全文获取类型
收费全文 | 85105篇 |
免费 | 6039篇 |
国内免费 | 333篇 |
专业分类
耳鼻咽喉 | 1084篇 |
儿科学 | 2011篇 |
妇产科学 | 1273篇 |
基础医学 | 10185篇 |
口腔科学 | 2046篇 |
临床医学 | 9475篇 |
内科学 | 17970篇 |
皮肤病学 | 1652篇 |
神经病学 | 7936篇 |
特种医学 | 2833篇 |
外科学 | 13604篇 |
综合类 | 1088篇 |
一般理论 | 94篇 |
预防医学 | 7091篇 |
眼科学 | 1623篇 |
药学 | 5622篇 |
3篇 | |
中国医学 | 82篇 |
肿瘤学 | 5805篇 |
出版年
2023年 | 385篇 |
2022年 | 635篇 |
2021年 | 1513篇 |
2020年 | 884篇 |
2019年 | 1517篇 |
2018年 | 1777篇 |
2017年 | 1349篇 |
2016年 | 1552篇 |
2015年 | 1739篇 |
2014年 | 2476篇 |
2013年 | 3552篇 |
2012年 | 5437篇 |
2011年 | 5861篇 |
2010年 | 3177篇 |
2009年 | 2952篇 |
2008年 | 5198篇 |
2007年 | 5376篇 |
2006年 | 5347篇 |
2005年 | 5379篇 |
2004年 | 5055篇 |
2003年 | 4809篇 |
2002年 | 4545篇 |
2001年 | 1404篇 |
2000年 | 1377篇 |
1999年 | 1369篇 |
1998年 | 1018篇 |
1997年 | 842篇 |
1996年 | 768篇 |
1995年 | 764篇 |
1994年 | 623篇 |
1993年 | 565篇 |
1992年 | 898篇 |
1991年 | 856篇 |
1990年 | 801篇 |
1989年 | 680篇 |
1988年 | 696篇 |
1987年 | 649篇 |
1986年 | 654篇 |
1985年 | 659篇 |
1984年 | 554篇 |
1983年 | 528篇 |
1982年 | 537篇 |
1981年 | 495篇 |
1980年 | 382篇 |
1979年 | 420篇 |
1978年 | 367篇 |
1977年 | 313篇 |
1976年 | 232篇 |
1974年 | 268篇 |
1973年 | 256篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
71.
72.
73.
74.
75.
Phase I study of high-dose cytosine arabinoside and etoposide in patients with advanced malignancies
Bayard L. Powell Hyman B. Muss Robert L. Capizzi Mary E. Caponera Douglas R. White Patricia J. Zekan James N. Atkins Don V. Jackson Jr. Frederick Richards II John B. Craig Julia M. Cruz Charles L. Spurr 《Cancer chemotherapy and pharmacology》1987,19(3):250-252
Summary Cytosine arabinsodie (ara-C) and etoposide (VP-16) display synergy in the laboratory. Twenty-six patients participated in a phase I study of high-dose ara-C in combination with VP-16. The dose of VP-16 was held constant at 50 mg/m2 as an intermittent infusion over 33 h; escalating doses of ara-C were given as infusions during hours 9–12 and 21–24. Myelosuppression was the dose-limiting toxicity and occurred with doses considerably less than those expected from studies of the two drugs as single agents. The suggested initial doses for phase II trials with this schedule are 750 mg/m2×2 doses of ara-C and 50 mg/m2 of VP-16. Nonhematologic toxicity was minimal; therefore, further dose escalation is feasible in patients in whom myelosuppression is acceptable.Supported in part by grants from the National Cancer Institute (CA-12197 and CA-09422) and the American Cancer Society CF-85-182 相似文献
76.
David C. Cone MD Susan M. Nedza MD MBA James J. Augustine MD Steven J. Davidson MD MBA 《Academic emergency medicine》2002,9(11):1085-1090
This paper reports the proceedings of the discussion panel assigned to look at clinical aspects of quality in emergency medicine. One of the seven stated objectives of the Academic Emergency Medicine consensus conference on quality in emergency medicine was to educate emergency physicians regarding quality measures and quality improvement as essential aspects of the practice of emergency medicine. Another topic of interest was a discussion of the value of information technology in facilitating quality care in the clinical practice of emergency medicine. It is important to note that this is not intended to be a comprehensive review of this extensive topic, but instead is designed to report the discussion that occurred at this session of the consensus conference. 相似文献
77.
Steven R. Jensen M.D. Dawn R. Voegeli John C. McDermott Andrew B. Crummy 《Cardiovascular and interventional radiology》1986,9(4):202-204
Eight lymphatic fluid collections were drained percutaneously. There were no immediate or late complications. Seven patients
had follow-up; 1 required surgical drainage of a residual or recurrent lymphocele, and another had reaccumulated fluid in
a lymphocele which was detected on autopsy. The remaining lymphatic collections responded to percutaneous drainage. Percutaneous
drainage is safe and can be an effective tool in the management of lymphatic collections. 相似文献
78.
