全文获取类型
收费全文 | 326篇 |
免费 | 17篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 8篇 |
妇产科学 | 1篇 |
基础医学 | 41篇 |
口腔科学 | 7篇 |
临床医学 | 23篇 |
内科学 | 66篇 |
皮肤病学 | 2篇 |
神经病学 | 25篇 |
特种医学 | 14篇 |
外科学 | 73篇 |
综合类 | 1篇 |
预防医学 | 28篇 |
眼科学 | 8篇 |
药学 | 26篇 |
中国医学 | 4篇 |
肿瘤学 | 14篇 |
出版年
2023年 | 2篇 |
2022年 | 12篇 |
2021年 | 15篇 |
2020年 | 21篇 |
2019年 | 16篇 |
2018年 | 21篇 |
2017年 | 10篇 |
2016年 | 10篇 |
2015年 | 10篇 |
2014年 | 15篇 |
2013年 | 17篇 |
2012年 | 24篇 |
2011年 | 18篇 |
2010年 | 10篇 |
2009年 | 10篇 |
2008年 | 17篇 |
2007年 | 13篇 |
2006年 | 17篇 |
2005年 | 16篇 |
2004年 | 14篇 |
2003年 | 16篇 |
2002年 | 13篇 |
2001年 | 2篇 |
2000年 | 1篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1995年 | 3篇 |
1994年 | 2篇 |
1993年 | 2篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1989年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 2篇 |
1978年 | 1篇 |
1975年 | 2篇 |
1930年 | 2篇 |
1929年 | 1篇 |
排序方式: 共有344条查询结果,搜索用时 640 毫秒
71.
Rahul Jain Anshita Arora Rohit Anand Shahzadi Malhotra Medha Mittal Monica Juneja 《Indian pediatrics》2017,54(7):550-555
Aim
To design and validate Hindi-language parent self-report developmental screening questionnaires for 9-month and 18-month-old Indian children.Design
Cross-sectional studySetting
Tertiary-care pediatric hospital from April 2014 to March 2016Participants
In each age group (9-month and 18-month), 45 children were enrolled for designing of questionnaires (30 for obtaining parental observations of current development and 15 for pre-testing). For validation of tool, 100 children (60 low risk and 40 high risk) were enrolled in each age group.Methods
For designing, observations regarding current developmental milestones were obtained from parents and a list of all enumerated milestones was prepared. After detailed discussion by a team of developmental pediatricians, pediatric resident, clinical psychologist and language specialist, milestones were chosen for drafting of questionnaires. In each age group, drafts were pre-tested and required modifications were done. The final questionnaires contained 20 items each to be scored on a Likert scale (total score ranging from 20 to 60, a lower score indicating a higher risk of developmental delay). These questionnaires were validated against Developmental Assessment Scale for Indian Infants (DASII), a gold standard instrument.Results
On ROC analysis, the 9-month and 18-month screening tool had area under curve of 0.988 and 0.953, respectively, for detecting developmental delay. Score ≤50 on the 9-months questionnaire had sensitivity of 100% and specificity of 87.2%. Score ≤49 on the 18-months questionnaire had sensitivity of 91.4% and specificity of 88.7%.Conclusions
The new questionnaires have a promising role in developmental screening of children at the time of routine immunizations in our country.72.
Sohrab S. Virk Dondrae Coble Alicia L. Bertone Hayam Hamaz Hussein Safdar N. Khan 《Journal of investigative surgery》2017,30(4):226-234
There are several animal models routinely used for study of the spinal fusion process and animal selection largely depends on the scientific question to be answered. This review outlines the advantages and disadvantages of various animal models used to study spinal fusion and describes the New Zealand White (NSW) rabbit which is the most popular preclinical model to study spinal fusion. We outline critical steps required in planning and performing spinal fusion surgery in this model. This includes determination of the required animal number to obtain statistical significance, an outline of appropriate technique for posterolateral fusion and other components of completing a study. As advances in drug delivery move forward and our understanding of the cascade of gene expression occurring during the fusion process grows, performing and interpreting preclinical animal models will be vital to validating new therapies to enhance spinal fusion. 相似文献
73.
Evaluation of various methods of biliary enteric anastomosis in benign biliary diseases (BBD). A surgeon operating for BBD needs to improve the internal drainage of bile to prevent stasis and its back-pressure effects. This is best obtained by biliary enteric anastomosis. A total of 121 cases of biliary enteric anastomosis in BBD were included in this study. The postoperative course and long-term outcome were studied prospectively. In the choledochoduodenostomy group, there were no leaks, no restrictures, and no mortality. Five (10.41 %) patients had cholangitis attacks and 2 (4.17 %) patients had sump syndrome. The choledochojejunostomy group had no leaks, no restrictures. Two (7.14 %) patients had repeated cholangitis and 2 (7.14 %) patients had sump syndrome, no mortality. The hepaticojejunostomy group had 3 cases of anastomotic leak of which 2 healed spontaneously and 1 needed resurgery. There was restricture in 2 cases, in which resurgery was successful—one death, no cholangiocarcinoma. Biliary enteric anastomosis is a safe and effective method for the management of BBD. The method should be selected according to the disease pathology and patient characteristics. 相似文献
74.
75.
Mohammad-Reza Zali M.D. Minoosh Vossoughi M.D. Homayoon Zojaji M.D. Amirhooshang M. Alizadeh M.D. Sohrab Aghabozorgi M.Sc. Sara Behrooz M.D. Seyed Javad Mirhassani Moghadam M.D. Mohammad Reza Azizi M.D. Rahim Aghazadeh M.D. Babak Noorinayer M.D. 《The American journal of gastroenterology》2003,98(S9):S86-S86
76.
