全文获取类型
收费全文 | 2430篇 |
免费 | 103篇 |
国内免费 | 86篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 78篇 |
妇产科学 | 29篇 |
基础医学 | 248篇 |
口腔科学 | 27篇 |
临床医学 | 287篇 |
内科学 | 625篇 |
皮肤病学 | 110篇 |
神经病学 | 137篇 |
特种医学 | 311篇 |
外科学 | 202篇 |
综合类 | 29篇 |
预防医学 | 64篇 |
眼科学 | 11篇 |
药学 | 143篇 |
中国医学 | 1篇 |
肿瘤学 | 306篇 |
出版年
2022年 | 13篇 |
2021年 | 28篇 |
2020年 | 13篇 |
2019年 | 45篇 |
2018年 | 53篇 |
2017年 | 32篇 |
2016年 | 31篇 |
2015年 | 41篇 |
2014年 | 40篇 |
2013年 | 73篇 |
2012年 | 94篇 |
2011年 | 69篇 |
2010年 | 95篇 |
2009年 | 85篇 |
2008年 | 66篇 |
2007年 | 102篇 |
2006年 | 72篇 |
2005年 | 75篇 |
2004年 | 68篇 |
2003年 | 65篇 |
2002年 | 60篇 |
2001年 | 62篇 |
2000年 | 69篇 |
1999年 | 69篇 |
1998年 | 104篇 |
1997年 | 97篇 |
1996年 | 119篇 |
1995年 | 90篇 |
1994年 | 95篇 |
1993年 | 80篇 |
1992年 | 45篇 |
1991年 | 59篇 |
1990年 | 50篇 |
1989年 | 52篇 |
1988年 | 50篇 |
1987年 | 39篇 |
1986年 | 38篇 |
1985年 | 46篇 |
1984年 | 18篇 |
1983年 | 25篇 |
1982年 | 24篇 |
1981年 | 23篇 |
1980年 | 22篇 |
1978年 | 12篇 |
1977年 | 22篇 |
1976年 | 18篇 |
1975年 | 11篇 |
1974年 | 14篇 |
1973年 | 10篇 |
1972年 | 9篇 |
排序方式: 共有2619条查询结果,搜索用时 0 毫秒
71.
High-dose intravenous gammaglobulin in alloimmunized platelet transfusion recipients 总被引:1,自引:1,他引:1
High-dose intravenous gammaglobulin (polyvalent immunoglobulin G) has been shown to be of benefit in some patients with immune thrombocytopenic purpura (ITP), possibly by producing reticuloendothelial system blockade. We studied this approach in patients refractory to random donor platelet transfusion using an IV IgG preparation manufactured by the Swiss Red Cross. Eleven adult patients with acute leukemia received either 0.4 g IgG/kg/d intravenously X five days (four patients) or 0.6 g/kg/d X five days (seven patients). All patients had high levels of lymphocytotoxic antibody and poor responses to random donor platelets. Except for mild headaches in two patients, there were no side effects related to the IgG infusions. All patients had significant elevations of serum IgG on the day after completion of treatment. Either random donor or partially HLA-matched platelet transfusions were administered the day after and, in some cases, during the IgG therapy. No patient had an improvement in one hour posttransfusion platelet count increments. Two additional patients received pooled platelet concentrates incubated for 30 minutes at 37 degrees C with IgG at a final concentration of 3 g% prior to transfusions. These results indicate that high-dose IgG, an extremely expensive treatment, cannot be recommended for alloimmunized adults with leukemia. 相似文献
72.
73.
Advances in biology have lead to the characterization of the molecular mechanisms underlying angiogenesis, a crucial process of tumor growth. Tumor cells secrete various growth factors, including VEGF, which activate endothelial cells to form new blood vessels. Numerous drugs, at present in clinical development, interfere with the molecular mediators of angiogenesis. The death of neovessels achieved by some of such compounds allows reduction in tumor size. This review describes many angiogenesic inhibitors which mechanisms of action are quite diverse. 相似文献
74.
