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21.
Dimytri A. Siqueira MD PHD Matheus Simonato MD Auristela A. Ramos MD PhD Tiago Bignoto MD PhD David Le Bihan MD PhD Rodrigo B. M. Barreto MD PhD Tiago Senra MD PhD Ibraim M. Pinto MD PhD Antonio M. Kambara MD PhD Magaly A. Santos MD PhD Renata Viana MD Amanda G. M. R. Sousa MD PhD Alexandre A. C. Abizaid MD PhD 《Catheterization and cardiovascular interventions》2021,97(1):167-174
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Renato Nicolás Hopp DDS MSc Douglas Cardoso de Siqueira Marcondes Sena‐Filho Jacks Jorge DDS MSc PhD 《Special care in dentistry》2013,33(3):150-153
Hereditary hemorrhagic telangiectasia (HHT) is an inherited mucocutaneous disease characterized by recurrent epistaxis, lesions on skin and oral mucosa, and arteriovenous malformations of the soft tissues. This article describes the treatment of a 64‐year‐old woman with a bleeding nodule, which was diagnosed as an arteriovenous malformation of the gingival mucosa. She was treated using sclerotherapy. Patients with HHT can be treated in the dental office and vascular malformations of these patients can be successfully managed with sclerotherapy, which eliminates the need for invasive surgical procedures and the possibility of postsurgical complications. 相似文献
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Janine Braga de Souza Jacqueline de Souza Lara Maria Lopes de Castro Melissa Fabíola Siqueira Ranylson Marcello Leal Savedra 《Pharmaceutical development and technology》2019,24(3):283-292
This study aimed at evaluating the shake-flask use as a universal method to evaluate drug solubility in a biowaiver context as proposed by FDA, EMA and ANVISA. The solubility of losartan was determined in three buffers using the shake-flask method, intrinsic dissolution (ID) and Quantum Chemistry. Moreover, the evaluation of a losartan dissolution profile from coated tablets was conducted. The losartan low solubility in pH 1.2 and high solubility in pH 6.8 were observed using the shake-flask method. However, the solubility results using ID demonstrated its high solubility in pH 1.2 and 6.8. It was not possible to find conclusive results regarding the solubility of the drug in pH 4.5. The studies conducted by Quantum Chemistry provide molecular and electronic data that helped understand the losartan solvation in different pH values. Our experimental results defined that losartan can be classified as a low-solubility drug. In addition, this work shows that shake-flask cannot be a universal method of solubility studies in biowaiver context. Individual analysis will be necessary. The intrinsic dissolution should be considered as a complementary method. 相似文献
25.
Emilia Modolo Pinto Sheila A. C. Siqueira Priscilla Cukier Maria C. B. V. Fragoso Chin Jia Lin Berenice Bilharinho de Mendonca 《Pituitary》2011,14(4):400-404
Nelson’s syndrome (NS) is characterized by the appearance and/or progression of ACTH-secreting pituitary macroadenomas in
patients who had previously undergone bilateral adrenalectomy for the treatment of Cushing’s disease. Such corticotroph macroadenomas
respond poorly to currently available therapeutic options which include surgery, radiotherapy and chemotherapy. P53 protein
accumulation may be detected by immunohistochemistry in pituitary corticotroph adenomas and it has been suggested that it
might be causally related to tumor development. Wild type P53 protein plays an important role in the cellular response to
ionizing radiation and other DNA damaging agents and is mutated in many human tumors. In this study we report an adult male
patient with NS who underwent both transsphenoidal and transcranial pituitary surgeries, conventional and stereotaxic radiotherapy
and brachytherapy. Despite of the efforts to control tumor mass and growth, this macroadenoma displayed relentless growth
and aggressive behavior. DNA extracted from the first two surgical samples, as well as DNA from peripheral blood leukocytes
disclosed normal p53 sequence. DNA extracted from tumor samples obtained at surgeries performed after pituitary irradiation carried a somatic
heterozygous mutation, consisting of a deletion of four cytosines between nucleotides 12,144–12,149 in exon 4 of the p53 gene. This frameshift mutation creates a stop codon in exon 4 excluding the expression of a functional protein from the defective
allele. These data demonstrate a possible association between the P53 protein loss of function induced by radiotherapy and
the aggressive course of the disease in this patient. 相似文献
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Ribeiro MG Salerno T Mattos-Guaraldi AL Camello TC Langoni H Siqueira AK Paes AC Fernandes MC Lara GH 《Revista do Instituto de Medicina Tropical de S?o Paulo》2008,50(3):177-185
Phenotypic characteristics, antimicrobial susceptibility profile, and clinical-epidemiological features of 28 Nocardia strains isolated from 19 cases of bovine mastitis, eight cutaneous-subcutaneous lesions and one case of pneumonia in dogs were evaluated. Microbiological, biochemical, cytological and scanning electron microscopy methods were used in diagnosis. Nocardia asteroides type IV, Nocardia otitidiscaviarum,Nocardia nova (type III) and Nocardia farcinica (type V) were isolated from bovine milk, bronchial lavage and/or cutaneous-subcutaneous abscesses in dogs. Nocardial bovine mastitis was diagnosed predominantly in clinical cases, in dairy herds with poor environmental hygienic conditions between milking and inappropriate intramammary therapy. Canine nocardiosis was observed commonly in animals co-infected with distemper virus. Sulphamethoxazole-trimethoprim (92.8%), amikacin (92.8%) and ceftiofur (92.8%) were the most effective drugs in 28 isolates. Multiple drug resistance to three or more and five or more antimicrobials was observed in ten (35.7%) and three (10.7%) strains, respectively, predominantly with use of cloxaxillin, cefoperazone and ampicillin. The species (type) classification, clinical-epidemiological characteristics, diagnosis, multiple-drug resistance and public health considerations in Nocardia strains isolated from cattle and dogs in Brazil are discussed, with special reference to report of bovine mastitis by N. otitidiscaviarum by first time in Brazil and the similarity between Nocardia species isolated from human and animal origin. 相似文献
30.
Viral respiratory infection in Curitiba, Southern Brazil 总被引:1,自引:0,他引:1