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排序方式: 共有775条查询结果,搜索用时 250 毫秒
81.
W Oh DK Stevenson JE Tyson BH Morris CE Ahlfors G Jesse Bender RJ Wong R Perritt BR Vohr KP Van Meurs HJ Vreman A Das DL Phelps T Michael O’Shea RD Higgins 《Acta paediatrica (Oslo, Norway : 1992)》2010,99(5):673-678
Objectives: To assess the influence of clinical status on the association between total plasma bilirubin and unbound bilirubin on death or adverse neurodevelopmental outcomes at 18–22 months corrected age in extremely low birth weight infants. Method: Total plasma bilirubin and unbound bilirubin were measured in 1101 extremely low birth weight infants at 5 ± 1 days of age. Clinical criteria were used to classify infants as clinically stable or unstable. Survivors were examined at 18–22 months corrected age by certified examiners. Outcome variables were death or neurodevelopmental impairment, death or cerebral palsy, death or hearing loss, and death prior to follow‐up. For all outcomes, the interaction between bilirubin variables and clinical status was assessed in logistic regression analyses adjusted for multiple risk factors. Results: Regardless of clinical status, an increasing level of unbound bilirubin was associated with higher rates of death or neurodevelopmental impairment, death or cerebral palsy, death or hearing loss and death before follow‐up. Total plasma bilirubin values were directly associated with death or neurodevelopmental impairment, death or cerebral palsy, death or hearing loss, and death before follow‐up in unstable infants, but not in stable infants. An inverse association between total plasma bilirubin and death or cerebral palsy was found in stable infants. Conclusions: In extremely low birth weight infants, clinical status at 5 days of age affects the association between total plasma bilirubin and death or adverse neurodevelopmental outcomes at 18–22 months of corrected age. An increasing level of UB is associated a higher risk of death or adverse neurodevelopmental outcomes regardless of clinical status. Increasing levels of total plasma bilirubin are directly associated with increasing risk of death or adverse neurodevelopmental outcomes in unstable, but not in stable infants. 相似文献
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M. Oechsner C. Buhmann J. Strauss H. J. Stuerenburg 《Journal of neural transmission (Vienna, Austria : 1996)》2002,109(1):69-75
Summary. Inhibition of the catechol-O-methyltransferase (COMT) is an effective treatment for end-of-dose fluctuations in advanced
Parkinson's disease. The aim of the present investigation was to analyse the consequences of subsequent alterations in levodopa
metabolism under common treat-ment conditions when the levodopa dose is adjusted due to the occurrence of dyskinesias after
initiation of the COMT-inhibitor. Ten patients with advanced Parkinson's disease (Hoehn & Yahr stage IV) were medicated with
tolcapone. Prior to and five to ten days after the initiation of tolca-pone 300 mg/d, serum level profiles of levodopa and
its metabolites (3-O-methyldopa (3-OMD), dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)) were performed. The
mean daily levodopa dose was reduced from 894 ± 248 mg to 646 ± 252 mg (p = 0.003). There was a significant increase in the
area under the curve (AUC) of DOPAC during COMT-inhibition compared to the baseline profile (p = 0.009). There were significant
decreases of the AUC of HAV (p = 0.001) and the ratios of the AUC HVA / AUC DOPAC (p = 0.0001) and AUC 3-OMD / AUC levodopa
(p = 0.0001). Conclusion: The elevation of DOPAC and the decrease of HVA and HVA / DOPAC reflect a shift of the levodopa metabolism
towards the MAO-B dependent oxidative pathway. This might contribute to production of hydroxyl radicals and induction of oxidative
stress.
Received July 9, 2001; accepted September 28, 2001 相似文献
84.
A 59-year-old white woman with temporal arteritis developed progressive renal failure. Renal biopsy results showed focal and segmental necrotizing glomerulonephritis; furthermore, giant cells were present in the destructed vessel walls. Immunosuppressive therapy did not prevent terminal renal failure. This case shows that renal involvement may be a feature of temporal arteritis. 相似文献
85.
86.
CT-guided intraarterial chemotherapy in locally advanced tumors 总被引:1,自引:0,他引:1
Gorich J; Rilinger N; Sokiranski R; Vogel J; Wikstrom M; Kramer S; Merkle E; Rieber A; Brambs HJ 《Radiology》1996,199(2):567
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We investigated the possible effect of age on the metabolism of androgens in muscle biopsies from patients with neuromuscular diseases. The conversion of testosterone, dihydrotestosterone (DHT) and 5-alpha-androstane-3-alpha-17-beta-diol (3-alpha-androstanediol) was measured in muscle biopsies from 24 patients with neuromuscular diseases and seven controls. The reductive metabolism of 3-alpha-HSDH was significantly higher than the oxidative metabolism. Significant metabolism of testosterone to DHT was not found. Only the age of the patients emerged as a significant negative predictor in a stepwise multiple linear regression model for V(max) and K(m) (Lineweaver-Burke plots) of the reductive metabolism of 3-alpha-HSDH. Therefore, altered metabolism of anabolic androgens in skeletal muscles could be demonstrated. We conclude that this could alter the androgenic catabolic/anabolic balance in the (androgenic target organ) skeletal muscle. 相似文献
90.