Queenan JT Jr; Veeck LL; Toner JP; Oehninger S; Muasher SJ 《Human reproduction (Oxford, England)》1997,12(7):1573-1576
In-vitro fertilization patients (n = 15) at risk of ovarian
hyperstimulation syndrome (OHSS) (oestradiol > or =4500 pg/ml on the day
of human chorionic gonadotrophin administration and 25 or more follicles of
intermediate or large size) underwent aspiration of all follicles and
cryopreservation of all fertilized oocytes at the pronuclear stage.
Patients were monitored for up to 2 weeks post- retrieval. Subsequent
transfer of cryopreserved-thawed embryos was performed in programmed cycles
using exogenous oestrogen and progesterone for endometrial preparation. Two
patients (13%) developed OHSS necessitating hospitalization and vaginal
aspiration of ascitic fluid. Two other patients (13%) developed moderate
OHSS requiring ascitic fluid vaginal aspiration in the office setting, with
dramatic improvement of the condition. Subsequent transfer of
cryopreserved- thawed embryos yielded a clinical pregnancy rate of 58% per
transfer and ongoing or delivery rates of 42 and 67% per transfer and per
patient respectively. By eliminating pregnancy potential with
cryopreservation of all prezygotes and examining the pregnancy potential
with subsequent cryopreserved-thawed transfers, it is concluded that OHSS
is reduced, but not eliminated for patients at risk. Subsequent transfer of
cryopreserved-thawed prezygotes in a programmed cycle with exogenous
steroids yields an excellent pregnancy rate.
相似文献
75.
Erik P A van Iperen Suthesh Sivapalaratnam S Matthijs Boekholdt G Kees Hovingh Stephanie Maiwald Michael W Tanck Nicole Soranzo Jonathan C Stephens Jennifer G Sambrook Marcel Levi Willem H Ouwehand John JP Kastelein Mieke D Trip Aeilko H Zwinderman 《European journal of human genetics : EJHG》2014,22(6):809-813
In recent years, multiple loci dispersed on the genome have been shown to be associated with coronary artery disease (CAD). We investigated whether these common genetic variants also hold value for CAD prediction in a large cohort of patients with familial hypercholesterolemia (FH). We genotyped a total of 41 single-nucleotide polymorphisms (SNPs) in 1701 FH patients, of whom 482 patients (28.3%) had at least one coronary event during an average follow up of 66 years. The association of each SNP with event-free survival time was calculated with a Cox proportional hazard model. In the cardiovascular disease risk factor adjusted analysis, the most significant SNP was rs1122608:G>T in the SMARCA4 gene near the LDL-receptor (LDLR) gene, with a hazard ratio for CAD risk of 0.74 (95% CI 0.49–0.99; P-value 0.021). However, none of the SNPs reached the Bonferroni threshold. Of all the known CAD loci analyzed, the SMARCA4 locus near the LDLR had the strongest negative association with CAD in this high-risk FH cohort. The effect is contrary to what was expected. None of the other loci showed association with CAD. 相似文献
76.