Hossein Pakdaman Ali Amini Harandi Mehdi Abbasi Mohammad Karimi Mohammad Ali Arami Seyed Ali Mosavi Karim Haddadian Omidvar Rezaei Sohrab Sadeghi Guive Sharifi Koroush Gharagozli Parviz Bahrami Farzad Ashrafi Hosein Delavar Kasmae Amirhossein Ghassemi Mehran Arabahmadi Behdad Behnam 《Neurological sciences》2016,37(11):1773-1778
Drug-resistant epilepsy seems like a different disease compared with easy to control epilepsy, and new strategies are needed to help these patients. Vagus nerve stimulation (VNS) therapy is the most frequently used neurostimulation modality for patients with drug-resistant epilepsy who are not eligible for seizure surgery. In this study, we aimed to evaluate the efficacy and adverse effects of VNS in patients with drug-resistant epilepsy in an open-label, prospective, long-term study in Iran. We selected 48 patients with partial-onset drug-resistant epilepsy. Implantations were performed in the neurosurgery department of Loghman Hospital, Tehran, Iran. Follow-up visits were done on monthly bases for 5 years. Forty-four patients completed the study. Mean age of patients was 24.4 years. Mean years of epilepsy history was 14 years. The mean number of anti-epileptic drugs did not significantly change over five years (p = 0.15). There was no exacerbation of epilepsy; however, one patient discontinued his therapy due to unsatisfactory results. Five patient had more than 50 %, and 26 patients (59 %) had 25–49 % reduction in the frequency of monthly seizures persistently. Overall mean frequency of monthly seizures decreased by 57.8, 59.6, 65, 65.9, and 67 %, in 1st, 2nd, 3rd, 4th, and 5th years of follow-up, respectively. Most common side effects were as follows: hoarseness (25 %) and throat discomfort (10 %). We found VNS as a safe and effective therapy for drug-resistant epilepsy, with an approximate long-term decrease in mean seizure frequency of 57.8–67 %. Thus, VNS is recommended for suitable patients in developing countries. 相似文献
77.
Sohrab Saeb Mi Zhang Christopher J Karr Stephen M Schueller Marya E Corden Konrad P Kording David C Mohr 《Journal of medical Internet research》2015,17(7)
BackgroundDepression is a common, burdensome, often recurring mental health disorder that frequently goes undetected and untreated. Mobile phones are ubiquitous and have an increasingly large complement of sensors that can potentially be useful in monitoring behavioral patterns that might be indicative of depressive symptoms.ObjectiveThe objective of this study was to explore the detection of daily-life behavioral markers using mobile phone global positioning systems (GPS) and usage sensors, and their use in identifying depressive symptom severity.MethodsA total of 40 adult participants were recruited from the general community to carry a mobile phone with a sensor data acquisition app (Purple Robot) for 2 weeks. Of these participants, 28 had sufficient sensor data received to conduct analysis. At the beginning of the 2-week period, participants completed a self-reported depression survey (PHQ-9). Behavioral features were developed and extracted from GPS location and phone usage data.ResultsA number of features from GPS data were related to depressive symptom severity, including circadian movement (regularity in 24-hour rhythm; r=-.63, P=.005), normalized entropy (mobility between favorite locations; r=-.58, P=.012), and location variance (GPS mobility independent of location; r=-.58, P=.012). Phone usage features, usage duration, and usage frequency were also correlated (r=.54, P=.011, and r=.52, P=.015, respectively). Using the normalized entropy feature and a classifier that distinguished participants with depressive symptoms (PHQ-9 score ≥5) from those without (PHQ-9 score <5), we achieved an accuracy of 86.5%. Furthermore, a regression model that used the same feature to estimate the participants’ PHQ-9 scores obtained an average error of 23.5%.ConclusionsFeatures extracted from mobile phone sensor data, including GPS and phone usage, provided behavioral markers that were strongly related to depressive symptom severity. While these findings must be replicated in a larger study among participants with confirmed clinical symptoms, they suggest that phone sensors offer numerous clinical opportunities, including continuous monitoring of at-risk populations with little patient burden and interventions that can provide just-in-time outreach. 相似文献
78.
79.
Krohn K Gehle D Dey SK Nahar N Mosihuzzaman M Sultana N Sohrab MH Stephens PJ Pan JJ Sasse F 《Journal of natural products》2007,70(8):1339-1343
A new complex iridoid, prismatomerin (1), has been isolated from the leaves of Prismatomeris tetrandra, together with the known glucoside gaertneroside (4). The structures of 1 and 4 were determined by spectroscopic analysis, notably 2D NMR techniques. The (1R,5S,8S,9S,10S)-(-) absolute configuration of prismatomerin (1) was determined by comparison of the vibrational circular dichroism (VCD) spectrum calculated using density functional theory and the experimental VCD spectrum of the O-acetyl derivative 3. Prismatomerin (1) showed remarkable antitumor activity and also interfered with mitotic spindle formation. 相似文献
80.
The racemate and enantiomers of 2-chloromandelic acid were characterized by SS-NMR, XRPD, and FTIR. The binary melting point phase diagram was constructed by DSC (differential scanning calorimetry). The solid-state nature of 2-chloromandelic acid was identified to be a racemic compound. The crystal structure of racemic compound was determined to be monoclinic P2(1)/c. 相似文献