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11.
Salvador Vilar Correia Lima Humberto Montoro Chagas Caio Cesar Paes Monteiro Rafaela Siqueira Ferraz-Carvalho Amanda Vasconcelos Albuquerque Anderson Arnaldo Silva Mariana Montenegro de Melo Lira Fbio Oliveira Vilar 《Translational andrology and urology》2021,10(2):841
BackgroundPenile prostheses are the third option in the treatment of erectile dysfunction, however, despite their proven effectiveness, the occurrence of infections, advanced age of patients and comorbidities are the main limiting factors for this treatment modality. In the continuous search for biointegrated, clinically durable and minimally invasive treatment options, a possible model of penile prosthesis was sought through the use of intracavernous bacterial cellulose (BC) gel, in an experimental model of orchiectomized rabbits.MethodsThirty adult New Zealand rabbits were equally distributed into three groups: BC; vehicle and control. Each group was then subdivided according to the follow-up time of 3 and 6 months. Bilateral orchiectomy was performed 3 weeks before injection in the BC and vehicle groups. Pachymetry measurements of the penile axis, diameter and length were performed in situ. Histomorphometry analyzes of the corpora cavernosa (CC), thickness of the tunica albuginea, cell density, collagen and elastic fibers post-injection were also performed, in addition to immunohistochemistry for newly formed vessels.ResultsThe implant of BC increased both the length and thickness of the penis three and six months after the last injection, with a consequent increase in the diameter of the CC. On the other hand, the filling effect was not observed in the control and vehicle groups, confirming the degradation of this tissue after orchiectomy and the effectiveness of BC as a filling agent. Histomorphometry analyzes corroborate the mass effect of BC integrated into the tissue, permeated by predominantly lymphomononuclear inflammatory infiltrate, multinucleated giant foreign body cells, fibroblasts, elastic fibers and newly formed vessels, without degradation or loss of volume, even after six months of implantation.ConclusionsBiocompatibility and biointegration to the host tissue make BC a prosperous penile filling material, with local application and minimally invasive. 相似文献
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The roots and stems of ARISTOLOCHIA TRIANGULARIS C HAMISSO, a woody climber growing in Brasil, contain fatty acids as well as (-)-kaur-16-en-18-acid, but no aristolochic acids. The following stigmastane type triterpenes have been isolated: stigmast-4-en-3-on, stigmastan-3,6-dion and stigmast -4-en-3,6-dion as well as kaurane diterpenes: (-)-kaur-16-en, (-), kaur-16-en-18-al, (-)-kauran-16alpha-ol-18-al, (-)-16alpha, 17-epoxykauran, (-)-kaur- 16 - en-18-ol and (-)-kaur-15-en-17-ol. In addition sesquiterpenes have been found: (-)-alpha-ylangen, (-)-alpha-copaen, (E)-beta-elemen, gamma-elemen, (E)-(R)-Nerolidol. The lignanes isolated from A. TRIANGULARIS include cubebin, found so far only in PIPER CUBEBA, and GALBACIN. The new lignans 3,4-dimethoxy-3,4-desmethylendioxycubebin and 3',4'-dimethoxy-3',4'-desmethylendioxycubebin have been identified. For better interpretation of the (1)H-NMR-spectra in relation to the stereochemistry, the 6,6'-dinitro derivates are suitable. 相似文献
15.
IR. B. J. Hartog D. H. Liem 《Pharmacy World & Science》1981,3(1):273-283
Conclusie De verscheidenheid aan conserveermiddelen die in cosmetica worden toegepast, is zeer groot. Het is wenselijk het gebruik van deze verbindingen zo beperkt mogelijk te houden in verband met ongewenste bijwerkingen voor de gebruikers. Een effectieve conservering van produkten, waarin micro-organismen goed kunnen groeien, is echter noodzakelijk. Deskundige microbiologische begeleiding bij de ontwikkeling en fabricage van cosmetische produkten is dan ook essentieel.
Voordracht gehouden tijdens het symposium Conserveermiddelen op 13 november 1980 te Rotterdam.
Dit artikel wordt gelijktijdig geplaatst in De Waren Chemicus. 相似文献
Voordracht gehouden tijdens het symposium Conserveermiddelen op 13 november 1980 te Rotterdam.
Dit artikel wordt gelijktijdig geplaatst in De Waren Chemicus. 相似文献
16.
Adult T cell leukemia-lymphoma (ATL) caused by HTLV-I may be associated with severe immunosupression and several opportunistic infections. Toxoplasmic encephalitis is a common central nervous system opportunistic infection in severely immunosupressed patients, however spinal cord involvement by this parasite is rare. In this paper, we report a case of toxoplasmic myelitis in a patient with ATL. 相似文献
17.