Bernard P Halloran Virginia L Ferguson Steven J Simske Andrew Burghardt Laura L Venton Sharmila Majumdar 《Journal of bone and mineral research》2002,17(6):1044-1050
To determine whether the mouse loses bone with aging and whether the changes mimic those observed in human aging, we examined the changes in the tibial metaphysis and diaphysis in the male C57BL/6J mouse over its life span using microcomputed tomography (microCT). Cancellous bone volume fraction (BV/TV) decreased 60% between 6 weeks and 24 months of age. Loss was characterized by decreased trabecular number (Tb.N), increased trabecular spacing (Tb.Sp), and decreased connectivity. Anisotropy decreased while the structure model index increased with age. Cortical bone thickness increased between 6 weeks and 6 months of age and then decreased continuously to 24 months (-12%). Cortical bone area (Ct.Ar) remained constant between 6 and 24 months. Fat-free weight reached a peak at 12 months and gradually declined to 24 months. Total mass lost between 12 and 24 months reached 10%. Overall, the age-related changes in skeletal mass and architecture in the mouse were remarkably similar to those seen in human aging. Furthermore, the rapid early loss of cancellous bone suggests that bone loss is not just associated with old age in the mouse but rather occurs as a continuum from early growth. We conclude that the C57BL/6J male mouse maybe a useful model to study at least some aspects of age-related bone loss in humans. 相似文献
79.
Physiologic mechanism and preoperative prediction of new-onset dysphagia after laparoscopic Nissen fundoplication 总被引:2,自引:0,他引:2
Dennis Blom M.D. Jeffrey H. Peters M.D. Tom R. DeMeester M.D. Peter F. Crookes M.D. Jeffrey A. Hagan M.D. Steven R. DeMeester M.D. Cedric Bremner M.D. 《Journal of gastrointestinal surgery》2002,6(1):22-28
The aim of this study was to determine whether preoperative physiologic factors can account for and be used to predict the
development of postoperative dysphagia after laparoscopic Nissen fundoplication. One hundred sixty-three patients with gastroesophageal
reflux disease underwent laparoscopic Nissen fundoplication with a median follow-up of 14 months (range 6 to 81 months). Preoperative
dysphagia was present in 37% (60 of 163) and was relieved in all but five patients (92%). Female sex (P = 0.01) and the presence of a stricture (P = 0.02) were the only preoperative variables associated with the presence of preoperative dysphagia. Eight percent (8 of
103) of patients without preoperative dysphagia developed new-onset dysphagia, and of these 63% (5 of 8) had a normal lower
esophageal sphincter (LES) (pressure >6 mm Hg; length >2 cm; abdominal length >1 cm). New-onset dysphagia was significantly
more common in patients with a normal LES (22% [5 of 23] vs. 4% [3 of 80], P = 001). Patients with a normal LES had almost a sixfold increase in the risk of developing dysphagia as those with an abnormal
LES (relative risk = 5.8). Only a preoperative normal LES (P = 0.02) or mean LES pressures (P = 0.04) were positively associated with the development of postoperative dysphagia. The severity of this dysphagia also showed
a strong positive trend of increasing with mean preoperative LES pressures (P = 0.07). Finally, preoperative LES pressure significantly correlated with postoperative LES pressure (r = 0.48, P = 0.01) and with mean residual LES (nadir) pressure (r = 0.33, P = 0.05) offering insight into the mechanism of this dysphagia. In conclusion, preoperative LES parameters play a role in
the development of dysphagia after laparoscopic Nissen fundoplication. Patients with a normal LES or high mean LES pressures
are at increased risk for developing this complication and should be informed of this before laparoscopic Nissen fundoplication.
Presented at the Forty-Second Annual Meeting of The Society for Surgery of the Alimentary Tract, Atlanta, Ga., May 20–23,
2001. 相似文献
80.
Timothy J Halligan Nathan G Russell William J Dunn Steven J Caldroney Timothy B Skelton 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2005,100(6):688-692
Scurvy is a nondiscriminatory disease process resulting from a nutritional deficiency of ascorbic acid (vitamin C). The severe vitamin deficiency produces a breakdown in the cellular structure of the body. This case report describes a middle-age woman with a history of edema, bruising of the lower extremities, anemia, and severe periodontal disease. Her presentation and medical history are classic for the signs of scurvy. Scurvy is now only uncommonly seen in developed countries, but there are still vulnerable populations whose nutritional status can lead to scurvy. The aim of this report is to help the clinician identify and treat scurvy, a disease that was once feared for its high mortality but is now easily treatable, even in cases that have progressed to multiple organ dysfunction and failure. 相似文献