收费全文 | 5414篇 |
免费 | 375篇 |
国内免费 | 19篇 |
耳鼻咽喉 | 89篇 |
儿科学 | 200篇 |
妇产科学 | 63篇 |
基础医学 | 551篇 |
口腔科学 | 101篇 |
临床医学 | 431篇 |
内科学 | 1067篇 |
皮肤病学 | 148篇 |
神经病学 | 325篇 |
特种医学 | 221篇 |
外国民族医学 | 1篇 |
外科学 | 930篇 |
综合类 | 138篇 |
一般理论 | 6篇 |
预防医学 | 325篇 |
眼科学 | 152篇 |
药学 | 641篇 |
中国医学 | 40篇 |
肿瘤学 | 379篇 |
2023年 | 48篇 |
2022年 | 167篇 |
2021年 | 210篇 |
2020年 | 113篇 |
2019年 | 147篇 |
2018年 | 178篇 |
2017年 | 108篇 |
2016年 | 150篇 |
2015年 | 150篇 |
2014年 | 191篇 |
2013年 | 254篇 |
2012年 | 395篇 |
2011年 | 366篇 |
2010年 | 212篇 |
2009年 | 188篇 |
2008年 | 302篇 |
2007年 | 295篇 |
2006年 | 279篇 |
2005年 | 255篇 |
2004年 | 231篇 |
2003年 | 217篇 |
2002年 | 179篇 |
2001年 | 135篇 |
2000年 | 114篇 |
1999年 | 103篇 |
1998年 | 36篇 |
1997年 | 32篇 |
1996年 | 32篇 |
1995年 | 33篇 |
1994年 | 27篇 |
1993年 | 32篇 |
1992年 | 71篇 |
1991年 | 66篇 |
1990年 | 49篇 |
1989年 | 46篇 |
1988年 | 50篇 |
1987年 | 35篇 |
1986年 | 34篇 |
1985年 | 48篇 |
1984年 | 39篇 |
1983年 | 22篇 |
1982年 | 14篇 |
1981年 | 11篇 |
1979年 | 21篇 |
1978年 | 10篇 |
1974年 | 9篇 |
1973年 | 8篇 |
1972年 | 11篇 |
1971年 | 12篇 |
1968年 | 9篇 |
Patients with chronic cough are typically female and have a mean age of?~?60 years. However, initial pharmacokinetic (PK) characterization of the P2X3-receptor antagonist gefapixant, developed to treat refractory or unexplained chronic cough, was performed in healthy participants who were predominantly younger adult males. The objective of this Phase 1 study was to assess the safety, tolerability, and PK of gefapixant in younger (18–55 years) and older (65–80 years) males and females.
MethodsA randomized, double-blind, placebo-controlled study was conducted. Healthy adult participants were stratified into 4 cohorts by age and sex (younger males/females and older males/females) and randomized 4:1 (younger adults) or 3:1 (older adults) to receive gefapixant 300 mg twice daily (BID) for 1 week, followed by gefapixant 600 mg BID for 2 weeks or placebo. Safety, tolerability, and PK were assessed.
ResultsOf 36 randomized and treated participants, 28 (100%) receiving gefapixant and 6 (75%) receiving placebo reported?≥?1 adverse event (AE). The most common treatment-related AEs in the gefapixant group were taste related. Predefined renal/urologic AEs were reported by 7 (25%) participants receiving gefapixant (all mild to moderate in severity). Gefapixant exposure was generally lower in younger males compared with younger females and older adults; however, differences may have been due to estimated glomerular filtration rate.
ConclusionThe safety profile of gefapixant 300–600 mg BID was generally consistent with previous studies. Additional characterization of gefapixant PK as a function of age and sex using population PK modeling is warranted.
相似文献![点击此处可从《Pacing and clinical electrophysiology : PACE》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Purpose
Visual performance following toric intraocular lens implantation for cataract with moderate and severe astigmatism.Setting
Cataract services, Shroff Eye Centre, New Delhi, India.Design
Case series.Method
This prospective study included 64 eyes of 40 patients with more than 1.50 dioptre (D) of pre-existing corneal astigmatism undergoing phacoemulsification with implantation of the AcrySof® toric IntraOcular Lens (IOL). The unaided visual acuity (UCVA), best corrected visual acuity (BCVA), residual refractive sphere and refractive cylinders were evaluated. Toric IOL axis and alignment error was measured by slit lamp method and Adobe Photoshop (version 7) method. Patient satisfaction was evaluated using a satisfaction questionnaire at 3 months.Results
The mean residual refractive astigmatism was 0.57 D at the final follow-up of 3 months. Mean alignment error was 3.44 degrees (SD = 2.60) by slit lamp method and 3.88 degrees (SD = 2.86) by Photoshop method. Forty-six (71.9%) eyes showed misalignment of 5 degrees or less, and 60 (93.8%) eyes showed misalignment of 10 degrees or less. The mean log MAR UCVA at 1st post-op day was 0.172 (SD = 0.02), on 7th post-op day was 0.138 (SD = 0.11), and on 30th post-op day was 0.081 (SD = 0.11). The mean log MAR BCVA at three months was −0.04 (SD = 0.76).Conclusion
We believe that implantation of AcrySof® toric IOL is an effective, safe and predictable method to correct high amounts of corneal astigmatism during cataract surgery. 相似文献Long-acting reversible contraceptives, such as the intrauterine device (IUD), remain underutilised in Pakistan with high discontinuation rates. Based on a 24-month prospective client follow-up (nested within a larger quasi-experimental study), this paper presents the comparison of two intervention models, one using private mid-level providers branded as “Suraj” and the other using community midwives (CMWs) of Maternal Newborn and Child Health Programme, for method continuation among IUD users. Moreover, determinants of IUD continuation and the reasons for discontinuation, and switching behaviour were studied within each arm.
MethodsA total of 1,163 IUD users, 824 from Suraj and 339 from the CMW model, were enrolled in this 24-month prospective client follow-up. Participants were followed-up by female community mobilisers physically every second month to ascertain continued IUD usage and to collect information on associated factors, switching behaviour, reasons for discontinuation, and pregnancy occurrence. The probabilities of IUD continuation and the risk factors for discontinuation were estimated by life table analysis and Cox proportional-hazard techniques, respectively.
ResultsThe cumulative probabilities of IUD continuation at 24 months in Suraj and CMW models were 82% and 80%, respectively. The difference between the two intervention areas was not significant. The probability distributions of IUD continuation were also similar in both interventions (Log rank test: χ2 = 0.06, df = 1, P = 0.81; Breslow test: χ2 = 0.6, df = 1, P = 0.44). Health concerns (Suraj = 57.1%, CMW = 38.7%) and pregnancy desire (Suraj = 29.3%, CMW = 40.3%) were reported as the most prominent reasons for IUD discontinuation in both intervention arms. IUD discontinuation was significantly associated with place of residence in Suraj and with age (15–25 years) in the CMW model.
ConclusionCMWs and private providers are equally capable of providing quality IUD services and ensuring higher method continuation. Pakistan’s National Maternal Newborn and Child Health programme should consider training CMWs and providing IUDs through them. Moreover, private sector mid-level providers could be engaged in promoting the use of IUDs.
相似文献