全文获取类型
收费全文 | 28708篇 |
免费 | 2271篇 |
国内免费 | 82篇 |
专业分类
耳鼻咽喉 | 244篇 |
儿科学 | 769篇 |
妇产科学 | 689篇 |
基础医学 | 4180篇 |
口腔科学 | 380篇 |
临床医学 | 2906篇 |
内科学 | 5623篇 |
皮肤病学 | 329篇 |
神经病学 | 2631篇 |
特种医学 | 673篇 |
外国民族医学 | 3篇 |
外科学 | 3992篇 |
综合类 | 547篇 |
一般理论 | 42篇 |
预防医学 | 2557篇 |
眼科学 | 892篇 |
药学 | 2371篇 |
中国医学 | 37篇 |
肿瘤学 | 2196篇 |
出版年
2023年 | 173篇 |
2022年 | 229篇 |
2021年 | 615篇 |
2020年 | 391篇 |
2019年 | 634篇 |
2018年 | 643篇 |
2017年 | 490篇 |
2016年 | 596篇 |
2015年 | 700篇 |
2014年 | 990篇 |
2013年 | 1446篇 |
2012年 | 2026篇 |
2011年 | 2146篇 |
2010年 | 1215篇 |
2009年 | 1056篇 |
2008年 | 1766篇 |
2007年 | 1906篇 |
2006年 | 1945篇 |
2005年 | 1938篇 |
2004年 | 1901篇 |
2003年 | 1655篇 |
2002年 | 1539篇 |
2001年 | 274篇 |
2000年 | 240篇 |
1999年 | 294篇 |
1998年 | 355篇 |
1997年 | 307篇 |
1996年 | 289篇 |
1995年 | 279篇 |
1994年 | 221篇 |
1993年 | 234篇 |
1992年 | 186篇 |
1991年 | 160篇 |
1990年 | 139篇 |
1989年 | 140篇 |
1988年 | 135篇 |
1987年 | 113篇 |
1986年 | 114篇 |
1985年 | 123篇 |
1984年 | 114篇 |
1983年 | 115篇 |
1982年 | 142篇 |
1981年 | 132篇 |
1980年 | 100篇 |
1979年 | 59篇 |
1978年 | 64篇 |
1977年 | 67篇 |
1976年 | 63篇 |
1974年 | 59篇 |
1973年 | 51篇 |
排序方式: 共有10000条查询结果,搜索用时 8 毫秒
991.
992.
993.
Chris‐Tin Cheng Jessica M. Deitch Ian E. Haines David J. Porter Sharon L. Kilbreath 《ANZ journal of surgery》2014,84(7-8):510-514
Lymphoedema of the arm is a potentially serious consequence of any axillary procedure performed during the management of breast cancer. In an attempt to reduce its incidence and severity, patients are instructed to avoid venepunctures and blood pressure measurements on the treated arm. These precautions are not possible in some patients and attempts to adhere to them can cause discomfort, anxiety and stress for both patients and their health‐care workers. The strength with which these recommendations are made is in contrast to the level of evidence underpinning them. This paper reviews this evidence regarding the safety, or lack thereof, of blood pressure monitoring and intravenous puncture in women who have had axillary surgery. With this evidence generally being anecdotal in nature, there appears to be no rigorous evidence‐based support for the risk‐reduction behaviours of avoiding blood pressure monitoring and venepuncture in the affected arm in the prevention of lymphoedema after axillary procedure. A clinical trial was proposed to investigate whether such avoidance measures were valuable, but failed during its inception. There remains a need for research from prospective trials on this controversial topic to determine the most appropriate patient recommendations that should be provided after axillary procedure regarding the risks for development of lymphoedema. 相似文献
994.
995.
Adenocarcinoma, neuroendocrine tumours, sarcomas and lymphomas are the four most common malignant tumours arising in the small intestine, although over forty different histological subtypes are described. Collectively these account for only 2% of cancers of the digestive system. The incidence of small bowel cancer has increased in recent decades with a four-fold increase in carcinoid tumours. Risk factors for small bowel tumours include coeliac disease, inflammatory bowel disease and a number of genetic abnormalities. The non-specific nature of their symptoms and the difficulty in visualising these tumours with normal endoscopic techniques often results in late diagnosis. Furthermore the paucity of literature on this topic has made it difficult to standardise management. There has however been marked improvement in imaging methods resulting in earlier diagnosis in many cases. As expected, early detection of localised, well differentiated tumours followed by surgical resection with negative margins offers the best chance of long term survival. Better adjuvant treatment, notably for gastrointestinal stromal tumours, has improved 5-year survival rates significantly. Development of surveillance guidelines for at risk populations may be a valuable way of improving early diagnosis of this challenging group of conditions. 相似文献
996.
