全文获取类型
收费全文 | 2733篇 |
免费 | 228篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 152篇 |
妇产科学 | 48篇 |
基础医学 | 412篇 |
口腔科学 | 71篇 |
临床医学 | 177篇 |
内科学 | 767篇 |
皮肤病学 | 40篇 |
神经病学 | 270篇 |
特种医学 | 79篇 |
外科学 | 349篇 |
综合类 | 16篇 |
预防医学 | 233篇 |
眼科学 | 34篇 |
药学 | 107篇 |
中国医学 | 9篇 |
肿瘤学 | 176篇 |
出版年
2023年 | 26篇 |
2022年 | 29篇 |
2021年 | 86篇 |
2020年 | 46篇 |
2019年 | 83篇 |
2018年 | 118篇 |
2017年 | 71篇 |
2016年 | 73篇 |
2015年 | 85篇 |
2014年 | 88篇 |
2013年 | 118篇 |
2012年 | 174篇 |
2011年 | 191篇 |
2010年 | 90篇 |
2009年 | 80篇 |
2008年 | 118篇 |
2007年 | 133篇 |
2006年 | 134篇 |
2005年 | 139篇 |
2004年 | 130篇 |
2003年 | 129篇 |
2002年 | 129篇 |
2001年 | 74篇 |
2000年 | 88篇 |
1999年 | 64篇 |
1998年 | 23篇 |
1997年 | 13篇 |
1996年 | 20篇 |
1995年 | 12篇 |
1994年 | 10篇 |
1993年 | 9篇 |
1992年 | 35篇 |
1991年 | 23篇 |
1990年 | 29篇 |
1989年 | 9篇 |
1988年 | 22篇 |
1987年 | 18篇 |
1986年 | 12篇 |
1985年 | 15篇 |
1984年 | 15篇 |
1983年 | 10篇 |
1978年 | 11篇 |
1977年 | 12篇 |
1976年 | 10篇 |
1975年 | 8篇 |
1970年 | 9篇 |
1969年 | 11篇 |
1968年 | 13篇 |
1967年 | 8篇 |
1962年 | 10篇 |
排序方式: 共有2965条查询结果,搜索用时 15 毫秒
101.
102.
A. de Pablo F. Santos A. Solé J.M. Borro J.M. Cifrian R. Laporta V. Monforte A. Román M. de la Torre P. Ussetti F. Zurbano 《Transplantation reviews (Orlando, Fla.)》2013,27(1):9-16
The antiproliferative effect of everolimus provides a therapeutic option in the immunosuppression therapy of lung transplantation, by reducing both the risk of acute rejection and the process of progressive fibrosis that determines chronic graft rejection. However, few data on the use of everolimus in lung transplantation have been published to date, and the specific indications of the drug, along with the most adequate time for its introduction or dosing, have not been defined yet.The aim of this article is to propose recommendations for the use of everolimus in lung transplant recipients, including indications, dosing schedules and the use of concomitant immunosuppression. This consensus document has been developed by experts of all the Spanish lung transplant groups from the review of the existing literature and the clinical experience. 相似文献
103.
Montserrat Solá MD José A. Alberro MD Manuel Fraile MD Pilar Santesteban MD Manuel Ramos MD Rafael Fabregas MD Antonio Moral MD Blas Ballester MD Sergi Vidal MD 《Annals of surgical oncology》2013,20(1):120-127
Background
It has been suggested that selective sentinel node (SN) biopsy alone can be used to manage early breast cancer, but definite evidence to support this notion is lacking. The aim of this study was to investigate whether refraining from completion axillary lymph node dissection (ALND) suffices to produce the same prognostic information and disease control as proceeding with completion ALND in early breast cancer patients showing micrometastasis at SN biopsy.Methods
This prospective, randomized clinical trial included patients with newly diagnosed early-stage breast cancer (T < 3.5 cm, clinical N0, M0) who underwent surgical excision as primary treatment. All had micrometastatic SN. Patients were randomly assigned to one of the two study arms: complete ALND (control arm) or clinical follow-up (experimental arm). Median follow-up was 5 years, recurrence was assessed, and the primary end point was disease-free survival.Results
From a total sample of 247 patients, 14 withdrew, leaving 112 in the control arm and 121 in the experimental arm. In 15 control subjects (13 %), completion ALND was positive, with a low tumor burden. Four patients experienced disease recurrence: 1 (1 %) of 108 control subjects and 3 (2.5 %) of 119 experimental patients. There were no differences in disease-free survival (p = 0.325) between arms and no cancer-related deaths.Conclusions
Our results strongly suggest that in early breast cancer patients with SN micrometastasis, selective SN lymphadenectomy suffices to control locoregional and distant disease, with no significant effects on survival. 相似文献104.
Elisabeth Coll Francisco Santos Pietat Ussetti Mercedes Canela José María Borro Mercedes De La Torre Andrés Varela Felipe Zurbano Roberto Mons Pilar Morales Juan Pastor Ángel Salvatierra Alicia de Pablo Pablo Gámez Antonio Moreno Juan Solé Antonio Román 《Archivos de bronconeumologia》2013,49(2):70-78
105.
María Sol Brassesco Luiz Guilherme Darrigo Jr Elvis Terci Valera Ricardo Santos Oliveira Yulie Aparecida Yamamoto Marcus Vinícius de Castro Barros Luiz Gonzaga Tone 《Child's nervous system》2013,29(8):1387-1390
Purpose
John Cunningham (JC) viral DNA sequence has seldom been reported in patients with brain tumors such as high grade gliomas and medulloblastomas, pointing to a role in the etiopathogenesis of such tumors.Results
We present a unique clinical case of an HIV-positive pediatric patient with multifocal leukoencephalopathy and confirmed JC virus (JCV) infection that developed a giant-cell glioblastoma.Conclusions
Experimental data with infected primates has previously hypothesized an association of human giant-cell glioblastoma with JCV or progressive multifocal leukoencephalopathy, though such association has not been documented in the literature for humans. Future studies with larger cohorts and molecular pathological analyses are still needed to corroborate the role of the widely spread human neurotropic virus in early transformation and in the development of brain tumors with different histology in the setting of HIV-related severe immunosuppression. 相似文献106.
Elvis Terci Valera Sabrine Teixeira Ferraz María Sol Brassesco Xiumei Zhen Yiping Shen Antonio Carlos dos Santos Luciano Neder Ricardo Santos Oliveira Carlos Alberto Scrideli Luiz Gonzaga Tone 《Child's nervous system》2013,29(12):2151-2155
Mowat–Wilson syndrome (MWS) is a rare genetic condition where variable and multiple congenital anomalies including Hirschsprung's disease, intellectual disability, and prominent facial features are present. At molecular level, MWS is characterized by many different described mutations in the zinc finger E-box protein 2 (ZEB2) gene, ultimately leading to loss of gene function. This report is the first to describe the association of MWS with two different asynchronous malignant brain tumors (medulloblastoma and glioblastoma) occurring in a child. 相似文献
107.
108.
Kim Dong Hyun Lee Han Sol Kwon Tae-Wan Han Young-Min Kang Nae-Won Lee Mee Yeon Kim Dae-Duk Kim Myeong Gyu Lee Jae-Young 《Archives of pharmacal research》2020,43(1):1-21
Archives of Pharmacal Research - The term “single enzyme nanoparticle” (SEN) refers to a chemically or biologically engineered single enzyme molecule. SENs are distinguished from... 相似文献
109.
110.