全文获取类型
收费全文 | 945篇 |
免费 | 69篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 20篇 |
妇产科学 | 21篇 |
基础医学 | 126篇 |
口腔科学 | 99篇 |
临床医学 | 81篇 |
内科学 | 216篇 |
皮肤病学 | 11篇 |
神经病学 | 130篇 |
特种医学 | 24篇 |
外科学 | 72篇 |
综合类 | 7篇 |
一般理论 | 1篇 |
预防医学 | 67篇 |
眼科学 | 26篇 |
药学 | 68篇 |
中国医学 | 1篇 |
肿瘤学 | 45篇 |
出版年
2024年 | 1篇 |
2023年 | 9篇 |
2022年 | 25篇 |
2021年 | 39篇 |
2020年 | 34篇 |
2019年 | 41篇 |
2018年 | 45篇 |
2017年 | 23篇 |
2016年 | 43篇 |
2015年 | 29篇 |
2014年 | 50篇 |
2013年 | 46篇 |
2012年 | 87篇 |
2011年 | 75篇 |
2010年 | 38篇 |
2009年 | 43篇 |
2008年 | 68篇 |
2007年 | 62篇 |
2006年 | 53篇 |
2005年 | 44篇 |
2004年 | 43篇 |
2003年 | 49篇 |
2002年 | 33篇 |
2001年 | 5篇 |
2000年 | 5篇 |
1999年 | 3篇 |
1998年 | 7篇 |
1997年 | 2篇 |
1996年 | 1篇 |
1995年 | 3篇 |
1994年 | 2篇 |
1990年 | 2篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1982年 | 1篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有1017条查询结果,搜索用时 15 毫秒
21.
van den Heuvel Leigh L. Ahmed-Leitao Fatima du Plessis Stefan Hoddinott Graeme Spies Georgina Seedat Soraya 《Journal of neurovirology》2022,28(4-6):514-526
Journal of NeuroVirology - The intersecting epidemics of HIV and hazardous or harmful alcohol use (HAU) can have significant detrimental consequences. Both HIV and HAU have independent negative... 相似文献
22.
Metabolic voxel‐based analysis of the complete human brain using fast 3D‐MRSI: Proof of concept in multiple sclerosis 下载免费PDF全文
Maxime Donadieu MS Yann Le Fur PhD Angèle Lecocq PhD Andrew A. Maudsley PhD Soraya Gherib MS Elisabeth Soulier BS Sylviane Confort‐Gouny PhD Fanelly Pariollaud PhD Marie‐Pierre Ranjeva PhD Jean Pelletier MD PhD Maxime Guye MD PhD Wafaa Zaaraoui PhD Bertrand Audoin MD PhD Jean‐Philippe Ranjeva PhD 《Journal of magnetic resonance imaging : JMRI》2016,44(2):411-419
23.
Hossein?Yazdekhasti Zahra?Rajabi Soraya?Parvari Mehdi?AbbasiEmail authorView authors OrcID profile 《Journal of ovarian research》2016,9(1):68
Although existence of ovarian stem cells (OSCs) in mammalian postnatal ovary is still under controversy, however, it has been almost accepted that OSCs are contributing actively to folliculogenesis and neo-oogenesis. Recently, various methods with different efficacies have been employed for OSCs isolation from ovarian tissue, which these methods could be chosen depends on aim of isolation and accessible equipments and materials in lab. Although isolated OSCs from different methods have various traits and characterizations, which might become from their different nature and origin, however these stem cells are promising source for woman infertility treatment or source of energy for women with a history of repeat IVF failure in near future. This review has brought together and summarized currently used protocols for isolation and propagation of OSCs in vitro. 相似文献
24.