Macey L. Murray Yingfen Hsia Karen Glaser Emily Simonoff Declan G. M. Murphy Philip J. Asherson Hanna Eklund Ian C. K. Wong 《Psychopharmacology》2014,231(6):1011-1021
Rationale
Autism spectrum disorders (ASDs) affect 1 % of children, having significant impact on health and social outcomes. Psychotropic medication use by individuals with ASD in the USA increased over time, and polypharmacy occurred in >50 % of those prescribed. In the UK, no psychotropic drugs are approved in ASDs, and little is known about patterns of pharmacological treatment in the ASD population and associated co-morbidities.Methods
We used The Health Improvement Network, a nationally representative primary care database, to assess the prevalence of ASD diagnoses, psychotropic drug prescribing and neuropsychiatric co-morbidities of 0–24 year olds between 1992 and 2008.Results
ASD prevalence increased 65-fold from 0.01 % (1992) to 0.50 % (2008). Psychotropic drugs were prescribed to 29 % (1,619/5,651) of the ASD cohort; the most prescribed drugs were sleep medication (9.7 % of prescribed patients), psychostimulants (7.9 %) and antipsychotics (7.3 %). More patients were given psychostimulants and sleep medications over time from 1.5–6.3 % and 2.2–5.9 % respectively. Thirty-seven per cent of the cohort had ≥1 record of a neuropsychiatric co-morbidity, the most common being developmental difficulties and learning disabilities (12.6 %), behavioural, conduct and personality disorders (11.1 %) and attention deficit hyperactivity disorder (7.5 %).Conclusions
British physicians are more conservative in prescribing practice than American colleagues. However, use of psychostimulants and antipsychotics is much higher in those with ASD than in the general population. Polypharmacy was seen in 34 % of prescribed patients in 2008. Additional studies examining use, efficacy, and long-term safety of antipsychotics and psychostimulants in autistic individuals are warranted. 相似文献997.
998.
999.
Sunil Veeravalli Bilal A. Omar Lyndsey Houseman Matthew Hancock Sandra G. Gonzalez Malagon Flora Scott Azara Janmohamed Ian R. Phillips Elizabeth A. Shephard 《Biochemical pharmacology》2014
Flavin-containing monooxygenases (FMOs) of mammals are thought to be involved exclusively in the metabolism of foreign chemicals. Here, we report the unexpected finding that mice lacking Fmos 1, 2 and 4 exhibit a lean phenotype and, despite similar food intake, weigh less and store less triglyceride in white adipose tissue (WAT) than wild-type mice. This is a consequence of enhanced whole-body energy expenditure, due mostly to increased resting energy expenditure (REE). This is fuelled, in part, by increased fatty acid β-oxidation in skeletal muscle, which would contribute to depletion of lipid stores in WAT. The enhanced energy expenditure is attributed, in part, to an increased capacity for exercise. There is no evidence that the enhanced REE is due to increased adaptive thermogenesis; instead, our results are consistent with the operation in WAT of a futile energy cycle. In contrast to FMO2 and FMO4, FMO1 is highly expressed in metabolic tissues, including liver, kidney, WAT and BAT. This and other evidence implicates FMO1 as underlying the phenotype. The identification of a novel, previously unsuspected, role for FMO1 as a regulator of energy homeostasis establishes, for the first time, a role for a mammalian FMO in endogenous metabolism. Thus, FMO1 can no longer be considered to function exclusively as a xenobiotic-metabolizing enzyme. Consequently, chronic administration of drugs that are substrates for FMO1 would be expected to affect energy homeostasis, via competition for endogenous substrates, and, thus, have important implications for the general health of patients and their response to drug therapy. 相似文献
1000.
Fiona Sewell Kathryn Chapman Paul Baldrick David Brewster Alan Broadmeadow Paul Brown Leigh Ann Burns-Naas Janet Clarke Alex Constan Jessica Couch Oliver Czupalla Andy Danks Joseph DeGeorge Lolke de Haan Klaudia Hettinger Marilyn Hill Matthias Festag Abby Jacobs David Jacobson-Kram Stephan Kopytek Helga Lorenz Sophia Gry Moesgaard Emma Moore Markku Pasanen Rick Perry Ian Ragan Sally Robinson Petra M. Schmitt Brian Short Beatriz Silva Lima Diane Smith Sue Sparrow Yvette van Bekkum David Jones 《Regulatory toxicology and pharmacology : RTP》2014