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排序方式: 共有627条查询结果,搜索用时 7 毫秒
621.
Davie AP; Francis CM; Caruana L; Sutherland GR; McMurray JJ 《QJM : monthly journal of the Association of Physicians》1997,90(5):335-339
We assessed the value of symptoms, past history, medications and signs in
the evaluation of patients who might have heart failure secondary to left
ventricular systolic dysfunction. An open-access echocardiography service
was set up to help identify patients with left ventricular systolic
dysfunction who might benefit from treatment with an
angiotensin-converting-enzyme inhibitor. History and examination were
recorded for each of these patients. The patients were divided into groups
according to whether left ventricular systolic function was preserved or
not and whether various clinical features were present or not. Of 259
consecutive patients studied, 41 had impairment of left ventricular
systolic function as assessed by echocardiography. Past history of
myocardial infarction and displaced apex beat were the best single
predictors of left ventricular systolic dysfunction as assessed by
echocardiography. The combination of past history of myocardial infarction
and displaced apex had the best positive predictive value of all. Patients
with such clinical features or combinations of clinical features may not
need echocardiography, and where access to this resource is limited, it
could be reserved for patients without such diagnostic features.
相似文献
622.
The neutrophil-specific NB antigen system has been serologically characterized with human alloantisera. Two alleles, NB1 and NB2, have been described; however, there may be important quantitative or qualitative variation in the expression of NB1 and NB2. Human alloantibodies have been used to identify the 58- to 64-kDa glycoprotein (GP) on which NB1 antigen is located, but an NB2 antigen- bearing molecule has not yet been identified. To identify the NB2 molecule, human alloantibody to NB1 was used to isolate the 58- to 64- kDa NB1 GP, and rabbits were immunized with this GP. Two rabbit antisera were produced. Both antisera immunoblotted and immunoprecipitated the 58- to 64-kDa GP on which NB1 is located, but neither identified the molecule on which NB2 is located. The inability of two rabbit polyclonal antibodies specific for the NB1 molecule to react with the NB2-bearing molecule suggests that considerable differences may exist between these two molecules or that NB2 as currently defined is not related to NB1. 相似文献
623.
Autoimmunity as an aetiological factor in vitiligo 总被引:2,自引:0,他引:2
N Rezaei†‡ NG Gavalas‡ AP Weetman‡ EH Kemp‡ 《Journal of the European Academy of Dermatology and Venereology》2007,21(7):865-876
Vitiligo is a common dermatological disorder characterized by the presence on the skin of depigmented macules resulting from the destruction of cutaneous melanocytes. Autoimmunity is an important hypothesis with regard to vitiligo aetiology and the evidence for autoimmune responses being involved in the pathogenesis of this disorder will be discussed in the present review. All immune system compartments, including innate and adaptive immunity have been implicated in vitiligo development. Particularly relevant are autoantibodies and autoreactive T cells in vitiligo patients that have cytotoxic effects upon pigment cells. Furthermore, predisposition to vitiligo appears to be associated with certain alleles of the major histocompatibility complex class II antigens as well as with other autoimmune-susceptibility genes. Moreover, the association of vitiligo with autoimmune disorders, the animal models of the disease, and the positive response to immunosuppressive therapeutic agents emphasize the role of autoimmunity in the development of this disorder. 相似文献
624.
Hydroxyl radicals and the toxicity of oral iron 总被引:2,自引:0,他引:2
625.
Robert Master Michael H. Weisman Thomas G. Armbuster Jack Slivka Donald Resnick Thomas G. Goergen 《Arthritis \u0026amp; Rheumatology》1977,20(8):1500-1506
Seven patients (eight shoulders) with sepsis of the glenohumeral joint were studied clinically and radio-graphically. Despite the advanced age of the patients, the presence of gram-negative organisms, and multiple risk factors in each patient (including serious chronic underlying diseases), needle drainage and parenteral antibiotics were all that were required for successful management, provided early diagnosis with prompt institution of antibiotics and drainage occurred. Contrast arthrography safely guided therapy and revealed rotator cuff tears in four of six shoulders as well as frequent extra-articular extensions of the disease. A nonleukemic patient with Aero-monas hydrophilia sepsis and arthritis is reported who survived with eradication of infection and preservation of joint function. A poor prognosis for shoulder sepsis is not substantiated. 相似文献
626.
627.
Yvonne Nong MS Jessica Maloh ND Nicole Natarelli BA Hemali B. Gunt PhD Esther Tristani PhD Raja K. Sivamani MD MS AP 《Journal of Cosmetic Dermatology》2023,22(8):2166-2173