F. Amat A. Soria P. Tallon M. Bourgoin‐Heck N. Lambert A. Deschildre J. Just 《Clinical and experimental allergy》2018,48(8):919-934
Atopic dermatitis (AD) is a complex disease with multiple causes and complex mechanistic pathways according to age of onset, severity of the illness, ethnic modifiers, response to therapy and triggers. A group of difficult‐to‐manage patients characterized by early‐onset AD and severe lifelong disease associated with allergic asthma and/or food allergy (FA) has been identified. In this study, we focus on these severe phenotypes, analysing their links with other atopic comorbidities, and taking into account the results from recent cohort studies and meta‐analyses. The main hypothesis that is currently proposed to explain the onset of allergic diseases is an epithelial barrier defect. Thus, the atopic march could correspond to an epithelial dysfunction, self‐sustained by a secondary allergenic sensitization, explaining the transition from AD to allergic asthma. Furthermore, AD severity seems to be a risk factor for associated FA. Results from population‐based, birth and patient cohorts show that early‐onset and severe AD, male gender, parental history of asthma, and early and multiple sensitizations are risk factors leading to the atopic march and the development of asthma. The importance of environmental factors should be recognized in these high‐risk children and prevention programs adapted accordingly. Effective targeted therapies to restore both barrier function and to control inflammation are necessary; early emollient therapy is an important approach to prevent AD in high‐risk children. Clinicians should also keep in mind the specific risk of atopic comorbidities in case of filaggrin loss‐of‐function mutations and the rare phenotypes of orphan syndromes due to heritable mutations in skin barrier components. 相似文献
77.
BDSS Budagoda KAS Kodikara WKS Kularatne RM Mudiyanse DH Edussuriya JP Edirisinghe IP Karunaratne KGAD Weerakoon SC Medagedara SAM Kularatne 《Asian Pacific journal of tropical medicine》2010,3(7):586-588
The sting of Giant Asian honeybee (Apis dorsata) or Bambara in Sinhala and Karunge Kulavi in Tamil is a common environmental hazard in Sri Lanka known to cause immediate allergic reactions, which could be fatal in sensitized individuals. We reported myocardial infarction, bowel gangrene and fatal anaphylaxis in a prospectively proven case series and the association of these uncommon complications with delayed removal of stingers from the patients' skin. 相似文献
78.
Linda M. Starnes Dan Su Laura M. Pikkupeura Brian T. Weinert Margarida A. Santos Andreas Mund Rebeca Soria Young-Wook Cho Irina Pozdnyakova Martina Kubec H?jfeldt Andrea Vala Wenjing Yang Blanca López-Méndez Ji-Eun Lee Weiqun Peng Joan Yuan Kai Ge Guillermo Montoya André Nussenzweig Chunaram Choudhary Jeremy A. Daniel 《Genes & development》2016,30(2):149-163
79.
80.
The GAP-related domain of tuberin, the product of the TSC2 gene, is a target for missense mutations in tuberous sclerosis 总被引:5,自引:0,他引:5
Maheshwar MM; Cheadle JP; Jones AC; Myring J; Fryer AE; Harris PC; Sampson JR 《Human molecular genetics》1997,6(11):1991-1996
Tuberous sclerosis is an autosomal dominant trait in which the
dysregulation of cellular proliferation and differentiation results in the
development of hamartomatous growths in many organs. The TSC2 gene is one
of two genes determining tuberous sclerosis. Inactivating germline
mutations of TSC2 in patients with tuberous sclerosis and somatic loss of
heterozygosity at the TSC2 locus in the associated hamartomas indicate that
TSC2 functions as a tumour suppressor gene and that loss of function is
critical to expression of the tuberous sclerosis phenotype. The TSC2
product, tuberin, has a region of homology with the GTPase activating
protein rap1GAP and stimulates the GTPase activity of rap1a and rab5a in
vitro. Here we show that the region of homology between tuberin and human
rap1GAP and the murine GAP mSpa1 is more extensive than previously reported
and spans approximately 160 amino acid residues encoded within exons 34-38
of the TSC2 gene. Single strand conformation polymorphism analysis of these
exons in 173 unrelated patients with tuberous sclerosis and direct
sequencing of variant conformers together with study of additional family
members enabled characterisation of disease associated mutations in 14
cases. Missense mutations, which occurred in exons 36, 37 and 38 were
identified in eight cases, four of whom shared the same recurrent change
P1675L. Each of the five different missense mutations identified was shown
to occur de novo in at least one sporadic case of tuberous sclerosis. The
high proportion of missense mutations detected in the region of the TSC2
gene encoding the GAP-related domain supports its key role in the
regulation of cellular growth.
相似文献