Driouch K Landemaine T Sin S Wang S Lidereau R 《Clinical & experimental metastasis》2007,24(8):575-585
The advent of microarray tools has generated a massive amount of gene expression data. These data have greatly enhanced our understanding of the biology of breast cancer metastasis and provide a way to improve the prediction of the metastatic potential of breast tumours. Gene-expression profiling has highlighted the molecular heterogeneity of mammary tumours and contributed to the identification of a new molecular classification of breast cancers. In addition, several molecular signatures predicting the likelihood of distant metastases for breast cancer patients have been characterized. Further reports have described gene expression profiles associated with specific metastatic phenotypes, including the organ preference of breast cancer metastasis. Here we review the major studies that had important impacts on the understanding of breast cancer metastasis. We also discuss the future challenges in this research field and the special issues that still need to be examined. 相似文献
25.
26.
Nicolás Macías Soraya Abad Almudena Vega Santiago Cedeño Alba Santos Úrsula Verdalles Tania Linares Inés Aragoncillo Isabel Galán Ana García-Prieto José Luño Juan Manuel López Gómez 《Nefrología : publicación oficial de la Sociedad Espa?ola Nefrologia》2019,39(2):168-176
Background and objective
Online haemodiafiltration (OL-HDF) with high convective transport volumes improves patient survival in haemodialysis. Limiting the amount of convective volume has been proposed in patients with diabetes mellitus due to glucose load that is administered with replacement fluid. The objective of the study was to analyse the influence of substitution volume on the evolution of the metabolic profile and body composition of incident diabetic patients on OL-HDF.Material and methods
Prospective observational study in 29 incident diabetic patients on postdilution OL-HDF. Baseline data included clinical and demographic data, laboratory parameters (metabolic, nutritional and inflammatory profile) and body composition with bioimpedance spectroscopy (BIS). Laboratory parameters and mean substitution volume per session were collected every 4 months, and in 23 patients a further BIS was performed after a minimum of one year. Variations in glycosylated haemoglobin (HbA1c), triglycerides, total cholesterol, LDL-c, HDL-c, albumin, prealbumin and C reactive protein (CRP) were calculated at one year, 2 years, 3 years, and at the end of follow-up. Quarterly and annual variations were calculated as independent periods, and changes in body composition were analysed.Results
Age at baseline was 69.7 ± 13.6 years, 62.1% were male, 72.3 ± 13.9 kg, 1.78 ± 0.16 m2, with 48 (35.5-76) months on dialysis. Approximately 81.5% received insulin, 7.4% antidiabetic drugs and 51.9% statins. Mean substitution volume was 26.9 ± 2.9 L/session and follow-up period (time on OL-HDF) was 40.4 ± 26 months.A significant correlation was observed between mean substitution volume and the increase in HDL-c (r = 0.385, p = 0.039) and prealbumin levels (r = 0.404, p = 0.003) throughout follow-up. Moreover, substitution volume was correlated with a reduction in CRP levels at one year (r = –0.531, p = 0.005), 2 years (r = –0.463, p = 0.046), and at the end of follow-up (r = –0.498, p = 0.007). Patients with mean substitution volume > 26.9 L/session had a higher reduction in triglycerides and CRP, and an increase in HDL-c levels. These patients with > 26.9 L/session finished the study with higher HDL-c (48.1 ± 9.4 mg/dL vs. 41.2 ± 11.6 mg/dL, p = 0.025) and lower CRP levels (0.21 [0.1-2.22] mg/dL vs. 1.01 [0.15-6.96] mg/dL, p = 0.001), with no differences at baseline.Quarterly comparisons between substitution volume and laboratory changes [n = 271] showed a significant correlation with a reduction in HbA1c (r = –0.146, p = 0.021). Similar findings were obtained with annual comparisons [n = 72] (r = –0.237, p = 0.045). An annual mean substitution volume over 26.6 L/session (29.3 ± 1.7 L/session vs. 23.9 ± 1.9 L/session) was associated with a reduction in HbA1c (–0.51 ± 1.24% vs. 0.01 ± 0.88%, p = 0.043). No correlation was observed between substitution volume and changes in weight, body mass index or BIS parameters.Conclusion
There is not enough evidence to restrict convective transport in diabetic patients on OL-HDF due to the glucose content of the replacement fluid. 相似文献27.
