with or without endothelium. However, under concurrent inhibition of ACE, NEP and APM, there was a higher
potentiation of DAKD-elicited contractile responses compared with the effect observed with combined inhibition of ACE and
APM. Moreover, when we evaluated contractile responses induced by Sar0-D-Phe8-des-Arg9-BK (a metabolically protected B1 receptor agonist), no potentiating effect was observed under triple enzymatic inhibition. In conclusion, in the present study
for the first time, we demonstrated in a capacitance vessel, HUV, that metallopeptidases ACE, NEP and APM represent a relevant
functional inactivation pathway of DAKD. 相似文献
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58.
Giannasi LC Matsui MT Batista SR Hardt CT Gomes CP Amorim JB Aguiar IC Collange L Oliveira EF Santos IR Dias IS Nassif SR Oliveira CS Oliveira LV Gomes MF 《BMC musculoskeletal disorders》2012,13(1):71
ABSTRACT: BACKGROUND: Few studies demonstrate effectiveness of therapies for oral rehabilitation of patients with cerebral palsy (CP), given the difficulties in chewing, swallowing and speech, besides the intellectual, sensory and social limitations. Due to upper airway obstruction, they are also vulnerable to sleep disorders. This study aims to assess the sleep variables, through polysomnography, and masticatory dynamics, using electromiography, before and after neuromuscular electrical stimulation, associated or not with low power laser (Gallium Arsenide- Aluminun, = 780nm) and LED ( = 660 nm) irradiation in CP patients. Methods/Design: 50 patients with CP, both gender, aged between 19 and 60 years will be enrolled in this study. The inclusion criteria are: voluntary participation, patient with hemiparesis, quadriparesis or diparetic CP, with ability to understand and respond to verbal commands. The exclusion criteria are: patients undergoing / underwent orthodontic, functional maxillary orthopedic or botulinum toxin treatment. Polysomnographic and surface electromyographic exams on masseter, temporalis and suprahyoid will be carry out in all sample. Questionnaire assessing oral characteristics will be applied. The sample will be divided into 5 treatment groups: Group 1: neuromuscular electrical stimulation; Group 2: laser therapy; Group 3: LED therapy; Group 4: neuromuscular electrical stimulation and laser therapy and Group 5: neuromuscular electrical stimulation and LED therapy. All patients will be treated during 8 consecutive weeks. After treatment, polysomnographic and electromiographic exams will be collected again. Discussion: This paper describes a five arm clinical trial assessing the examination of sleep quality and masticatory function in patients with CP under non-invasive therapies. 相似文献
59.
Gonçalves EM Silva AM Santos DA Lemos-Marini SH de Oliveira Santos A Mendes-Dos-Santos CT De-Mello MP Guerra-Júnior G 《Nutrition (Burbank, Los Angeles County, Calif.)》2012,28(10):984-990
ObjectiveThe use of anthropometric measurements to estimate the percentage of body fat (%BF) is easy and inexpensive. However, the accuracy of these methods in patients with 21-hydroxylase deficiency (21OHD) has not been explored. The objective of this study was to evaluate the accuracy of skinfold-based models, body mass index (BMI), and waist circumference (WC) in estimations of %BF using dual-energy X-ray absorptiometry (DXA) as the reference method in individuals with 21OHD.MethodsFifty-four 21OHD patients (32 women and 22 men), aged 7 to 20 y, were recruited for the study. DXA was used to determine %BF; four predictive skinfold equations, BMI, and WC were assessed for accuracy in determining %BF.ResultsAll predictive skinfold equations were highly associated (R, range: 0.82-0.89) with DXA %BF values. In women, BMI and WC showed moderate correlations (R = 0.69 for both BMI and WC) with DXA values. In contrast, among men there was a low explanatory power for BMI (13%) and WC (4%) and high errors (BMI, 6.9%; WC, 7.4%). All predictive equations significantly underestimated %BF (range of differences, ?4.1 to ?8.9) compared with DXA (women, 31.3 ± 6.1; men, 24.4 ± 7.3), and large limits of agreement were observed (range, ?15.3 to 1.7 and ?15.5 to 4.2 for women and men, respectively).ConclusionIn children and adolescents with 21OHD, %BF as estimated by skinfold measurements was associated more strongly with DXA-assessed %BF than both BMI and WC. However, still, the skinfold-based assessment underestimated DXA %BF and showed moderate agreement. 相似文献
60.
Two new conifer morphospecies represented by a secondary xylem are reported for the Lower Cretaceous Baqueró Group (Santa Cruz Province, Argentina). Agathoxylon sp. is characterized by poorly defined growth rings, predominantly uniseriate pitting in the radial wall of the tracheids, cross fields with 1-6 pits and uniseriate rays. These features are shared with the leafy branches described for the unit as Araucaria grandifolia Feruglio emend. Del Fueyo and Archangelsky. The second taxon, Brachyoxylon sp. cf. B. boureaui, possesses poorly defined growth rings, mixed wood with predominantly uniseriate radial pitting, cross fields with 8-26 pits and uniseriate rays. These taxa represent the first fossil woods described for Baqueroan strata. 相似文献