Effect of genetic modification of acute inflammatory responsiveness on tumorigenesis in the mouse 总被引:1,自引:3,他引:1
18.
Caroline Louise Diniz Pereira Joelma Carvalho Santos Raissa Melo Arruda Milena Lima Rodrigues Eduardo Sampaio Siqueira Roberto Souza Lemos Andrea Dória Batista Ana Lúcia Coutinho Domingues Edmundo Pessoa Lopes 《Ultrasound in medicine & biology》2021,47(5):1235-1243
In patients with Mansoni schistosomiasis, it is fundamental to evaluate the disease morbidity, which is reflected by the severity of periportal fibrosis (PPF) and parameters of portal hypertension, as analyzed by ultrasonography (US). This study aimed to evaluate the morbidity of schistosomiasis by hepatic and splenic point shear-wave elastography (pSWE) and relate this to US parameters. The PPF pattern, the diameter of the portal and splenic veins and the size of the spleen were evaluated by US. Then, liver and spleen pSWEs were assessed in 74 patients using the same equipment. As the PPF pattern progressed, the splenic pSWE values significantly increased. Significant correlations between splenic pSWE, the longitudinal and transverse lengths of the spleen and the diameters of the portal and splenic veins were observed. These findings, however, were not observed through hepatic pSWE. In conclusion, the splenic pSWE has the potential for assessing morbidity in schistosomiasis mansoni. 相似文献
19.
Luciana Furlaneto-Maia Kátia Real Rocha Vera Lúcia Dias Siqueira Márcia Cristina Furlaneto 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(2):97-103
Enterococci are increasingly responsible for nosocomial infections
worldwide. This study was undertaken to compare the identification and
susceptibility profile using an automated MicrosScan system, PCR-based assay and
disk diffusion assay of Enterococcus spp. We evaluated 30
clinical isolates of Enterococcus spp. Isolates were identified
by MicrosScan system and PCR-based assay. The detection of antibiotic resistance
genes (vancomycin, gentamicin, tetracycline and erythromycin) was also
determined by PCR. Antimicrobial susceptibilities to vancomycin (30 µg),
gentamicin (120 µg), tetracycline (30 µg) and erythromycin (15 µg) were tested
by the automated system and disk diffusion method, and were interpreted
according to the criteria recommended in CLSI guidelines. Concerning
Enterococcus identification the general agreement between
data obtained by the PCR method and by the automatic system was 90.0% (27/30).
For all isolates of E. faecium and E. faecalis
we observed 100% agreement. Resistance frequencies were higher in E.
faecium than E. faecalis. The resistance rates
obtained were higher for erythromycin (86.7%), vancomycin (80.0%), tetracycline
(43.35) and gentamicin (33.3%). The correlation between disk diffusion and
automation revealed an agreement for the majority of the antibiotics with
category agreement rates of > 80%. The PCR-based assay, the
van(A) gene was detected in 100% of vancomycin resistant
enterococci. This assay is simple to conduct and reliable in the identification
of clinically relevant enterococci. The data obtained reinforced the need for an
improvement of the automated system to identify some enterococci. 相似文献
20.
Vivian Siqueira Santos Gonçalves Eliane Rodrigues de Faria Sylvia do Carmo Castro Franceschini Silvia Eloiza Priore 《Jornal de pediatria》2013,89(6):567-574
Objectivethis study was performed to determine the predictive capacity of four different bioelectrical impedance analysis (BIA) devices in the assessment of adolescents, with and without a protocol.Methodsa cross-sectional study was performed with 215 adolescents aged 10 to 14 years, of both genders, evaluated through anthropometry and body composition by dual energy X-ray absorptiometry (DXA) and by four different BIA devices, with and without a protocol. The following tests were used: Kolmogorov-Smirnov's, chi-squared, Student's t or Mann-Whitney's, Kruskal-Wallis's, Wilcoxon's, and kappa index. The ROC curves were constructed and the sensitivity, specificity, and positive and negative predictive values were calculated.Resultsof the 215 adolescents, 44.2% had excessive body fat. The tetrapolar BIA device equipped with eight tactile electrodes showed more sensitivity and results that were closer to those obtained by DXA (area under the ROC curve [AUC] = 0.964 with protocol and AUC = 0.973 without protocol, p < 0.001), as well as greater agreement (k = 0.67 with protocol and k = 0.63 without protocol, p < 0.001). The evaluation without protocol was similar to that by DXA in most investigated situations (p > 0.05).ConclusionBIA is capable of predicting alterations in adolescents’ body composition. When it is impossible to perform the assessment with a protocol, its results may be useful in population studies. 相似文献