Ana Carine Arruda Rolim Gracyelle Alves Remigio Moreira Sarah Maria Mendes Gondim Soraya da Silva Paz Luiza Jane Eyre de Souza Vieira 《Revista latino-americana de enfermagem》2014,22(6):1048-1055
OBJECTIVE:
to analyze the factors associated with the underreporting on the part of nurses within Primary Health Care of abuse against children and adolescents.METHOD:
cross-sectional study with 616 nurses. A questionnaire addressed socio-demographic data, profession, instrumentation and knowledge on the topic, identification and reporting of abuse cases. Bivariate and multivariate logistic regression was used.RESULTS:
female nurses, aged between 21 and 32 years old, not married, with five or more years since graduation, with graduate studies, and working for five or more years in PHC predominated. The final regression model showed that factors such as working for five or more years, having a reporting form within the PHC unit, and believing that reporting within Primary Health Care is an advantage, facilitate reporting.CONCLUSION:
the study''s results may, in addition to sensitizing nurses, support management professionals in establishing strategies intended to produce compliance with reporting as a legal device that ensures the rights of children and adolescents. 相似文献28.
29.
Assessment of the effect of a single oral dose of telithromycin on sotalol-induced qt interval prolongation in healthy women 下载免费PDF全文
Démolis JL Strabach S Vacheron F Funck-Brentano C 《British journal of clinical pharmacology》2005,60(2):120-127
AIMS: Telithromycin belongs to ketolides, a new class of macrolide antibiotics. Macrolides are known to have the potential to prolong QT interval duration. Previous studies have shown that telithromycin did not induce significant QT interval prolongation in healthy subjects compared with placebo. The main objective of this study was to demonstrate the absence of amplification of QT interval prolongation induced by sotalol, when telithromycin and sotalol were co-administered. The secondary objective was to correlate the QT interval changes induced by the study drugs to plasma concentrations during the elimination phase. METHODS: Twenty-four women received sotalol (160 mg) together with placebo or telithromycin (800 mg) in a two-period, double-blind, randomized study. Electrocardiograms were recorded at rest. Comparison of maximal corrected QT interval (QTc(max)) with sotalol in the presence or absence of telithromycin was performed. The relation between sotalol concentration and QTc was studied using linear regression. RESULTS: Mean difference (95% CI) between QTc(max) with sotalol-placebo and QTc(max) with sotalol-telithromycin was -15.5 ms (-27.7 to -3.2 ms). QTc(max) interval prolongation was lower (P < 0.05) with sotalol-telithromycin than with sotalol-placebo, in relation to decreased sotalol plasma concentrations. Regression analysis showed that the relationship between sotalol plasma concentration and QTc interval duration was not modified by telithromycin co-administration. CONCLUSION: Our results do not support a potential synergistic effect on QT interval prolongation between sotalol and telithromycin. The decrease of mean QTc interval in subjects taking telithromycin and sotalol may be explained by a decrease of sotalol concentration. 相似文献
30.
Depression and trauma are common among women living with HIV. This is the first study to track the longitudinal course of depression and examine the relationship between depression and trauma over time among women in South Africa. HIV-infected and uninfected women (N = 148) were assessed at baseline and one year later. Results of a path analysis show the multi-directional and entwined influence of early life stress, other life-threatening traumas across the lifespan, depression and PTSD over the course of HIV. We also observed higher rates of depressive symptomatology and more persistent cases among infected women compared to uninfected women, as well as a more consistent and enduring relationship between childhood trauma and depression among women living with HIV. The present study is unique in documenting the course of untreated depression and PTSD in women with and without HIV infection with a high prevalence of early childhood trauma. 相似文献